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Circadian rhythms as novel chemotherapeutic strategies for breast cancer

Mitchell, Megan Irvette (Stellenbosch : Stellenbosch University, 2014-12)

ENGLISH ABSTRACT: Introduction: Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. ...

Metabolic reprograming and cancer resistance : an investigation into the metabolic control of cancer-associated fibroblasts on breast cancer cell survival and metastasis

Mitchell, Megan Irvette (Stellenbosch : Stellenbosch University, 2018-03)

ENGLISH ABSTRACT: Introduction: Cancer-associated fibroblasts (CAFs) constitute the most abundant mesenchymal cell type present within the tumour microenvironment. Recent evidence suggests that nutrient deprived cancer ...