Markers of susceptibility to acute rheumatic fever: The B-cell antigen D8/17 is not robust as a marker in South Africa

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dc.contributor.author Walker K.G.
dc.contributor.author Cooper M.
dc.contributor.author McCabe K.
dc.contributor.author Hughes J.
dc.contributor.author Mathiassen W.
dc.contributor.author Lawrenson J.
dc.contributor.author Wilmshurst J.M.
dc.date.accessioned 2011-10-13T16:59:02Z
dc.date.available 2011-10-13T16:59:02Z
dc.date.issued 2011
dc.identifier.citation Cardiology in the Young
dc.identifier.citation 21 (3) 328-333
dc.identifier.citation http://www.scopus.com/inward/record.url?eid=2-s2.0-79956054521&partnerID=40&md5=143856543ba10b747f3f040b3f43aaef
dc.identifier.issn 10479511
dc.identifier.other 10.1017/S1047951111000035
dc.identifier.uri http://hdl.handle.net/10019.1/16956
dc.description.abstract Background Acute rheumatic fever and its chronic sequelae, rheumatic cardiac disease, and neuropsychiatric movement disorders, remain major public health problems in South Africa. Early identification and treatment of streptococcal pharyngitis in susceptible individuals would prevent rheumatic cardiac disease. The B-cell antigen D8/17 is a marker of susceptibility to rheumatic fever in some populations.Methods and results We assessed the significance of the D8/17 marker in a group of South Africans. Blood was collected from 107 individuals; 40 patients had previous confirmed rheumatic fever, 20 were first-degree relatives, and 47 were controls. The expression of D8/17 in each sample was analysed by flow cytometry. The mean proportion of B-cells that were D8/17 positive was 0.5% in the index cases, 0.47% in their relatives, and 0.27% in the controls. There was a significant difference between the index cases and the controls, p = 0.03, but the mean percentage positive in each group was very low.Conclusions Patients with a history of rheumatic fever had statistically increased expression of the D8/17 marker. However, the actual percentages in this observational study were markedly lower than in other populations, ranging from 0.14%-1.53% compared to 11.6%-39.3%. The D8/17 marker would be an impractical screening tool in the South African population. Copyright © Cambridge University Press 2011.
dc.subject genetics
dc.subject Prevention
dc.subject rheumatic cardiac disease
dc.subject B lymphocyte antigen
dc.subject D8 17 antigen
dc.subject unclassified drug
dc.subject antigen expression
dc.subject article
dc.subject B lymphocyte
dc.subject controlled study
dc.subject disease marker
dc.subject disease predisposition
dc.subject female
dc.subject flow cytometry
dc.subject geographic distribution
dc.subject human
dc.subject male
dc.subject medical history
dc.subject observational study
dc.subject race difference
dc.subject rheumatic fever
dc.subject screening test
dc.subject South Africa
dc.title Markers of susceptibility to acute rheumatic fever: The B-cell antigen D8/17 is not robust as a marker in South Africa
dc.type Article
dc.description.version Article


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