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Browsing Research Articles (Stellenbosch Institute for Advanced Studies) by Title

Now showing items 1-20 of 36

    • After Fukushima : the precautionary principle revisited 

      Huber, Wolfgang (AOSIS Publishing, 2012-12-06)
      Etienne de Villiers, more than other theologians, elaborates on basic elements of a Christian ethics of responsibility. He distinguishes between retrospective and prospective responsibility. The prospective aspect attracted ...

    • Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice 

      Muller, Sarah; Kaiser, Hannah; Kruger, Burkhard; Fitzner, Brit; Lange, Falko; Bock, Cristin N.; Nizze, Horst; Ibrahim, Saleh M.; Fuellen, Georg; Wolkenhauer, Olaf; Jaster, Robert (PLoS, 2014-04-10)
      Reactive oxygen species (ROS) have been implicated in the pathogenesis of acute pancreatitis (AP) for many years but experimental evidence is still limited. Uncoupling protein 2 (UCP2)-deficient mice are an accepted model ...

    • Annotation-based feature extraction from sets of SBML models 

      Alm, Rebekka; Waltemath, Dagmar; Wolfien, Markus; Wolkenhauer, Olaf; Henkel, Ron (BioMed Central, 2015-04-15)
      Background: Model repositories such as BioModels Database provide computational models of biological systems for the scientific community. These models contain rich semantic annotations that link model entities to concepts ...

    • Anti-inflammatory effects of reactive oxygen species : a multi-valued logical model validated by formal concept analysis 

      Wollbold, Johannes; Jaster, Robert; Muller, Sarah; Rateitschak, Katja; Wolkenhauer, Olaf (BioMed Central, 2014-09)
      Background: Recent findings suggest that in pancreatic acinar cells stimulated with bile acid, a pro-apoptotic effect of reactive oxygen species (ROS) dominates their effect on necrosis and spreading of inflammation. The ...

    • The archaeology of teaching and the evolution of Homo docens 

      Gardenfors, Peter; Hogberg, Anders (University of Chicago Press, 2017-4)
      Teaching is present in all human societies, while within other species it is very limited. Something happened during the evolution of Homo sapiens that also made us Homo docens—the teaching animal. Based on discussions ...

    • COMODI : an ontology to characterise differences in versions of computational models in biology 

      Scharm, Martin; Waltemath, Dagmar; Mendes, Pedro; Wolkenhauer, Olaf (BioMed Central, 2016-07-11)
      Background: Open model repositories provide ready-to-reuse computational models of biological systems. Models within those repositories evolve over time, leading to different model versions. Taken together, the underlying ...

    • Consumer-resource dynamics : quantity, quality, and allocation 

      Getz, Wayne M.; Owen-Smith, Norman (Public Library of Science, 2011-01-20)
      Background: The dominant paradigm for modeling the complexities of interacting populations and food webs is a system of coupled ordinary differential equations in which the state of each species, population, or functional ...

    • Death domain signaling by disulfide-linked dimers of the p75 neurotrophin receptor mediates neuronal death in the CNS 

      Tanaka, Kazuhiro; Kelly, Claire E.; Goh, Ket Yin; Lim, Kim Buay; Ibanez, Carlos F. (Society for Neuroscience, 2016-05-18)
      The p75 neurotrophin receptor (p75NTR) mediates neuronal death in response to neural insults by activating a caspase apoptotic pathway. The oligomeric state and activation mechanism that enable p75NTR to mediate these ...

    • Declaration on mental health in Africa : moving to implementation 

      Daar, Abdallah S.; Jacobs, Marian; Wall, Stig; Groenewald, Johann; Eaton, Julian; Patel, Vikram; Dos Santos, Palmira; Kagee, Ashraf; Gevers, Anik; Sunkel, Charlene; Andrews, Gail; Daniels, Ingrid; Ndetei, David (Co-Action Publishing, 2014-06-16)
      Urgent action is needed to address mental health issues globally. In Africa, where mental health disorders account for a huge burden of disease and disability, and where in general less than 1% of the already small health ...

    • “Deeper into a hole?” : borrowing and lending in South Africa 

      James, Deborah (University of Chicago Press Journals, 2014-08)
      In South Africa, with upward mobility much aspired to but seldom attained, householders must spend money they have not yet earned. Borrowing both from formal institutions and smaller moneylenders (legal and illegal) positions ...

