Search
Now showing items 1-10 of 15
Differential tolerance of a cancer and a non-cancer cell line to amino acid deprivation : mechanistic insight and clinical potential
(Stellenbosch : Stellenbosch University, 2012-03)
ENGLISH ABSTRACT: Introduction – Due to spatial separation from the native vascular bed, solid tumours develop regions with limited access to nutrients essential for growth and survival. The promotion of a process known ...
A comparison of the effect of curcumin treatment on apoptosis, necrosis and autophagy in a MCF-7 mammary adenocarcinoma and a MCF-12A healthy mammary epithelial cell line
(Stellenbosch : University of Stellenbosch, 2009-03)
Breast cancer is currently the primary cause of cancer-related death in women
worldwide. Conventional treatments such as radiation and chemotherapy have many
deleterious and long lasting side-effects, some of which are ...
Circadian rhythms as novel chemotherapeutic strategies for breast cancer
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Introduction: Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. ...
Anthracycline-induced cardiotoxicity : the role of proteolytic pathways
(Stellenbosch : Stellenbosch University, 2012-03)
ENGLISH ABSTRACT: Introduction: The anthracyclines (ACs), daunorubicin (DNR) and doxorubicin (DXR)
are two of the most effective drugs known for the treatment of systemic neoplasms
and solid tumours. However, their ...
Acute simulated hypoxia and ischemia in cultured C2C12 myotubes : decreased phosphatidylinositol 3-kinase (PI3K)/Akt activity and its consequences for cell survival
(Stellenbosch : Stellenbosch University, 2008-12)
Cells are equipped with an array of adaptive mechanisms to contest the undesirable effects of
ischemia and the associated hypoxia. Indeed, many studies have suggested that there is an
increase in the PI3K/Akt pathway ...
The role of MKP-1 in autophagy, apoptosis and necrosis during ischaemia/reperfusion injury in the heart
(2010-12)
ENGLISH ABSTRACT: Ischaemic heart disease is a leading cause of death worldwide and is also
largely contributing to deaths in Africa. Better treatment or even prevention of
ischaemia/reperfusion injury in the heart, ...
Cell death in hyppxic injury : signaling mechanisms and dynamics in the decision making process
(Stellenbosch : University of Stellenbosch, 2009-12)
ENGLISH ABSTRACT: Three main morphologies of cell death have been described in the diseased
myocardium, type I, better known as apoptotic cell death, which is characterized by
cell shrinkage and chromatin condensation, ...
Repetitive stressors at various lifetime periods differentially affect the HPA axis, neuronal neurotrophic factors and behavioural responses
(Stellenbosch : University of Stellenbosch, 2006-03)
Early adverse life events appear to increase the susceptibility of developing psychiatric disorders later in life. The molecular mechanisms involved in the development of pathological behaviour remain unclear. Dysregulation ...
The role of short-term starvation in sensitizing breast cancer to chemotherapy
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Introduction: Breast cancer is a major contributor to mortality in women worldwide. Although, anthracyclines, such as doxorubicin, are among the most valuable treatments for breast cancer, their clinical ...
The relationship between HIF-1α and autophagy activity in the hypoxic environment of breast cancer
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Introduction:
Among the cancers that afflict females world-wide, neoplastic disease of breast tissue is the most frequently diagnosed form and the leading cause of cancer-related death. Conventional ...