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11β-Hydroxyandrostenedione returns to the steroid arena : biosynthesis, metabolism and function
(MDPI, 2013-10)
The biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway ...
A structure/function investigation into baboon cytochrome P450 side-chain cleavage (CYP11A1)
(Stellenbosch : University of Stellenbosch, 2005-12)
This study describes:
1. The cloning of baboon cytochrome P450 side-chain cleavage (CYP11A1) cDNA by in
vitro site-directed mutagenesis.
2. The identification and sequencing of three baboon CYP11A1 mutants: CYP11A1a,
CYP11A1b ...
The influence of dual CYP17 expression on adrenal steroidogenesis in the South African Angora Goat
(Stellenbosch : Stellenbosch University, 2008-12)
This study describes:
• the cloning and sequencing of cytochrome P450 17 -hydroxylase/17,20
lyase (CYP17), 3 -hydroxysteroid dehydrogenase (3 HSD) and
cytochrome b5 from the South African Angora goat;
• the identification ...
11-ketotestosterone and 11-ketodihydrotestosterone in castration resistant prostate cancer : potent androgens which can no longer be ignored
(Public Library of Science, 2016)
Dihydrotestosterone (DHT) is regarded as the most potent natural androgen and is implicated in the development and progression of castration resistant prostate cancer (CRPC). Under castrate conditions, DHT is produced from ...
Fourth-generation progestins inhibit 3β-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids
(Public Library of Science, 2016-05)
Progestins used in contraception and hormone replacement therapy are synthetic compounds designed to mimic the actions of the natural hormone progesterone and are classed into four consecutive generations. The biological ...