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  Evaluation and validation of room temperature biospecimens transportation and storage technologies as an alternative cost effective solution to cold chain logistics and storage within biobanking and/or diagnostics 

  Abulfathi, Fatima Adam (Stellenbosch : Stellenbosch University, 2017-03)

  ENGLISH ABSTRACT : Background: Cold chain management (CCM) is an important aspect of biobanking operation. However challenges such as constant power failure, limited access to dry ice transport and storage of human samples ...
  
  
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  Optimisation of a whole blood flow cytometry assay to aid in the diagnosis of tuberculosis by detecting intracellular cytokines released by CD4+ T-cells 

  Snyders, Candice Irene (Stellenbosch : Stellenbosch University, 2016-03)

  ENGLISH ABSTRACT : Background: South Africa (SA) sees 8 million new Tuberculosis (TB) cases each year and has a significant problem with Human Immunodeficiency Virus (HIV) and TB co-infection. Latent TB infection (LTBI) ...
  
  
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  HIV/AIDS-related non-Hodgkin’s lymphomas and confounders : preliminary report of the Sub-Saharan Africa Lymphoma Consortium (SSALC) 

  Ayers, Leona W.; Abayomi, E. Akin; Adebamowo, Clement; Chumba, David K.; Iliyasu, Yawale; Naresh, Kikkeri N.; NDung’u, Joseph R; Perner, Yvonne; Stevens, Wendy; Tumwine, Lynnette K. (BioMed Central, 2012-04)

  SSALC was established to characterize HIV/AIDS-related lymphoma and the indigenous background of malignant lymphomas (ML) in sub-Saharan Africa. Because WHO classified lymphoma subgroups can vary in prevalence African, ...
  
  
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  Biomarkers of HIV-associated cancer 

  Flepisi, Brian Thabile; Bouic, Patrick; Sissolak, Gerhard; Rosenkranz, Bernd (Libertas Academica, 2014)

  Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular ...
  
  
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  Recommendations for the management of sickle cell disease in South Africa 

  Alli, N. A.; Patel, M.; Alli, H. D.; Bassa, F.; Coetzee, M. J.; Davidson, A.; Essop, M. R.; Lakha, A.; Louw, V. J.; Novitzky, N.; Philip, V.; Poole, J. E.; Wainwright, R. (Health & Medical Publishing Group, 2014-11)

  The spectrum of sickle cell disease (SCD) encompasses a heterogeneous group of disorders that include: (i) homozygous SCD (HbSS), also referred to as sickle cell anaemia; (ii) heterozygous SCD (HbAS), also referred to as ...
  
  
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  The HIV/AIDS epidemic in South Africa : convergence with tuberculosis, socioecological vulnerability, and climate change patterns 

  Abayomi, A.; Cowan, M. N. (Health & Medical Publishing Group, 2014-08)

  Recent assessment reports suggest that climate change patterns are threatening social and ecological vulnerability and resilience, with the strong potential of negatively affecting human health. Persons living with HIV/AIDS ...
  
  
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  Investigating platelet function and immune activation in HIV-infection 

  Nkambule, Bongani Brian (Stellenbosch : Stellenbosch University, 2015-04)

  ENGLISH ABSTRACT: Introduction In the era of antiretroviral therapy (ART), people living with Human Immunodeficiency Virus (HIV) now have prolonged life spans. An emerging trend of non- acquired immune deficiency syndrome ...
  
  
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  A perpetual source of DNA or something really different : ethical issues in the creation of cell lines for African genomics research 

  De Vries, Jantina; Abayomi, Akin; Brandful, James; Littler, Katherine; Madden, Ebony; Marshall, Patricia; Ouwe Missi Oukem-Boyer, Odile; Seeley, Janet (BioMed Central, 2014-08)

  Background: The rise of genomic studies in Africa - not least due to projects funded under H3Africa - is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these ...
  
  
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  Modulation of LPS-induced CD4+ T-cell activation and apoptosis by antioxidants in untreated asymptomatic HIV infected participants : an in vitro study 

  Wanjiku, Samuel Mburu; Marnewick, J. L.; Abayomi, A.; Ipp, H. (Hindawi Publishing Corporation, 2013-11)

  Persistent immune activation characterises HIV infection and is associated with depletion of CD4+ T-cells and increased risk of disease progression. Early loss of gutmucosal integrity results in the translocation of microbial ...
  
