Now showing items 1-10 of 12
Enabling multiscale modeling in systems medicine
(BioMed Central, 2014-03)
[See article for abstract].
The role of theory and modeling in medical research
(Frontiers Media, 2013-12-19)
No abstract available.
Evolution of computational models in BioModels Database and the Physiome Model Repository
(BioMed Central, 2018-04-12)
ENGLISH SUMMARY : Background: A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and ...
Dissecting long-term glucose metabolism identifies new susceptibility period for metabolic dysfunction in aged mice
(Public Library of Science, 2015)
Metabolic disorders, like diabetes and obesity, are pathogenic outcomes of imbalance in glucose metabolism. Nutrient excess and mitochondrial imbalance are implicated in dysfunctional glucose metabolism with age. We used ...
Anti-inflammatory effects of reactive oxygen species : a multi-valued logical model validated by formal concept analysis
(BioMed Central, 2014-09)
Background: Recent findings suggest that in pancreatic acinar cells stimulated with bile acid, a pro-apoptotic effect of reactive oxygen species (ROS) dominates their effect on necrosis and spreading of inflammation. The ...
Annotation-based feature extraction from sets of SBML models
(BioMed Central, 2015-04-15)
Background: Model repositories such as BioModels Database provide computational models of biological systems for the scientific community. These models contain rich semantic annotations that link model entities to concepts ...
(Frontiers Media, 2014-01-28)
Next generation sequencing technologies are bringing about a renaissance of mining approaches. A comprehensive picture of the genetic landscape of an individual patient will be useful, for example, to identify groups of ...
COMODI : an ontology to characterise differences in versions of computational models in biology
(BioMed Central, 2016-07-11)
Background: Open model repositories provide ready-to-reuse computational models of biological systems. Models within those repositories evolve over time, leading to different model versions. Taken together, the underlying ...
Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice
Reactive oxygen species (ROS) have been implicated in the pathogenesis of acute pancreatitis (AP) for many years but experimental evidence is still limited. Uncoupling protein 2 (UCP2)-deficient mice are an accepted model ...
TRAPLINE : a standardized and automated pipeline for RNA sequencing data analysis, evaluation and annotation
(BioMed Central, 2016)
Background: Technical advances in Next Generation Sequencing (NGS) provide a means to acquire deeper insights into cellular functions. The lack of standardized and automated methodologies poses a challenge for the analysis ...