In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives

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dc.contributor.author Evdokimov N.M.
dc.contributor.author Lamoral-Theys D.
dc.contributor.author Mathieu V.
dc.contributor.author Andolfi A.
dc.contributor.author Frolova L.V.
dc.contributor.author Pelly S.C.
dc.contributor.author Van Otterlo W.A.L.
dc.contributor.author Magedov I.V.
dc.contributor.author Kiss R.
dc.contributor.author Evidente A.
dc.contributor.author Kornienko A.
dc.date.accessioned 2012-01-18T08:06:28Z
dc.date.available 2012-01-18T08:06:28Z
dc.date.issued 2011
dc.identifier.citation Bioorganic and Medicinal Chemistry
dc.identifier.citation 19
dc.identifier.citation 23
dc.identifier.citation http://www.scopus.com/inward/record.url?eid=2-s2.0-80655146928&partnerID=40&md5=387132308634a89e1234ac70dffd5f10
dc.identifier.issn 9680896
dc.identifier.other 10.1016/j.bmc.2011.09.051
dc.identifier.uri http://hdl.handle.net/10019.1/18999
dc.description Please help us populate SUNScholar with the post print version of this article. It can be e-mailed to: scholar@sun.ac.za
dc.subject 1 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 2 yl benzoate
dc.subject 1 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 2 yl pivalate
dc.subject 1 hydroxy 4,5,7,12b tetrahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 2(3a1h) one
dc.subject 1,2 dihydroxy 3a1,4,5,12b tetrahydro 1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(2h) one
dc.subject 1,2,3 trihydroxy 2,3,5,12b tetrahydroxy1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(3a1h) one
dc.subject 1,2,3,4 tetrahydroxy 3,3a,3a1,4,5,12b hexahydro 1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(2h) one
dc.subject 2 (triisopropylsilyloxy) 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 ol
dc.subject 2 (triisopropylsilyloxy)2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl acetate
dc.subject 2 (triisopropylsilyloxy)2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl palmitate
dc.subject 2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl acetate
dc.subject 2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl benzoate
dc.subject 2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl palmitate
dc.subject 2 hydroxy 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 1 yl stearate
dc.subject 2 hydroxy 4h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 7(5h) one
dc.subject 2,3a,4,5,7,12b hexahydro 1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate
dc.subject 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl dibenzoate
dc.subject 3,3a dihydroxy 7 oxo 2,3,3a,3a,4,5,7,12b octahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate
dc.subject 3a hydroxy 7 oxo 2,3,3a,3a1,4,5,7,12b octahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2,3,triyl triacetate
dc.subject 7 oxo 2,3,3a1,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2,3,triyl triacetate
dc.subject 7 oxo 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate
dc.subject 7 oxo 5,7 dihydro 4h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridin 2 yl acetate
dc.subject 7 thioxo 2,3,3a,3a1,4,5,7,12b octahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2,3,3a tetraol
dc.subject 7 thioxo 2,3a1,4,5,7,12b hexahydro1h [1,3]dioxolo[4,5 j]pyrrolo[3,2,1 de]phenanthridine 1,2 diyl diacetate
dc.subject alkene
dc.subject cytostatic agent
dc.subject hydroxyl group
dc.subject long chain fatty acid
dc.subject lycorine
dc.subject paclitaxel
dc.subject unclassified drug
dc.subject unindexed drug
dc.subject antineoplastic activity
dc.subject apoptosis
dc.subject article
dc.subject cancer inhibition
dc.subject controlled study
dc.subject derivatization
dc.subject dihydroxylation
dc.subject drug structure
dc.subject drug synthesis
dc.subject glioblastoma
dc.subject human
dc.subject in vitro study
dc.subject lung non small cell cancer
dc.subject melanoma
dc.subject nonhuman
dc.subject solid tumor
dc.subject structure activity relation
dc.subject tumor cell line
dc.subject Amaryllidaceae
dc.title In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and growth inhibitory properties of lycorine derivatives
dc.type Article


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