• Death domain signaling by disulfide-linked dimers of the p75 neurotrophin receptor mediates neuronal death in the CNS 

      Tanaka, Kazuhiro; Kelly, Claire E.; Goh, Ket Yin; Lim, Kim Buay; Ibanez, Carlos F. (Society for Neuroscience, 2016-05-18)
      The p75 neurotrophin receptor (p75NTR) mediates neuronal death in response to neural insults by activating a caspase apoptotic pathway. The oligomeric state and activation mechanism that enable p75NTR to mediate these ...
    • Declaration on mental health in Africa : moving to implementation 

      Daar, Abdallah S.; Jacobs, Marian; Wall, Stig; Groenewald, Johann; Eaton, Julian; Patel, Vikram; Dos Santos, Palmira; Kagee, Ashraf; Gevers, Anik; Sunkel, Charlene; Andrews, Gail; Daniels, Ingrid; Ndetei, David (Co-Action Publishing, 2014-06-16)
      Urgent action is needed to address mental health issues globally. In Africa, where mental health disorders account for a huge burden of disease and disability, and where in general less than 1% of the already small health ...
    • “Deeper into a hole?” : borrowing and lending in South Africa 

      James, Deborah (University of Chicago Press Journals, 2014-08)
      In South Africa, with upward mobility much aspired to but seldom attained, householders must spend money they have not yet earned. Borrowing both from formal institutions and smaller moneylenders (legal and illegal) positions ...
    • Demonstration and pantomime in the evolution of teaching 

      Gardenfors, Peter (Frontiers Media, 2017)
      Donald proposes that early Homo evolved mimesis as a new form of cognition. This article investigates the mimesis hypothesis in relation to the evolution of teaching. The fundamental capacities that distinguish hominin ...
    • Developmental origins of health and disease in Africa - influencing early life 

      Davies, Justine Ina; Macnab, Andrew John; Byass, Peter; Norris, Shane A.; Nyirenda, Moffat; Singhal, Atul; Sobngwi, Eugene; Daar, Abdallah S. (Elsevier, 2018)
      It is well established that Africa is undergoing rapid transitions resulting in a triple burden of malnutrition, infectious diseases, and non-communicable diseases (NCDs).1,2 That health systems are unlikely to be able to ...
    • Diffusion markers of dendritic density and arborization in gray matter predict differences in intelligence 

      Genc, Erhan; Fraenz, Christoph; Schluter, Caroline; Friedrich, Patrick; Hossiep, Rudiger; Voelkle, Manuel C.; Ling, Josef M.; Gunturkun, Onur; Jung, Rex E. (Nature Research (part of Springer Nature), 2018)
      Previous research has demonstrated that individuals with higher intelligence are more likely to have larger gray matter volume in brain areas predominantly located in parieto-frontal regions. These findings were usually ...
    • Dissecting long-term glucose metabolism identifies new susceptibility period for metabolic dysfunction in aged mice 

      Chauhan, Anuradha; Weiss, Heike; Koch, Franziska; Ibrahim, Saleh M.; Vera, Julio; Wolkenhauer, Olaf; Tiedge, Markus (Public Library of Science, 2015)
      Metabolic disorders, like diabetes and obesity, are pathogenic outcomes of imbalance in glucose metabolism. Nutrient excess and mitochondrial imbalance are implicated in dysfunctional glucose metabolism with age. We used ...
    • Effectiveness of home-based nutritional counselling and support on exclusive breastfeeding in urban poor settings in Nairobi : a cluster randomized controlled trial 

      Kimani-Murage, Elizabeth W.; Griffiths, Paula L.; Wekesah, Frederick Murunga; Wanjohi, Milka; Muhia, Nelson; Muriuki, Peter; Egondi, Thaddaeus; Kyobutungi, Catherine; Ezeh, Alex C.; McGarvey, Stephen T.; Musoke, Rachel N.; Norris, Shane A.; Madise, Nyovani J. (BMC (part of Springer Nature), 2017)
      Background: Exclusive breastfeeding (EBF) improves infant health and survival. We tested the effectiveness of a homebased intervention using Community Health Workers (CHWs) on EBF for six months in urban poor settings in ...
    • Enabling multiscale modeling in systems medicine 

