Browsing Department of Pathology by Title

C-reactive protein. Properties and biological action with particular reference to systemic lupus erythematosus

Macfarlane C. M. (Health and Medical Publishing Group (HMPG), 1985)

A dramatic increase in serum C-reactive protein levels occurs in response to specific bacterial infection or tissue damage. This protein forms part of the acute-phase response, and it appears to function as an independent ...

Candida species : species distribution and antifungal susceptibility patterns

Arendse, Tracy Orth, Heidi (Health and Medical Publishing Group (HMPG), 2008)

[No abstract available]

The characterisation and expression of HIV-1 subtype C gag

Sampson, Candice Corene (Stellenbosch : Stellenbosch University, 2002)

ENGLISH ABSTRACT: The gag gene of HIV-1 encodes for one of the major structural proteins, which contains several conserved cytotoxic T cell (CTL) epitopes. Gag specific CTL responses are important in controlling viral ...

Characterisation of new full-length HIV-1 subtype D viruses from South Africa

Loxton, Andre Gareth Janse van Rensburg, E. Engelbrecht, S. (2004-12)

ENGLISH ABSTRACT: The first episode of HIV-1 in South Africa was documented in 1982. Homosexual transmission of the virus was the predominate mode of transmission in an epidemic of mainly HIV-1 subtype Band D infections. ...

Chronic kidney diseases in mixed ancestry South African populations : prevalence, determinants and concordance between kidney function estimators

Matsha, Tandi E. Yako, Yandiswa Y. Rensburg, Megan A. Hassan, Mogamat S. Kengne, Andre P. Erasmus, Rajiv T. (BioMed Central, 2013-04)

ABSTRACT: Population-based data on the burden of chronic kidney disease (CKD) in sub-Saharan Africa is still very limited. We assessed the prevalence and determinants of CKD, and evaluated the concordance of commonly ...

Chronic kidney diseases in mixed ancestry South African populations : prevalence, determinants and concordance between kidney function estimators

Matsha, Tandi E. Yako, Yandiswa Y. Van Rensburg, Megan Hassan, Mogamat S. Kengne, Andre P. Erasmus, Rajiv T. (BioMed Central, 2013-04)

Background: Population-based data on the burden of chronic kidney disease (CKD) in sub-Saharan Africa is still very limited. We assessed the prevalence and determinants of CKD, and evaluated the concordance of commonly ...

Chronic myelomonocytic leukaemia: a case report

Getaz E.P. Staples W.G. (HMPG, 1977)

[No abstract available]

Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa

Ithete, Ndapewa Laudika Stoffberg, Samantha Corman, Victor Max Cottontail, Veronika M. Richards, Leigh Rosanne Schoeman, M. Corrie Drosten, Christian Drexler, Jan Felix Preiser, Wolfgang (Centers for Disease Control and Prevention (CDC), 2013-10)

We now report the identification of a South Africa bat derived CoV that has an even closer phylogenetic relationship with MERS-CoV.

Complex patterns of genomic admixture within Southern Africa

Petersen, Desiree C. Libiger, Ondrej Tindall, Elizabeth A. Hardie, Rae-Anne Hannick, Linda I. Glashoff, Richard H. Mukerji, Mitali Indian Genome Variation Consortium Fernandez, Pedro Haacke, Wilfrid Schork, Nicholas J. Hayes, Vanessa M. (PLOS, 2013-03)

Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly proportional to geographic distance. The most divergent contemporary human populations include the ...

The contribution of fine needle aspiration biopsy in the diagnosis of Mycobacterial Lymphadenopathy with particular reference to children

Wright, Colleen Anne (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: Expediting a diagnosis of tuberculosis in children, particularly those who are immunocompromised due to HIV/AIDS, is essential, as they are vulnerable to develop severe forms of disease due to their ...

The contribution of the placenta to the diagnosis of congenital tuberculosis

Rabie, Ursula (Stellenbosch : Stellenbosch University, 2014-04)

ENGLISH ABSTRACT: The aim of this pilot project was to determine whether mothers with laboratory confirmed or clinically suspected tuberculosis (TB) had evidence of TB in the placenta. A secondary objective was to ...

The conundrum of iron in multiple sclerosis – time for an individualised approach

Janse Van Rensburg, Susan Kotze, Maritha J. Van Toorn, Ronald (Springer US, 2012-03)

Although the involvement of immune mechanisms in multiple sclerosis (MS) is undisputed, some argue that there is insufficient evidence to support the hypothesis that MS is an autoimmune disease, and that the difference between ...

Coreceptor expression and T lymphocyte subset distribution in HIV-infected and TB co-infected South African patients on anti-retroviral therapy

Ngandu, Jean Pierre Kabue (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: In 2007, AIDS caused an estimated 2.1 millions deaths worldwide; about 70% in sub-Saharan Africa. HIV preferentially targets activated CD4 T cells, expressing the major HIV receptor CD4, as well as the ...

CYP2D6 genotyping and use of antidepressants in breast cancer patients : test development for clinical application

Van Der Merwe, Nicole Bouwens, Christianne S. H. Pienaar, Rika Van Der Merwe, Lize Yako, Yandiswa Y. Geiger, Dieter H. Kotze, Maritha J. (Springer Verlag, 2012-05)

Approximately 25 % of clinically important drugs and numerous environmental carcinogens are metabolised by CYP2D6. Variation in the CYP2D6 gene and concomitant use of tamoxifen (TAM) with certain antidepressants may increase ...

Cytokines and tuberculosis : an investigation of tuberculous lung tissue and a comparison with sarcoidosis

Bezuidenhout, Juanita (University of Stellenbosch. Faculty of Health Sciences. Dept. of Biomedical Sciences., 2005-12)

The formation of granulomas at the site of antigen presentation in both tuberculosis and sarcoidosis is an essential component of host immunity for controlling inflammation. Granuloma formation is a complex process that ...

Death certificates : let’s get it right!

Pieterse, Desiree Groenewald, Pam Bradshaw, Debbie Burger, Elsie H. Rohde, Jon Reagon, Gavin (Health and Medical Publishing Group (HMPG), 2009-09)

Determination of the permeability of biological membranes to various chemical markers, including anti-HIV drugs

Pretorius, Erina (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: Due to modern high-throughput technologies, large numbers of compounds are produced by parallel synthesis and combinatorial chemistry. The pharmaceutical industry therefore requires rapid and accurate ...

The development and application of a polymerase chain reaction (PCR) based assay to determine the impact of genetic variation in South African patients diagnosed with depression

Delport, Darnielle (Stellenbosch : Stellenbosch University, 2014-04)

ENGLISH ABSTRACT: Major Depressive Disorder (MDD) is a severe debilitating medical condition that may lead to suicide. Due to a poor understanding of the biological mechanisms underlying the disease process therapeutic ...

Development and validation of an in vitro model of dendritic cell identification and activation

Clark, Anel (Stellenbosch : Stellenbosch University, 2008-03)

ENGLISH ABSTRACT: The aim of this study was to investigate the effect of MBV and Coley’s Toxin on dendritic cells in vitro. The dendritic cell system of antigen presenting cells is the initiator and modulator of the ...

Development and validation of stabilized whole blood samples expressing T-cell activation markers as quality control reference material

Louw, Anne-Rika (Stellenbosch : Stellenbosch University, 2008-03)

ENGLISH ABSTRACT: Introduction: Flow cytometry has progressively replaced many traditional laboratory tests due to its greater accuracy, sensitivity and rapidity in the routine clinical settings especially clinical trails. ...

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