SUNScholar
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Faculty of Medicine and Health Sciences
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Department of Pathology
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Medical Virology
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Now showing items 1-17 of 17

The apoptotic potential of different HIV-1 subtype C Tat mutations in cell culture

Isaacs, Shahieda (Stellenbosch : Stellenbosch University, 2013-03)

The efficiency in which HIV-1 can infect, spread and evade the attack of therapeutic agents can be attributed to a high mutation rate and frequent recombination events. These factors have collectively contributed to the ...
Characterisation of new full-length HIV-1 subtype D viruses from South Africa

Loxton, Andre Gareth Janse van Rensburg, E. Engelbrecht, S. (2004-12)

ENGLISH ABSTRACT: The first episode of HIV-1 in South Africa was documented in 1982. Homosexual transmission of the virus was the predominate mode of transmission in an epidemic of mainly HIV-1 subtype Band D infections. ...
Coreceptor expression and T lymphocyte subset distribution in HIV-infected and TB co-infected South African patients on anti-retroviral therapy

Ngandu, Jean Pierre Kabue (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: In 2007, AIDS caused an estimated 2.1 millions deaths worldwide; about 70% in sub-Saharan Africa. HIV preferentially targets activated CD4 T cells, expressing the major HIV receptor CD4, as well as the ...
Development of selective real-time PCR (SPCR) asays for the detection of K103N resistance mutation in minor HIV-1 populations

Seleka, Mpho Maria (Stellenbosch : Stellenbosch University, 2011-12)

ENGLISH ABSTRACT: Background: The conventional sequence analysis is the most common method used for the detection of drug-resistant mutants. Due to its sensitivity limitations, it is unable to detect these mutants when ...
Genetic aspects of HIV-1 risk in an African setting

Petersen, Desiree C. (Stellenbosch : Stellenbosch University, 2006-12)

Host susceptibility to human immunodeficiency virus-1 (HIV-1) infection and disease progression to acquired immunodeficiency syndrome (AIDS) varies widely amongst individuals. This observation led to the identification ...
In-house genotypic antiretroviral resistance test : optimisation and validation for use in research and diagnostics

Claassen, Mathilda (Stellenbosch : University of Stellenbosch, 2011-03)

It is estimated that 32.8 million people are living with Human Immunodeficiency Virus (HIV) globally with the number of people receiving antiretroviral therapy in low- and middle- income counties increasing to more than ...
Investigating the aetiology of respiratory tract infections in children admitted to Tygerberg Children’s Hospital using molecular methods and viral culture

Maree, Leana (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Introduction Acute respiratory tract infections cause significant morbidity and mortality worldwide, and are the main reason for the utilisation of health care services. Identifying the aetiological ...
The investigation of genotypic antiretroviral drug resistance in the context of the South African national antiretroviral roll-out programme

Van Zyl, Gert Uves (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Introduction: Since the South African public sector antiretroviral roll-out programme started in 2004, the success of antiretroviral combination therapy (cART) has been experienced in terms of survival, ...
Investigation of the molecular epidemiology of HIV-1 in Khayelitsha, Cape Town, using serotyping and genotyping techniques

Jacobs, Graeme Brendon (Stellenbosch : University of Stellenbosch, 2005-12)

There are currently an estimated 5.3 million people infected with human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) in South Africa. HIV-1 group M Subtype C is currently responsible for the ...
Molecular characterization of non-subtype C and recombinant HIV-1 viruses from Cape Town, South Africa

Wilkinson, Eduan (Stellenbosch : University of Stellenbosch, 2009-03)

ENGLISH ABSTRACT: HIV-1 was first diagnosed within South Africa in 1982. In the 1980’s homosexual transmission dominated the HIV-1 epidemic within the country. In the late 1980’s the second HIV-1 epidemic was recognized ...
Molecular identification and characterisation of rodent- and shrew-borne Hantaviruses

Ithete, Ndapewa Laudika (Stellenbosch : University of Stellenbosch, 2010-12)

ENGLISH ABSTRACT: Throughout history disease entities have been described which match the description of diseases now known to be caused by hantaviruses; however these viruses were first identified as the aetiologic agent ...
Mutagenesis and functional studies of the HIV-1 vpr gene and Vpr protein obtained from South African virus strains

Romani, Bizhan (Stellenbosch : University of Stellenbosch, 2011-03)

ENGLISH ABSTRACT: Background: Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is an accessory protein that interacts with a number of host cellular and other viral proteins. Vpr exerts several functions ...
Phenotypic and functional characterization of cytotoxic T lymphocytes in HIV-1 infected South African adults

Pillay, Santhoshan Thiagaraj (Stellenbosch : University of Stellenbosch, 2010-12)

ENGLISH ABSTRACT: In just 25 years since the first reported cases in 1981, the number of Human Immunodeficiency virus (HIV) infected people has risen to 65 million, and over 25 million have died of acquired immunodeficiency ...
Phylogenetic analysis of HIV-1 in Mpumalanga

Msimanga, Wela Patrick (Stellenbosch : Stellenbosch University, 2013-03)

The diversity of HIV-1 sequences derived from patients in Bushbuckridge, Mpumalanga, was investigated. The gag p24, pol p10 and p66/p51, pol p31 and env gp41 gene fragments from 51 patients were amplified and sequenced. ...
Profiling the approach to the investigation of viral infections in cases of Sudden Unexpected Death in Infancy (SUDI) in the Western Cape Province

Burger, Marilize Cornelle (Stellenbosch : University of Stellenbosch, 2011-03)

ENGLISH ABSTRACT: Sudden Unexpected Death in Infancy (SUDI) refers to any such sudden demise in a child. If the child dies while asleep within the first year of life, and if no conclusive cause of death can be ascertained ...
The relationship between Cytomegalovirusspecific cellular immune response and CD4+ T cell count in HIV positive individuals in a South African setting

Arendse, Germaine Veronique (Stellenbosch : University of Stellenbosch, 2011-03)

ENGLISH ABSTRACT: Introduction: Reactivation of human cytomegalovirus (HCMV) infection in individuals infected with human immunodeficiency virus (HIV) may lead to life-threatening end-organ diseases (EOD). The EOD becomes ...
Transfection of baboon dendritic cells with plasmid DNA containing HIV-1C genes : effect of transfection methods on antigen processing and presentation to T lymphocytes

Fiff, Fabian (Stellenbosch : University of Stellenbosch, 2005-12)

There is an urgent need for a safe, effective, affordable human immunodeficiency virus type 1 (HIV-1) vaccine that induces both cellular and humoral immunity. A popular strategy for vaccine design is the use of plasmid ...