Browsing Faculty of Science by Title

1-tert-Butyl 2-ethyl 5-bromo-3-(thiophen-2-ylcarbonyl)-1H-indole-1,2-dicarboxylate

Hassam, Mohammad; Smith, Vincent J. (International Union of Crystallography, 2013-01-16)

ENGLISH ABSTRACT: In the title compound, C21H20BrNO5S, the thiophene group is located above the mean plane of the indole ring and displays rotational disorder (i.e. rotation through 180). The site occupancy of the major ...

11-ketotestosterone and 11-ketodihydrotestosterone in castration resistant prostate cancer : potent androgens which can no longer be ignored

Pretorius, Elzette; Africander, Donita J.; Vlok, Mare; Perkins, Meghan S.; Quanson, Jonathan; Storbeck, Karl-Heinz (Public Library of Science, 2016)

Dihydrotestosterone (DHT) is regarded as the most potent natural androgen and is implicated in the development and progression of castration resistant prostate cancer (CRPC). Under castrate conditions, DHT is produced from ...

11β-Hydroxyandrostenedione returns to the steroid arena : biosynthesis, metabolism and function

Bloem, Liezl M.; Storbeck, Karl-Heinz; Schloms, Lindie; Swart, Amanda C. (MDPI, 2013-10)

The biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway ...

A 195Pt Nuclear magnetic resonance and molecular dynamics computer simulation study of the solvation of simple platinum (IV) chlorido complex anions in water and water-miscible solvent mixtures

Engelbrecht, Leon de Villiers (2017-03)

ENGLISH ABSTRACT: A combined 195Pt NMR spectroscopy and Molecular Dynamics (MD) computer simulation study of the solvation of the octahedral Pt(IV) complex [PtCl6]2‒ in binary mixtures of water and the fully water-miscible ...

2020-12-31 Thermal biology of the invasive ladybird Harmonia axyridis : physiological plasticity, thermoregulatory behaviour and fitness

Shinner, Rebecca (Stellenbosch : Stellenbosch University, 2014-12)

ENGLISH ABSTRACT: Physiological and behavioural responses to changes in temperature may enable ectotherms to buffer the effects of climate change or facilitate movement into novel environments. The thermal biology of the ...

36 Chlorine isotope systematics in saline groundwater in the Buffels River Valley

Van Gend, Jani (Stellenbosch : Stellenbosch University, 2018-03)

ENGLISH ABSTRACT: It is typical for coastal aquifers in arid regions to be affected by salinisation, populations in these areas that rely upon groundwater resources are often directly afflicted by this phenomenon. Large ...

3D numerical techniques for determining the foot of a continental slope

Pantland, Nicolette Ariana (Stellenbosch : Stellenbosch University, 2004-12)

ENGLISH ABSTRACT: The United Nations Convention on the Law of the Sea (UNCLOS) provides an opportunity for qualifying coastal signatory states to claim extended maritime estate. The opportunity to claim rests on the ...

A 3D Virtual Environment Development Platform for ASD Therapy Tools

Chamberlain, Morne Edward (Stellenbosch : University of Stellenbosch, 2009-12)

ENGLISH ABSTRACT: The aim of this thesis is to develop a generic 3D virtual environment development platform for autism spectrum disorder (ASD) therapy tools. The potential of using computerised therapy tools for ASD ...

50 years of Emmonsia disease in humans : the dramatic emergence of a cluster of novel fungal pathogens

Schwartz, Ilan S.; Kenyon, Chris; Feng, Peiying; Govender, Nelesh P.; Dukik, Karolina; Sigler, Lynne; Jiang, Yanping; Stielow, J. Benjamin; Munoz, Jose F.; Cuomo, Christina A.; Botha, Alfred; Stchigel, Alberto M.; De Hoog, G. Sybren (Public Library of Science, 2015)

New species of Emmonsia-like fungi, with phylogenetic and clinical similarities to Blastomyces and Histoplasma, have emerged as causes of systemic human mycoses worldwide. They differ from classical Emmonsia species by ...

A fully dissociated compound of plant origin for inflammatory gene repression

De Bosscher, Karolien; Van den Berghe, Wim; Beck, Ilse M. E.; Van Molle, Wim; Hennuyer, Nathalie; Hapgood, Janet; Liber, Claude; Staels, Bart; Louw, Ann; Haegeman, Guy (PNAS, 2005-11)

The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating ...

A study on the reversible photo-induced isomerisation of platinum(II) and palladium(II) complexes of the N,N-dialkyl-N’-acyl(aroyl)thioureas with reversed-phase HPLC separation from related rhodium(III), ruthenium(III) and iridium(III) complexes

Nkabyo, Henry Ane (Stellenbosch : Stellenbosch University, 2014-04)

ENGLISH ABSTRACT: See item for full text

AB diblock copolymers via RAFT-mediated miniemulsion polymerization

Bailly, Nathalie (Stellenbosch : Stellenbosch University, 2008-12)

The Reversible addition fragmentation chain transfer (RAFT) technique is a robust and versatile technique that enables the synthesis of polymers of controlled molecular weight and polydispersity. The application of the ...

An Ab Initio density functional study of the structure and stability of transition metal ozone complexes

Venter, Gerhard (Gerhard Abraham) (Stellenbosch : Stellenbosch University, 2002-12)

ENGLISH ABSTRACT: A thorough search through the literature as well as through the Cambridge Crystallographic Structural Database resulted in no examples of a neutral ozone acting as ligand in a complex with any metal. ...

The ability of antimicrobial peptides to migrate across the gastrointestinal epithelial and vascular endothelial barriers

Dreyer, Leane (Stellenbosch : Stellenbosch University, 2018-03)

ENGLISH ABSTRACT: Antibiotic resistance has become a major threat to humankind, necessitating research and development of alternative antimicrobial compounds. Many bacteria, including lactic acid bacteria, produce small ...

The ability of terrestrial Oligochaeta to survive in ultramafic soils and the assessment of toxicity at different levels of organisation

Maleri, Rudolf A. (Stellenbosch : University of Stellenbosch, 2006-12)

Metals are natural elements of the earth crust usually present at low concentrations in all soils. Although many metals such as cobalt, copper, iron and zinc are essential to living organisms, at elevated concentrations ...