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Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ
(2014-10)
Corticosteroid-binding globulin (CBG), a negative acute phase protein produced primarily in the liver, is responsible for the transport of glucocorticoids (GCs). It also modulates the bioavailability of GCs, as only free ...
Evaluation of the phytoestrogenic activity of Cyclopia genistoides (honeybush) methanol extracts and relevant polyphenols
(American Chemical Society, 2007-04)
Unfermented C. genistoides methanol extracts of different harvestings and selected polyphenols were evaluated for phytoestrogenic activity by comparing binding to both ER subtypes, transactivation of an ERE-containing ...
Screening of four Cyclopia (honeybush) species for putative phyto-oestrogenic activity by oestrogen receptor binding assays
(AOSIS OpenJournals, 2007)
Phyto-oestrogens mediate an oestrogenic effect through binding to the oestrogen receptor (ER) subtypes, ERα and ERβ. Four commercially available Cyclopia (honeybush) species - C. intermedia, C. subternata, C. genistoides ...
Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats
(The Endocrine Society, 1999-05)
Salsola tuberculatiformis Botschantzev causes prolonged gestation
in sheep and contraception in rats. An active fraction isolated
from the shrub, containing a highly labile hydoxyphenyl aziridine or
precursor, and a ...
Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution
(Elsevier, 2013-02)
Glucocorticoid receptor (GR) concentrations and the ability of the GR to dimerize are factors which influence
sensitivity to glucocorticoids. Upon glucocorticoid binding, the GR is actively transported into the
nucleus, ...
Inhibition of cytochrome P450c11 by biogenic amines and an aziridine precursor, 2-(4-acetoxyphenyl_-2-chloro-n-methyl-ethylammonium chloride
(Informa Healthcare, 2000)
The interaction of several biogenic amines and Compound A (2-(4-acetoxyphenyl)-2-chloro- N-methyl-ethylammonium chloride), an analogue of the active substance in a HPLC fraction isolated from the shrub, Salsola tuberculatiformis ...
Illuminating the interrelated immune and endocrine adaptations after multiple exposures to short immobilization stress by in vivo blocking of IL-6
(American Physiological Society, 2006-12)
ACUTE PSYCHOLOGICAL STRESS is known to activate the hypothalamic-
pituitary-adrenal (HPA) axis, resulting in transiently increased
release of inflammatory cytokines (28) and glucocorticoids
(45). In contrast, multiple ...
Interplay of the inflammatory and stress systems in a hepatic cell line : interactions between glucocorticoid receptor agonists and interleukin-6
(HighWire Press, 2010-11)
The liver plays an important role in inflammation and stress by producing the acute phase proteins
(APPs) required for resolution of inflammation as well as by delivering systemic glucose, through
gluconeogenesis, required ...
Not all progestins are the same : implications for usage
(Elsevier, 2004-11)
Recent clinical evidence showing unexpected side-effects
of progestins used in contraception and hormone replacement
therapy has highlighted the importance of choice of
synthetic progestin. The molecularmechanisms of ...
South African herbal teas : Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - a review
(Elsevier, 2008-10)
Rooibos (Aspalathus linearis (Brum.f) Dahlg.) and honeybush (Cyclopia Vent. species) are popular indigenous
South African herbal teas enjoyed for their taste and aroma. Traditional medicinal uses of rooibos in
South ...