Browsing Department of Pathology by Title
Now showing items 29-48 of 257
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C-reactive protein. Properties and biological action with particular reference to systemic lupus erythematosus
(Health and Medical Publishing Group (HMPG), 1985)A dramatic increase in serum C-reactive protein levels occurs in response to specific bacterial infection or tissue damage. This protein forms part of the acute-phase response, and it appears to function as an independent ...
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Candida species : species distribution and antifungal susceptibility patterns
(Health and Medical Publishing Group (HMPG), 2008)[No abstract available]
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A century of trends in adult human height
(eLife Sciences Publications, 2016)ENGLISH SUMMARY : Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to ...
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The characterisation and expression of HIV-1 subtype C gag
(Stellenbosch : Stellenbosch University, 2002)ENGLISH ABSTRACT: The gag gene of HIV-1 encodes for one of the major structural proteins, which contains several conserved cytotoxic T cell (CTL) epitopes. Gag specific CTL responses are important in controlling viral ...
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Characterisation of new full-length HIV-1 subtype D viruses from South Africa
(2004-12)ENGLISH ABSTRACT: The first episode of HIV-1 in South Africa was documented in 1982. Homosexual transmission of the virus was the predominate mode of transmission in an epidemic of mainly HIV-1 subtype Band D infections. ...
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Characterisation of the HIV-1 subtype C Env gene and the expression of the Env protein from selected isolates in mammalian cells
(Stellenbosch : Stellenbosch University, 2003-03)ENGLISH ABSTRACT: At the end of 2002, human immunodeficiency virus (HIV) had infected 42 million people worldwide. The morbidity and mortality rate, as well as the epidemic proportions of the disease have led to ...
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Characteristics and outcome of children with juvenile dermatomyositis in Cape Town: a cross-sectional study
(BioMed Central, 2016-11-11)Background: Juvenile dermatomyositis (JDM) is a rare idiopathic inflammatory childhood myopathy of uncertain aetiology. The demographic and clinical presentation of JDM may differ by race and geographic regions. Few ...
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Chronic kidney diseases in mixed ancestry South African populations : prevalence, determinants and concordance between kidney function estimators
(BioMed Central, 2013-04)ABSTRACT: Population-based data on the burden of chronic kidney disease (CKD) in sub-Saharan Africa is still very limited. We assessed the prevalence and determinants of CKD, and evaluated the concordance of commonly ...
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Chronic kidney diseases in mixed ancestry South African populations : prevalence, determinants and concordance between kidney function estimators
(BioMed Central, 2013-04)Background: Population-based data on the burden of chronic kidney disease (CKD) in sub-Saharan Africa is still very limited. We assessed the prevalence and determinants of CKD, and evaluated the concordance of commonly ...
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Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa
(Centers for Disease Control and Prevention (CDC), 2013-10)We now report the identification of a South Africa bat derived CoV that has an even closer phylogenetic relationship with MERS-CoV.
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Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans : a cross sectional study
(BioMed Central, 2017-12-20)Background: Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease ...
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Complex patterns of genomic admixture within Southern Africa
(PLOS, 2013-03)Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly proportional to geographic distance. The most divergent contemporary human populations include the ...
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Construction of a high titer infectious HIV-1 subtype C proviral clone from South Africa
(MDPI, 2012-09-24)The Human Immunodeficiency Virus type 1 (HIV-1) subtype C is currently the predominant subtype worldwide. Cell culture studies of Sub-Saharan African subtype C proviral plasmids are hampered by the low replication capacity ...
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The contribution of fine needle aspiration biopsy in the diagnosis of Mycobacterial Lymphadenopathy with particular reference to children
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: Expediting a diagnosis of tuberculosis in children, particularly those who are immunocompromised due to HIV/AIDS, is essential, as they are vulnerable to develop severe forms of disease due to their ...
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The contribution of the placenta to the diagnosis of congenital tuberculosis
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: The aim of this pilot project was to determine whether mothers with laboratory confirmed or clinically suspected tuberculosis (TB) had evidence of TB in the placenta. A secondary objective was to ...
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The conundrum of iron in multiple sclerosis – time for an individualised approach
(Springer US, 2012-03)Although the involvement of immune mechanisms in multiple sclerosis (MS) is undisputed, some argue that there is insufficient evidence to support the hypothesis that MS is an autoimmune disease, and that the difference between ...
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Coreceptor expression and T lymphocyte subset distribution in HIV-infected and TB co-infected South African patients on anti-retroviral therapy
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: In 2007, AIDS caused an estimated 2.1 millions deaths worldwide; about 70% in sub-Saharan Africa. HIV preferentially targets activated CD4 T cells, expressing the major HIV receptor CD4, as well as the ...
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Correlation of post mortem LODOX digital radiological images with histopathological findings at autopsy : a prospective autopsy study at the Tygerberg Forensic Pathology Service Facility
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Background: The LODOX Statscan is a whole-body digital X-ray scanning device which was adapted for medical usage. The LODOX has an established role in the field of Forensic Pathology where it shows high ...
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CYP2D6 genotyping and use of antidepressants in breast cancer patients : test development for clinical application
(Springer Verlag, 2012-05)Approximately 25 % of clinically important drugs and numerous environmental carcinogens are metabolised by CYP2D6. Variation in the CYP2D6 gene and concomitant use of tamoxifen (TAM) with certain antidepressants may increase ...