Browsing Department of Pathology by Title

High prevalence of diabetes mellitus and metabolic syndrome in a South African coloured population : baseline data of a study in Bellville, Cape Town

Erasmus, Rajiv T. Soita, Rajiv T. Hassan, Mogamat S. Blanco-Blanco, Ernesto Vergotine, Zelda Kengne, Andre P. Matsha, Tandi E. (HMPG, 2012-11)

Objective. The coloured population has the second-highest prevalence of diabetes in South Africa. However, the data were based on a study conducted almost 20 years ago in a peri-urban coloured population of the Western ...

HIV Drug Resistance (HIVDR) in antiretroviral therapy-naive patients in Tanzania not eligible for WHO Threshold HIVDR survey is dramatically high

Kasang, Christa Kalluvya, Samuel Majinge, Charles Stich, August Bodem, Jochen Kongola, Gilbert Jacobs, Graeme Mlewa, Mathias Mildner, Miriam Hensel, Irina Horn, Anne Preiser, Wolfgang Van Zyl, Gert Klinker, Hartwig Koutsilieri, Eleni Rethwilm, Axel Scheller, Carsten Weissbrich, Benedikt (Public Library of Science (PLoS), 2011-08-19)

BACKGROUND: The World Health Organization (WHO) has recommended guidelines for a HIV drug resistance (HIVDR) survey for resource-limited countries. Eligibility criteria for patients include age below 25 years in order to ...

HIV-1 Subtypes B and C Unique Recombinant Forms (URFs) and transmitted drug resistance identified in the Western Cape Province, South Africa

Jacobs, Graeme. Brendon Wilkinson, Eduan Isaacs, Shahieda Spies, Georgina De Oliveira, Tulio Seedat, Soraya Engelbrecht, Susan (Public Library of Science, 2014-03)

South Africa has the largest worldwide HIV/AIDS population with 5.6 million people infected and at least 2 million people on antiretroviral therapy. The majority of these infections are caused by HIV-1 subtype C. Using ...

Identification of clinically-informative biomarkers within the spectrum of gastro-oesophageal reflux disease in the South African population

Van Rensburg, C. J. (Stellenbosch : University of Stellenbosch, 2006-03)

Patients with chronic gastro-oesophageal reflux disease are predisposed to Barrett’s metaplasia and oesophageal adenocarcinoma. The availability of molecular markers that can objectively identify patients with Barrett’s ...

Idiopathic thrombocytopenic purpura and hyperthyroidism : A case report

Getaz, E. P. Staples, W. G. (HMPG, 1977-08)

A case of immune thrombocytopenic purpura (ITP) and hyperthyroidism is presented. The treatment of refractory ITP with immunosuppressive agents is briefly considered. In 1931 a patient with coexistent purpura and ...

Improving laboratory techniques to detect M. tuberculosis complex and C. neoformans as the causative agents of chronic meningitis in cerebrospinal fluid of adult patients.

Prince, Yvonne (Stellenbosch : University of Stellenbosch, 2010-03)

ENGLISH ABSTRACT: INTRODUCTION Mycobacterium tuberculosis (MTB) and Cryptococcus neoformans are the most common causes of chronic meningitis in South Africa. Conventional microbiology has limited utility in diagnosing ...

In Vitro antimicrobial synergy testing of Acinetobachter Baumannii

Martin, Siseko (Stellenbosch : University of Stellenbosch, 2010-12)

ENGLISH ABSTRACT: Acinetobacter baumannii has emerged as one of the most troublesome nosocomial pathogens globally. This organism causes infections that are often extremely difficult to treat because of the widespread ...

An in vitro investigation of the anti-inflammatory and immunosuppressive effects of the synthetic contraceptives medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A)

Kriek, W. J. (Stellenbosch : University of Stellenbosch, 2005-03)

The aim of this study was to investigate the anti-inflammatory and immunosuppressive effects of the synthetic progestins, MPA and NET-A on human cells in vitro. These injectable contraceptives are used extensively ...

