As known disease-associated variants identified through
large cohort-based studies often explain only a small percentage
of genetic risk in multifactorial disorders such as
multiple sclerosis (MS), alternative methods ...
Kotze, Maritha J.Van Rensburg, Susan J.(SpringerLink, 2012-04)
Chronic, multi-factorial conditions caused by a
complex interaction between genetic and environmental risk
factors frequently share common disease mechanisms, as
evidenced by an overlap between genetic risk factors ...
Petersen, Desiree C.Libiger, OndrejTindall, Elizabeth A.Hardie, Rae-AnneHannick, Linda I.Glashoff, Richard H.Mukerji, MitaliIndian Genome Variation ConsortiumFernandez, PedroHaacke, WilfridSchork, Nicholas J.Hayes, Vanessa M.(PLOS, 2013-03)
Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly
proportional to geographic distance. The most divergent contemporary human populations include the ...
ENGLISH ABSTRACT: Infection is a major cause of morbidity and mortality in infants within the first few months of life. Susceptibility to infectious disease in this vulnerable population is more prevalent in resource-limited ...
Van Der Merwe, NicoleBouwens, Christianne S. H.Pienaar, RikaVan Der Merwe, LizeYako, Yandiswa Y.Geiger, Dieter H.Kotze, Maritha J.(Springer Verlag, 2012-05)
Approximately 25 % of clinically important drugs and numerous environmental carcinogens are metabolised by CYP2D6. Variation in the CYP2D6 gene and concomitant use of tamoxifen (TAM) with certain antidepressants may increase ...
Bates, William D.(Stellenbosch : Stellenbosch University, 2011-12)
ENGLISH ABSTRACT: Background and Objective: The most common cause of severe
proteinuria/nephrotic syndrome (NS) in children worldwide is minimal change disease
(MCD). This is also the pattern observed in white and Indian ...
ENGLISH ABSTRACT: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease in Western countries and is considered the hepatic manifestation of the Metabolic Syndrome (MetS). Its heterogeneous ...
Wright, C. A.Bamford, C.Prince, Y.Vermaak, A.Hoek, K. G. P.Marais, B. J.Warren, R. M.(BMJ Publishing Group, 2010-01)
Fine needle aspiration biopsy (FNAB) offers a simple outpatient technique for specimen collection in child tuberculosis suspects with peripheral lymphadenopathy. To perform FNAB with mycobacterial culture on an outpatient ...
Van Der Walt J. J.Marcus P. B.De Wet J. J.Burger A. J. J.(HMPG, 1973-8)
The first case of malacoplakia known to have affected the female genital tract is presented. This lesion involved the upper vagina and presented clinically as an infiltrating carcinoma. No evidence of malacoplakia of the ...
A metastatic tumour growing in the heart more than 2 years after total removal of the primary hepatic growth is a rare event. Jaundice as a result of bile production by the metastasis is most unusual. The primary tumour ...
Villet, W. T.Du Toit, D .F.Conroy, C.(Health and medical Publishing Group (HMPG), 1979-01)
Authors report the management of a case of malignant trophoblastic disease which presented initially as a haematemesis and melaena from a gastric metastasis. The patient had had a tubal sterilization 4 years previously. ...
Three patients with gangrene of the penis after Xhosa
ritual tribal circumcision are reported. A review of
complications which may follow circumcision is given.
Van Der Merwe P.L.Gie R.P.Hunter J.Mouton, S. C. E.Schwar, G. T.Gleeson, C. M.(HMPG, 1980-12)
Two cases of Kawasaki disease, both with cardiac involvement.
are reported in South African children and
the diagnostic problems are discussed. In patient 1 an
ECG showed the development of an .inferior myocardial
infarction, ...
Przybojewski J. Z.Van Der Walt J. J.Van Eeden P. J.Tiedt F. A. C.(Health and Medical Publishing Group (HMPG), 1984)
Two young White brothers had dilated (congestive) cardiomyopathy. The elder came to autopsy after a chronic course of congestive cardiac failure; the younger underwent repeated cardiac catheterization and transvenous right ...
Van der Walt, J. J.(Health and Medical Publishing Group (HMPG), 1975)
Hearts from 32 patients with idiopathic cardiomyopathy were examined postmortem. A comparative morphological study of the human hearts and of hearts from cardiomyopathic hamsters, rabbits and baboons indicates that severe ...
Wright, Colleen Anne(Stellenbosch : University of Stellenbosch, 2009-12)
ENGLISH ABSTRACT: Expediting a diagnosis of tuberculosis in children, particularly those who are immunocompromised due to HIV/AIDS, is essential, as they are vulnerable to develop severe forms of disease due to their ...
Bezuidenhout, Juanita(University of Stellenbosch. Faculty of Health Sciences. Dept. of Biomedical Sciences., 2005-12)
The formation of granulomas at the site of antigen presentation in both tuberculosis and
sarcoidosis is an essential component of host immunity for controlling inflammation.
Granuloma formation is a complex process that ...
Van Rensburg, C. J.(Stellenbosch : University of Stellenbosch, 2006-03)
Patients with chronic gastro-oesophageal reflux disease are predisposed to Barrett’s metaplasia and oesophageal adenocarcinoma. The availability of molecular markers that can objectively identify patients with Barrett’s ...