Now showing items 1-3 of 3
Anti-inflammatory effects of reactive oxygen species : a multi-valued logical model validated by formal concept analysis
(BioMed Central, 2014-09)
Background: Recent findings suggest that in pancreatic acinar cells stimulated with bile acid, a pro-apoptotic effect of reactive oxygen species (ROS) dominates their effect on necrosis and spreading of inflammation. The ...
Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice
Reactive oxygen species (ROS) have been implicated in the pathogenesis of acute pancreatitis (AP) for many years but experimental evidence is still limited. Uncoupling protein 2 (UCP2)-deficient mice are an accepted model ...
Parameter identifiability and sensitivity analysis predict targets for enhancement of STAT1 activity in pancreatic cancer and stellate cells
(Public Library of Science, 2012-12)
The present work exemplifies how parameter identifiability analysis can be used to gain insights into differences in experimental systems and how uncertainty in parameter estimates can be handled. The case study, presented ...