In-house genotypic antiretroviral resistance test : optimisation and validation for use in research and diagnostics

Claassen, Mathilda (Stellenbosch : University of Stellenbosch, 2011-03)

It is estimated that 32.8 million people are living with Human Immunodeficiency Virus (HIV) globally with the number of people receiving antiretroviral therapy in low- and middle- income counties increasing to more than ...

The inhibition of the Human Immunodeficiency Virus type 1 activity by crude and purified human pregnancy plug mucus and mucins in an inhibition assay

Habte, Habtom H. De Beer, Corena Lotz, Zoe E. Tyler, Marilyn G. Schoeman, Leann Kahn, Delawir Mall, Anwar S. (BioMed Central, 2008-05)

Background: The female reproductive tract is amongst the main routes for Human Immunodeficiency Virus (HIV) transmission. Cervical mucus however is known to protect the female reproductive tract from bacterial invasion and ...

The intimate relationship between man and yeast : it's complicated

Botha, Alfred (Stellenbosch : University of Stellenbosch, 2011-06)

Inaugural address delivered on 6 June 2011 by prof Alf Botha.Yeasts public health service; resource allocation; have been associated with mankind’s welfare for a long time. For millennia these unicellular fungi were ...

Investigating the aetiology of respiratory tract infections in children admitted to Tygerberg Children’s Hospital using molecular methods and viral culture

Maree, Leana (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Introduction Acute respiratory tract infections cause significant morbidity and mortality worldwide, and are the main reason for the utilisation of health care services. Identifying the aetiological ...

The investigation of genotypic antiretroviral drug resistance in the context of the South African national antiretroviral roll-out programme

Van Zyl, Gert Uves (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Introduction: Since the South African public sector antiretroviral roll-out programme started in 2004, the success of antiretroviral combination therapy (cART) has been experienced in terms of survival, ...

An investigation of hepatitis B virus in antenatal women tested for human immunodeficiency virus, in the Western Cape Province of South Africa

Maponga, Tongai Gibson (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Hepatitis B virus (HBV) immunisation protocols in much of Africa are based on data from the pre-human immunodeficiency virus (pre-HIV) era that indicated that HBV transmission occurs predominantly ...

Investigation of small mammal-borne viruses with zoonotic potential in South Africa

Ithete, Ndapewa Laudika (Stellenbosch : Stellenbosch University, 2013-12)

ENGLISH ABSTRACT: The emergence and re-emergence of viral human pathogens from wildlife sources in the recent past has led to increased studies and surveillance of wildlife for potentially zoonotic agents in order to gain ...

Investigation of the molecular epidemiology of HIV-1 in Khayelitsha, Cape Town, using serotyping and genotyping techniques

Jacobs, Graeme Brendon (Stellenbosch : University of Stellenbosch, 2005-12)

There are currently an estimated 5.3 million people infected with human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) in South Africa. HIV-1 group M Subtype C is currently responsible for the ...

Investigation of the relationship between genetic and environmental risk factors associated with obesity and insulin resistance in South African patients with non-alcoholic fatty liver disease(NAFLD)

Pretorius, Jakobus (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The disease spectrum of NAFLD extends from steatosis (types 1,2) to non-alcoholic steatohepatitis (NASH) ...

Involving African traditional health practitioners in HIV/AIDS interventions

Wreford, J. Esser, M. (Health and Medical Publishing Group (HMPG), 2008)

[No abstract available]

Irreproducible positive results on the Cobas AmpliPrep/Cobas TaqMan HIV-1 Qual test are qualitatively different from confirmed positive results

Maritz, Jean (2013-10)

Criteria that define low positive results on the COBAS® AmpliPrep/COBAS® TaqMan (CAP/CTM) HIV- 1 Qual test as inconclusive have been adopted by all academic centres in South Africa that conduct infant HIV PCR, following ...

Laboratoriumstandaardisasie en kwaliteitskontrole in antistolterapie

Brink S. Cloete H. Roberts R. Holm W. (HMPG, 1976-02)

[No abstract available]

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