    • Dissecting long-term glucose metabolism identifies new susceptibility period for metabolic dysfunction in aged mice 

      Chauhan, Anuradha; Weiss, Heike; Koch, Franziska; Ibrahim, Saleh M.; Vera, Julio; Wolkenhauer, Olaf; Tiedge, Markus (Public Library of Science, 2015)
      Metabolic disorders, like diabetes and obesity, are pathogenic outcomes of imbalance in glucose metabolism. Nutrient excess and mitochondrial imbalance are implicated in dysfunctional glucose metabolism with age. We used ...

    • Enabling multiscale modeling in systems medicine 

      Wolkenhauer, Olaf; Auffray, Charles; Brass, Olivier; Clairambault, Jean; Deutsch, Andreas; Drasdo, Dirk; Gervasio, Francesco; Preziosi, Luigi; Maini, Philip; Marciniak-Czochra, Anna; Kossow, Christina; Kuepfer, Lars; Rateitschak, Katja; Ramis-Conde, Ignacio; Ribba, Benjamin; Schuppert, Andreas; Smallwood, Rod; Stamatakos, Georgios; Winter, Felix; Byrne, Helen (BioMed Central, 2014-03)
      [See article for abstract].

    • Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries 

      Ocklenburg, Sebastian; Schmitz, Judith; Moinfar, Zahra; Moser, Dirk; Klose, Rena; Lor, Stephanie; Kunz, Georg; Tegenthoff, Martin; Faustmann, Pedro; Francks, Clyde; Epplen, Jorg T.; Kumsta, Robert; Gunturkun, Onur (eLife Sciences Publications, 2017)
      Lateralization is a fundamental principle of nervous system organization but its molecular determinants are mostly unknown. In humans, asymmetric gene expression in the fetal cortex has been suggested as the molecular basis ...

    • Evolution of computational models in BioModels Database and the Physiome Model Repository 

      Scharm, Martin; Gebhardt, Tom; Toure, Vasundra; Bagnacani, Andrea; Salehzadeh-Yazdi, Ali; Wolkenhauer, Olaf; Waltemath, Dagmar (BioMed Central, 2018-04-12)
      ENGLISH SUMMARY : Background: A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and ...

    • General criterion for harmonicity 

      Proesmans, Karel; Vandebroek, Hans; Van Den Broeck, Christian (American Physical Society, 2017)
      Inspired by Kubo-Anderson Markov processes, we introduce a new class of transfer matrices whose largest eigenvalue is determined by a simple explicit algebraic equation. Applications include the free energy calculation for ...

    • How spatial scale shapes the generation and management of multiple ecosystem services 

      Lindborg, Regina; Gordon, Line J.; Malinga, Rebecka; Bengtsson, Jan; Peterson, Garry; Bommarco, Riccardo; Deutsch, Lisa; Gren, Asa; Rundlof, Maj; Smith, Henrik G. (Ecological Society of America, 2017)
      The spatial extent of ecological processes has consequences for the generation of ecosystem services related to them. However, management often fails to consider issues of scale when targeting ecological processes underpinning ...

    • Image-based mHealth for remote diagnostic assistance a means to promote equity in quality care 

      Laflamme, Lucie (Taylor & Francis Open, 2017)
      No abstract

    • Medical mobile technologies – what is needed for a sustainable and scalable implementation on a global scale? 

      Lundin, Johan; Dumont, Guy (Taylor & Francis Open, 2017)
      Current advances within medical technology show great potential from a global health perspective. Inexpensive, effective solutions to common problems within diagnostics, medical procedures and access to medical information ...

    • Observed full blood count and lymphocyte subset values in a cohort of clinically healthy South African children from a semi-informal settlement in Cape Town 

      Lawrie, Denise; Payne, Helen; Nieuwoudt, Martin; Glencross, Deborah Kim (Health & Medical Publishing Group, 2015-09)
      Background. The paediatric full blood count and lymphocyte subset reference intervals used by the National Health Laboratory Service (NHLS), South Africa (SA), are taken from two international reference interval publications. ...

    • On the modularity of the intrinsic flexibility of the µ opioid receptor : a computational study 

      Fossepre, Mathieu; Leherte, Laurence; Laaksonen, Aatto; Vercauteren, Daniel P. (Public Library of Science, 2015)
      The µ opioid receptor (µOR), the principal target to control pain, belongs to the G protein-coupled receptors (GPCRs) family, one of the most highlighted protein families due to their importance as therapeutic targets. The ...