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Cell death in hyppxic injury : signaling mechanisms and dynamics in the decision making process
(Stellenbosch : University of Stellenbosch, 2009-12)
ENGLISH ABSTRACT: Three main morphologies of cell death have been described in the diseased
myocardium, type I, better known as apoptotic cell death, which is characterized by
cell shrinkage and chromatin condensation, ...
St John’s Wort (Hypericum perforatum L.) photomedicine : hypericin-photodynamic therapy induces metastatic melanoma cell death
(PLoS, 2014-07-30)
Hypericin, an extract from St John's Wort (Hypericum perforatum L.), is a promising photosensitizer in the context of clinical photodynamic therapy due to its excellent photosensitizing properties and tumoritropic ...
Bcl‑2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose‑dependent toxicity and resistance
(BioMed Central, 2015-10)
Background: Cisplatin is the main chemotherapeutic drug for the treatment of cervical cancers, however resistance
to cisplatin is increasingly common and therefore has limited the efficacy and use of this drug in the ...
Signalling mechanisms involved in TNF-α mediated cytoprotection during ischaemic injury in a C2C12 muscle cell line
(Stellenbosch : University of Stellenbosch, 2006-12)
ENGLISH ABSTRACT: Both, the cytokine Tumor Necrosis Factor-α (TNF-α) and the enzyme cytosolic
phospholipase A2 (cPLA2) are crucial driving forces in mediating the cellular
inflammatory response and are involved in ischaemic ...