  
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  Impact of inflammation-induced oxidative stress on the integrity of immuno-haematopoietic cells and potential ameliorating interventions in an in vitro HIV model 

  Wanjiku, Samuel Mburu (Stellenbosch : Stellenbosch University, 2013-12)

  ENGLISH ABSTRACT: Chronic inflammation and immune activation are hallmarks of HIV infection, resulting in chronic oxidative stress with over-utilization of antioxidant defences, which may contribute to the loss of immune ...
  
  
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  Guideline for the treatment of myelodysplastic syndromes (MDS) in South Africa 

  Louw, V. J.; Bassa, F.; Chan, S. W.; Dreosti, L.; Du Toit, M.; Ferreira, M.; Gartrell, K.; Gunther, K.; Jogessar, V.; Littleton, N.; Mahlangu, J.; McDonald, A.; Patel, M.; Pool, R.; Ruff, P.; Schmidt, A.; Sissolak, G.; Swart, A.; Verburgh, E.; Webb, M. J. (Health and Medical Publishing Group (HMPG), 2011-12)

  Introduction. Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal haematopoietic disorders characterised by chronic and progressive cytopenias resulting from ineffective haematopoiesis. Treatment ...
  
  
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  Myelodysplastic syndromes -- Diagnosis 

  Jacobs, Peter; Wood, Lucille (Health and Medical Publishing Group (HMPG), 2012-12)

  This is the second in our series of clinical articles that discuss everyday presentations. Each emphasises practical aspects of team-based care that are relevant for general practitioners, specialists and paramedical ...
  
  
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  Haemochromatosis : phenotype to genotype or man to molecules 

  Jacobs, P.; Wood, L. (Health and Medical Publishing Group (HMPG), 2013-06)

  This is the third in our vignettes that are centred on everyday clinical presentations. Each emphasises practical aspects of team-based care that are applicable to general practitioners, specialists and paramedical ...
  
  
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  Aplasia versus pancytopenia, including the pure red cell variant 

  Jacobs, Peter; Wood, Lucille (Health and Medical Publishing Group (HMPG), 2012-09)

  This is the first in our third series of clinical vignettes that are centred on everyday presentations. Each emphasises practical aspects of team-based care, having relevance for general practitioners, specialists and ...
  
  
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  Association of deworming with reduced eosinophilia : implications for HIV/AIDS and co-endemic diseases 

  Fincham, J. E.; Markus, M. B.; Adams, V. J.; Lombard, C. J.; Bentwich, Z.; Mansvelt, E. P. G.; Dhansay, M. A.; Schoeman, S. E. (Academy of Science of South Africa, 2003-04)

  Eosinophil counts in venous blood were monitored during a randomized controlled deworming trial (n = 155 children) that lasted for a year, and in a whole-school deworming programme (range 174-256 children) of 2 years' ...
  
  
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  Effects of puff adder venom on coagulation, fibrinolysis and platelet aggregation in the baboon 

  Brink, S.; Steytler, J. G. (Health and Medical Publishing Group (HMPG), 1974)

  The in vitro and in vivo hematological effects of puff adder (Bitis arietans) venom in the baboon (Papio ursinus) with regard to its effect on coagulation, fibrinolysis and platelet aggregation were studied. There is a ...
  
  
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  Oorerflike faktor V gebrek (Parahemofilie) : 'n gevalbespreking 

  Brink S. (HMPG, 1974)

  A white boy and his family were investigated for a haemorrhagic diathesis. Both he and his sister, a primipara between 26 and 28 wk pregnant, in May 1973 had a total lack of factor V, demonstrated an abnormal partial ...
  
  
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  Mielopoiese : 'n kinetiese benadering 

  Brink, S.; Steytler, J. G. (Health and Medical Publishing Group (HMPG), 1975)

  The mechanisms of hemopoietic cellular proliferation are more clearly understood when the granulocytic, monocytic and macrophagic elements of the bone marrow are studied by means of in vitro cultures. Better physiological ...
  
