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Now showing items 1-6 of 6

Antimycobacterial agents : a study of Liposomal-Encapsulation, comparitive permeability of bronchial tissue and in vitro activity against mycobacterium tuberculosis isolates

Van Rensburg, Lyne (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: In this thesis, research results are reported on the role of dipalmitoyl phosphatidyl choline (DPPC) and DPPC-liposomes on the in vitro permeability characteristics of various antimycobacterial drugs ...
A critical appraisal of the clinical pharmacokinetics of isoniazid

Parkin, Donald Pysden (Stellenbosch : University of Stellenbosch, 1996-12)

The work presented in this thesis has contributed to the clarification of a number of issues related to the clinical pharmacokinetics of isoniazid and hydrozine in juvenile and adult patients of both sexes subject to ...
Drug-drug interactions between antiretrovirals and fluconazole in HIV-infected patients

Fouche, Desire (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Background: HIV-positive patients have a significantly weakened immune system which makes them highly susceptible for opportunistic infections, requiring additional treatment. Cryptococcal meningitis ...
Effect of ultrasound on transdermal permeation of diclofenac and the temperature effects on human skin

Basson, Erina (Stellenbosch : University of Stellenbosch, 2005-12)

During the last two decades the effects of ultrasound on the transdermal diffusion of a wide variety of drugs have been extensively investigated. Because there is much uncertainty regarding the efficacy of and mechanisms ...
Pharmacokinetics and dosing rationale of Para-Aminosalicylic acid in children and the evaluation of the in vitro metabolism of Ethionamide, Terizidone and Para-aminosalicylic acid

Liwa, Anthony Cuthbert (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: BACKGROUND: The emergence of mycobacterium tuberculosis resistance to first line drugs has renewed interest in second-line anti-tuberculosis drugs. Generally, Paraaminosalicylic acid (PAS) is less ...
The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds

Viljoen, Ianda (Stellenbosch : University of Stellenbosch, 2005-12)

In this thesis, research results are reported on the role of natural and synthetic surfactants on the in vitro permeability characteristics of various chemical compounds across porcine (buccal, bronchial, arterial, venous ...