Haematological Pathology
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B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(Medpharm Publications, 2018)Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Castleman’s disease in the HIV-endemic setting
(Dove Medical Press, 2018)Introduction: Castleman’s disease (CD), first described by Benjamin Castleman in 1954, is a giant or angiofollicular lymph node hyperplasia, described as a rare monotypic polyclonal B-cell lymphoproliferative disorder with ... -
The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection
(Health & Medical Publishing Group, 2014)Background. A feature of HIV/AIDS is chronic immune activation, which results in a number of complications including inflammation-related disorders and blood cytopaenias. Immune activation status is not routinely tested ... -
Investigating the use of standardized EuroFlow flow cytometry panels for the characterisation and diagnosis of Chronic lymphocytic leukaemia in the Tygerberg Academic Hospital, South Africa.
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH ABSTRACT : Background: Flow cytometry (FC) immunophenotyping is crucial in the diagnosis and classification standardisation of haematological malignancies. FC techniques require standardisation to produce reliable ... -
African civil society initiatives to drive a biobanking, biosecurity and infrastructure development agenda in the wake of the West African Ebola outbreak
(African Field Epidemiology Network, 2016)This paper describes the formation of a civil society consortium, spurred to action by frustration over the Ebola crises, to facilitate the development of infrastructure and frameworks including policy development to support ... -
Evaluation and validation of room temperature biospecimens transportation and storage technologies as an alternative cost effective solution to cold chain logistics and storage within biobanking and/or diagnostics
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT : Background: Cold chain management (CCM) is an important aspect of biobanking operation. However challenges such as constant power failure, limited access to dry ice transport and storage of human samples ... -
Optimisation of a whole blood flow cytometry assay to aid in the diagnosis of tuberculosis by detecting intracellular cytokines released by CD4+ T-cells
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT : Background: South Africa (SA) sees 8 million new Tuberculosis (TB) cases each year and has a significant problem with Human Immunodeficiency Virus (HIV) and TB co-infection. Latent TB infection (LTBI) ... -
Immune activation is associated with decreased thymic function in asymptomatic, untreated HIV infected individuals
(AOSIS Publishing, 2016-07-28)Background: Reduced thymic function causes poor immunological reconstitution in human immunodeficiency virus (HIV)-positive patients on combined antiretroviral therapy (cART). The association between immune activation ... -
HIV/AIDS-related non-Hodgkin’s lymphomas and confounders : preliminary report of the Sub-Saharan Africa Lymphoma Consortium (SSALC)
(BioMed Central, 2012-04)SSALC was established to characterize HIV/AIDS-related lymphoma and the indigenous background of malignant lymphomas (ML) in sub-Saharan Africa. Because WHO classified lymphoma subgroups can vary in prevalence African, ... -
Biomarkers of HIV-associated cancer
(Libertas Academica, 2014)Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular ... -
Recommendations for the management of sickle cell disease in South Africa
(Health & Medical Publishing Group, 2014-11)The spectrum of sickle cell disease (SCD) encompasses a heterogeneous group of disorders that include: (i) homozygous SCD (HbSS), also referred to as sickle cell anaemia; (ii) heterozygous SCD (HbAS), also referred to as ... -
The HIV/AIDS epidemic in South Africa : convergence with tuberculosis, socioecological vulnerability, and climate change patterns
(Health & Medical Publishing Group, 2014-08)Recent assessment reports suggest that climate change patterns are threatening social and ecological vulnerability and resilience, with the strong potential of negatively affecting human health. Persons living with HIV/AIDS ... -
Investigating platelet function and immune activation in HIV-infection
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Introduction In the era of antiretroviral therapy (ART), people living with Human Immunodeficiency Virus (HIV) now have prolonged life spans. An emerging trend of non- acquired immune deficiency syndrome ... -
A perpetual source of DNA or something really different : ethical issues in the creation of cell lines for African genomics research
(BioMed Central, 2014-08)Background: The rise of genomic studies in Africa - not least due to projects funded under H3Africa - is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these ... -
Modulation of LPS-induced CD4+ T-cell activation and apoptosis by antioxidants in untreated asymptomatic HIV infected participants : an in vitro study
(Hindawi Publishing Corporation, 2013-11)Persistent immune activation characterises HIV infection and is associated with depletion of CD4+ T-cells and increased risk of disease progression. Early loss of gutmucosal integrity results in the translocation of microbial ... -
Impact of inflammation-induced oxidative stress on the integrity of immuno-haematopoietic cells and potential ameliorating interventions in an in vitro HIV model
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Chronic inflammation and immune activation are hallmarks of HIV infection, resulting in chronic oxidative stress with over-utilization of antioxidant defences, which may contribute to the loss of immune ... -
Guideline for the treatment of myelodysplastic syndromes (MDS) in South Africa
(Health and Medical Publishing Group (HMPG), 2011-12)Introduction. Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal haematopoietic disorders characterised by chronic and progressive cytopenias resulting from ineffective haematopoiesis. Treatment ... -
Myelodysplastic syndromes -- Diagnosis
(Health and Medical Publishing Group (HMPG), 2012-12)This is the second in our series of clinical articles that discuss everyday presentations. Each emphasises practical aspects of team-based care that are relevant for general practitioners, specialists and paramedical ... -
Haemochromatosis : phenotype to genotype or man to molecules
(Health and Medical Publishing Group (HMPG), 2013-06)This is the third in our vignettes that are centred on everyday clinical presentations. Each emphasises practical aspects of team-based care that are applicable to general practitioners, specialists and paramedical ... -
Aplasia versus pancytopenia, including the pure red cell variant
(Health and Medical Publishing Group (HMPG), 2012-09)This is the first in our third series of clinical vignettes that are centred on everyday presentations. Each emphasises practical aspects of team-based care, having relevance for general practitioners, specialists and ...
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