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Not all progestins are the same : implications for usage
(Elsevier, 2004-11)
Recent clinical evidence showing unexpected side-effects
of progestins used in contraception and hormone replacement
therapy has highlighted the importance of choice of
synthetic progestin. The molecularmechanisms of ...
Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A
(HighWire Press, 2010-03)
Compound A (CpdA), a dissociated glucocorticoid receptor
modulator, decreases corticosteroid-binding globulin (CBG),
adrenocorticotropic hormone (ACTH), and luteneinizing
hormone levels in rats. Whether this is due to ...
The injectable-only contraceptive medroxyprogesterone acetate, unlike norethisterone acetate and progesterone, regulates inflammatory genes in endocervical cells via the glucocorticoid receptor
(PLoS, 2014-05-19)
Clinical studies suggest that the injectable contraceptive medroxyprogesterone acetate (MPA) increases susceptibility to infections such as HIV-1, unlike the injectable contraceptive norethisterone enanthate (NET-EN). We ...
Fourth-generation progestins inhibit 3β-hydroxysteroid dehydrogenase type 2 and modulate the biosynthesis of endogenous steroids
(Public Library of Science, 2016-05)
Progestins used in contraception and hormone replacement therapy are synthetic compounds designed to mimic the actions of the natural hormone progesterone and are classed into four consecutive generations. The biological ...