Now showing items 1-6 of 6
Is mammalian chromosomal evolution driven by regions of genome fragility?
(BioMed Central, 2006-12)
Background: A fundamental question in comparative genomics concerns the identification of mechanisms that underpin chromosomal change. In an attempt to shed light on the dynamics of mammalian genome evolution, we analyzed ...
Western Zambian sable : are they a geographic extension of the giant sable antelope
(South African Wildlife Management Association, 2010-04)
The giant sable (Hippotragus niger variani) is one of Africa's most spectacular large antelope. Years of civil unrest in Angola, a highly localized distribution and Interbreeding with its congener the roan antelope (H. ...
Chromosomal instability in Afrotheria : fragile sites, evolutionary breakpoints and phylogenetic inference from genome sequence assemblies
(BioMed Central, 2007-10)
Background: Extant placental mammals are divided into four major clades (Laurasiatheria, Supraprimates, Xenarthra and Afrotheria). Given that Afrotheria is generally thought to root the eutherian tree in phylogenetic ...
Evolutionary history of LINE-1 in the major clades of placental mammals
(Public Library of Science (PLOS), 2007-01)
Background. LINE-1 constitutes an important component of mammalian genomes. It has a dynamic evolutionary history characterized by the rise, fall and replacement of subfamilies. Most data concerning LINE-1 biology and ...
Y-Chromosome Variation in Hominids: Intraspecific Variation Is Limited to the Polygamous Chimpanzee
Background: We have previously demonstrated that the Y-specific ampliconic fertility genes DAZ (deleted in azoospermia) and CDY (chromodomain protein Y) varied with respect to copy number and position among chimpanzees ...
Evolution from XIST-independent to XIST-controlled X-chromosome inactivation : epigenetic modifications in distantly related mammals
(Public Library of Science, 2011-04-25)
X chromosome inactivation (XCI) is the transcriptional silencing of one X in female mammals, balancing expression of X genes between females (XX) and males (XY). In placental mammals non-coding XIST RNA triggers silencing ...