  
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  Chronic myelomonocytic leukaemia: a case report 

  Getaz E.P.; Staples W.G. (HMPG, 1977)

  [No abstract available]
  
  
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  Lympho epithelioid cellular lymphoma (Lennert's lymphoma). A case report 

  Staples, W. G.; Getaz, E. P. (HMPG, 1977-04)

  A woman of 69 with Lennert's lymphoma (malignant lymphoma with a high content of epithelioid histiocytes) is described. The case is unique in that hepatosplenomegaly was the presenting feature (for which splenectomy was ...
  
  
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  Laboratoriumstandaardisasie en kwaliteitskontrole in antistolterapie 

  Brink S.; Cloete H.; Roberts R.; Holm W. (HMPG, 1976-02)

  [No abstract available]
  
  
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  Familial Waldenstrom's macroglobulinaemia: a case report 

  Getaz, E. P.; Staples, W. G. (HMPG, 1977-06)

  A patient with Waldenstrom's macroglobulinemia, whose father died of the same condition, is presented. The literature on familial occurrence of paraproteinaemia is briefly reviewed.
  
  
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  Idiopathic thrombocytopenic purpura and hyperthyroidism : A case report 

  Getaz, E. P.; Staples, W. G. (HMPG, 1977-08)

  A case of immune thrombocytopenic purpura (ITP) and hyperthyroidism is presented. The treatment of refractory ITP with immunosuppressive agents is briefly considered. In 1931 a patient with coexistent purpura and ...
  
  
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  Haemophilia 

  Getaz , E. P.; Staples, W. G.; Lurie, A. (HMPG, 1977-10)

  The clinical and haematological features of haemophilia are reviewed and the historical aspects, pathogenesis and genetics are discussed. The problems associated with management, such as factor replacement, home ...
  
  
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  Age and race distribution of patients who undergo haematological investigations at Tygerberg Hospital (Afrikaans) 

  Brink S.; Van Schalkwyk D.J.; Steytler J.G. (HMPG, 1977-11)

  The race, age and sex of patients referred for peripheral blood investigations at the Tygerberg Hospital were analysed statistically. An IBM 370/158 computer was used. Two groups were compared. The first was a 'low Hb ...
  
  
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  The present status of cytochemistry in the diagnosis of haematological malignancy 

  Staples W.G.; Getaz E.P. (HMPG, 1977-06)

  Newer concepts in the application of cytochemistry to the diagnosis of haematological malignancies are discussed. The underlying physiological principles and location of the various enzymes are indicated. Older stains, ...
  
  
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  Bone marrow involvement in malignant lymphoma without peripheral lymphadenopathy 

  Staples, W. G.; Getaz, E. P. (HMPG, 1977-07)

  Twelve cases of non-Hodgkin's lymphoma and a single case of Hodgkin's disease were first diagnosed on bone marrow biopsy. None of the patients had superficially enlarged lymph nodes, and in 3 patients the histological ...
  
  
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  'n Epidemiologiese studie van perifere bloedondersoeke 

  Brink S.; Van Schalkwyk, D. J. (HMPG, 1979-08)

  A statistical random sample of 600 patients from the population referred to Tygerberg Hospital for peripheral blood investigations was analysed statistically with an IBM 370/158 computer. Suitable transformations ...
  
  
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  Serum ferritin and mean corpuscular volume as predictors of bone marrow iron stores 

  Brink S.; Van Schalkwyk D.J. (HMPG, 1982)

  The prognostic value of serum ferritin (SF) as a predictor of bone marrow iron stores (BMS) was evaluated in an attempt to use SF and other readily available clinical and laboratory parameters in the more accurate prediction ...
  
  
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  Hemangiosarkoom van die bors : 'n gevallestudie en oorsig van die literatuur 

  Van Zyl, J. A.; Van Der Walt, J. J.; Van Zyl, J. J. W. (Health and Medical Publishing Group (HMPG), 1975)

  In this case of angiosarcoma of the breast in a 55 yr old woman, the time from treatment to death was 41 mth, compared with 25 mth in collected cases from the literature. The possible value of adjuvant chemotherapy is ...
  
  

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