Anatomical Pathology
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Hyperplastic polyp or sessile serrated lesion? the contribution of serial sections to reclassification
(BMC (part of Springer Nature), 2020)Background: The histological discrimination of hyperplastic polyps from sessile serrated lesions can be difficult. Sessile serrated lesions and hyperplastic polyps are types of serrated polyps which confer different ... -
The investigation of bronchoalveolar lavage fluid in paediatric chronic wheezers
(Stellenbosch : Stellenbosch University., 2020-03)ENGLISH ABSTRACT: Background: Paediatric broncho-alveolar lavage (BAL) is a minimally invasive procedure, performed during flexible bronchoscopy using isotonic saline to obtain a sample of bronchial and alveolar fluid from ... -
HPV strain prevalence and HPV-related biomarker expression in vulvar carcinoma at Tygerberg academic hospital.
(Stellenbosch : Stellenbosch University, 2019-12)ENGLISH ABSTRACT: The incidence of vulvar carcinoma in younger women has increased, possibly due to augmented human papillomavirus (HPV) infection. Variable geographic prevalence of HPV that are associated with vulvar ... -
Incidence of Hodgkin lymphoma in HIV-positive and HIV-negative patients at a tertiary hospital in South Africa (2005 - 2016) and comparison with other African countries
(Health & Medical Publishing Group, 2018-06-26)Background. Hodgkin lymphoma (HL) is the most common non-AIDS-defining cancer in HIV-positive patients. Studies on South African (SA) populations have described the prevalence as 7 - 17% of all lymphomas, 8 - 27% of head ... -
Chemotherapy naive breast cancer: a correlation study between BD Cytorich™ Red cell blocks and formalin- fixed paraffinembedded tissue blocks
(Stellenbosch : Stellenbosch University, 2019-04)Background: The ever increasing burden of breast cancer, the most common cancer among women, demands a diagnostic test that is rapid, reliable, informative and cost-effective; particularly in countries with limited ... -
Fatal tumour pulmonary embolism
(Wiley Open Access, 2017)A 30-year-old female with no significant past medical history was referred to our facility with sudden onset of shortness of breath. She had a low clinical probability for pulmonary thromboembolism and a computed ... -
Evaluating the role of long-term urine bio-banking on the stability of urine bio-markers in the diagnosis of pre-eclampsia
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: The aim of the pre-eclampsia (PE) and eclampsia monitoring, prevention and treatment consortium is to develop a rapid diagnostic test for PE in pregnant women because early identification of PE would ... -
Colonic perineurioma (benign fibroblastic polyp) : case report and review of the literature
(BioMed Central, 2018)Background: Colorectal perineuriomas are uncommon benign mucosal-based proliferations of mesenchymal cells that express perineurial markers, often associated with colonic crypts displaying a serrated/hyperplastic ... -
Exome sequencing in a family with luminal-type breast cancer underpinned by variation in the methylation pathway
(MDPI, 2017-02-22)ENGLISH ABSTRACT: Panel-based next generation sequencing (NGS) is currently preferred over whole exome sequencing (WES) for diagnosis of familial breast cancer, due to interpretation challenges caused by variants of uncertain ... -
A biobank to support HIV malignancy research for sub-Saharan Africa
(Health & Medical Publishing Group, 2016)Sub-Saharan Africa has one of the highest incidences of infection with HIV globally, but more people in this region are living longer owing to increased access to antiretroviral therapy. However, along with increased care ... -
Histological and immunohistochemical evaluation of sentinel lymph nodes in breast cancer at a tertiary hospital in the Western Cape, South Africa
(Health & Medical Publishing Group, 2016-04-19)Background. Breast carcinoma remains the most prevalent cancer among women, with over 300 000 deaths annually worldwide. Axillary lymph node status is essential for the clinical staging of breast carcinoma and remains the ... -
Non-allopathic adjuvant management of osteoarthritis by alkalinisation of the diet
(AOSIS Publishing, 2015)Background: Osteoarthritis (OA) is a chronic condition. Nonsteroidal anti-inflammatory drugs recommended for treatment have serious adverse effects. A compelling body of anecdotal evidence alerted the authors to the ... -
The role of MKP-1 in the anti-proliferative effects of glucocorticoids in primary rat pre-osteoblasts
(Public Library of Science, 2015)Glucocorticoid (GC)-induced osteoporosis has been attributed to a GC-induced suppression of pre-osteoblast proliferation. Our previous work identified a critical role for mitogen-activated protein kinase (MAPK) phosphatase-1 ... -
Investigation and management of primary immunodeficiency in South African children
(Health and Medical Publishing Group, 2014)ENGLISH ABSTRACT: The primary immunodeficiency diseases (PIDs) are inherited, non-communicable diseases that cause immunological dysfunction. PIDs are seldom reported in South Africa (SA). Based on a mid-2013 population ... -
Development and application of a pathology supported pharmacogenetic test for improved clinical management of South African patients with breast cancer and associated co-morbidities
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Three major challenges in the field of breast cancer have been identified as research priorities for this study. The first is the need to combine genetic testing of high-risk patients with familial breast ... -
Development of a novel pre-screen algorithm for cardio-metabolic risk management using a genomics database resource
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: The timely assessment and treatment of dyslipidaemia is an important component of cardiovascular risk screening and intervention. The apolipoprotein E (APOE) ε-2/ε-3/ε-4 polymorphism associated with ... -
Analysis of the clinical utility of gene expression profiling in relation to conventional prognostic markers in South African patients with breast carcinoma
(Stellenbosch : Stellenbosch University, 2014-12)ENGLISH ABSTRACT: Breast cancer is a heterogeneous disease characterised by marked inter-individual variability in presentation, prognosis and clinical outcome. The recognition that morphological assessment has limited ... -
MammaPrint Pre-screen Algorithm (MPA) reduces chemotherapy in patients with early-stage breast cancer
(Health & Medical Publishing Group, 2013-07-03)Background. Clinical and pathological parameters may overestimate the need for chemotherapy in patients with early-stage breast cancer. More accurate determination of the risk of distant recurrence is now possible with use ... -
An evaluation of the diagnostic adequacy and immunocytochemistry of manual liquid-based smears in breast aspirates
(Medpharm Publications, 2013)The aim of this study was to determine if the Syner-Med®/Cell-Solutions® liquid-based cytology (LBC) technique would provide adequate diagnostic material when applied to breast fine-needle aspiration biopsy (FNAB) specimens ... -
Automated sputum screening using the BD FocalPointTM Slide Profiler : correlation with transbronchial and transthoracic needle aspirates in a high risk population
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Background: Sputum is a non-invasive, economic investigation whereby bronchogenic carcinoma can be identified. Manual cytological screening is labour intensive, time-consuming and requires a continuous ...
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