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Inhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl_-2-chloro-n-methyl-ethylammonium chloride

dc.contributor.authorLouw, Ann
dc.contributor.authorAllie, F.
dc.contributor.authorSwart, A. C.
dc.contributor.authorSwart, P.
dc.date.accessioned2012-02-06T08:35:48Z
dc.date.available2012-02-06T08:35:48Z
dc.date.issued2000
dc.identifier.citationLouw, A., Allie, F., Swart, A. C. & Swart, P 2000. Inhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl_-2-chloro-n-methyl-ethylammonium chloride. Endocrine Research, 26(4), 729-736.en_ZA
dc.identifier.issn1532-4206 (online)
dc.identifier.issn0743-5800 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/19572
dc.descriptionThe original publication is available at http://informahealthcare.comen_ZA
dc.description.abstractThe interaction of several biogenic amines and Compound A (2-(4-acetoxyphenyl)-2-chloro- N-methyl-ethylammonium chloride), an analogue of the active substance in a HPLC fraction isolated from the shrub, Salsola tuberculatiformis Botsch., with cytochrome P450c11 was investigated. Noradrenaline, octopamine and Compound A inhibited the type I DOC induced difference spectrum of P450c11 and elicited a type II difference spectrum when added alone. The Ks-values for noradrenaline, octopamine, and Compound A were 0.8 mM, 0.16 mM and 0.36 mM, respectively. Dopamine, adrenaline and synephrine did not interact with, or inhibit, P450c11. Further investigation of Compound A indicated that it is a mixed inhibitor of sheep P450c11 with a stronger competitive (Kic = 106-110 µM) than uncompetitive (Kiu = 667-737 µM) element.en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherInforma Healthcareen_ZA
dc.subjectBiogenic amine interactionen_ZA
dc.subjectCompound Aen_ZA
dc.subjectCytochrome P-450en_ZA
dc.titleInhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl_-2-chloro-n-methyl-ethylammonium chlorideen_ZA
dc.typeArticleen_ZA
dc.description.versionPost-printen_ZA
dc.rights.holderInforma Healthcareen_ZA


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