      Wolkenhauer, Olaf; Auffray, Charles; Brass, Olivier; Clairambault, Jean; Deutsch, Andreas; Drasdo, Dirk; Gervasio, Francesco; Preziosi, Luigi; Maini, Philip; Marciniak-Czochra, Anna; Kossow, Christina; Kuepfer, Lars; Rateitschak, Katja; Ramis-Conde, Ignacio; Ribba, Benjamin; Schuppert, Andreas; Smallwood, Rod; Stamatakos, Georgios; Winter, Felix; Byrne, Helen (BioMed Central, 2014-03)
      [See article for abstract].
    • Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries 

      Ocklenburg, Sebastian; Schmitz, Judith; Moinfar, Zahra; Moser, Dirk; Klose, Rena; Lor, Stephanie; Kunz, Georg; Tegenthoff, Martin; Faustmann, Pedro; Francks, Clyde; Epplen, Jorg T.; Kumsta, Robert; Gunturkun, Onur (eLife Sciences Publications, 2017)
      Lateralization is a fundamental principle of nervous system organization but its molecular determinants are mostly unknown. In humans, asymmetric gene expression in the fetal cortex has been suggested as the molecular basis ...
    • Evolution of computational models in BioModels Database and the Physiome Model Repository 

      Scharm, Martin; Gebhardt, Tom; Toure, Vasundra; Bagnacani, Andrea; Salehzadeh-Yazdi, Ali; Wolkenhauer, Olaf; Waltemath, Dagmar (BioMed Central, 2018-04-12)
      ENGLISH SUMMARY : Background: A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and ...
    • Factors influencing the use of supervised delivery services in Garu-Tempane District, Ghana 

      Ganle, John K.; Kombet, Mathew L.; Baatiema, Leonard (BMC (part of Springer Nature), 2019-04-27)
      Background: There is evidence that supervised delivery has the potential to improve birth outcomes for both women and newborns. However, not all women especially in low-income settings like Ghana use supervised delivery ...
    • General criterion for harmonicity 

      Proesmans, Karel; Vandebroek, Hans; Van Den Broeck, Christian (American Physical Society, 2017)
      Inspired by Kubo-Anderson Markov processes, we introduce a new class of transfer matrices whose largest eigenvalue is determined by a simple explicit algebraic equation. Applications include the free energy calculation for ...
    • How spatial scale shapes the generation and management of multiple ecosystem services 

      Lindborg, Regina; Gordon, Line J.; Malinga, Rebecka; Bengtsson, Jan; Peterson, Garry; Bommarco, Riccardo; Deutsch, Lisa; Gren, Asa; Rundlof, Maj; Smith, Henrik G. (Ecological Society of America, 2017)
      The spatial extent of ecological processes has consequences for the generation of ecosystem services related to them. However, management often fails to consider issues of scale when targeting ecological processes underpinning ...
    • Image-based mHealth for remote diagnostic assistance a means to promote equity in quality care 

      Laflamme, Lucie (Taylor & Francis Open, 2017)
      No abstract
    • An integrated approach to processing WHO-2016 verbal autopsy data : the InterVA-5 model 

      Byass, Peter; Hussain-Alkhateeb, Laith; D’Ambruoso, Lucia; Clark, Samuel; Davies, Justine; Fottrell, Edward; Bird, Jon; Kabudula, Chodziwadziwa; Tollman, Stephen; Kahn, Kathleen; Schioler, Linus; Petzold, Max (BMC (part of Springer Nature), 2019-05-30)
      Background: Verbal autopsy is an increasingly important methodology for assigning causes to otherwise uncertified deaths, which amount to around 50% of global mortality and cause much uncertainty for health planning. The ...
    • Lateralization of the avian magnetic compass : analysis of its early plasticity 

      Gehring, Dennis; Gunturkun, Onur; Wiltschko, Wolfgang; Wiltschko, Roswitha (MDPI, 2017)
      In European Robins, Erithacus rubecula, the magnetic compass is lateralized in favor of the right eye/left hemisphere of the brain. This lateralization develops during the first winter and initially shows a great plasticity. ...
    • Mathematical models and the fight against diseases in Africa 

      Getz, W. M.; Gouws, E.; Hahne, F.; Kopp, P. E.; Mostert, P.; Muller, C.; Seioghe, C.; Williams, B.; Witten, G.; Bradshaw, D.; Dorrington, R. (Academy of Science for South Africa, 2003)
      A new initiative proposes to build capacity across Africa to collect data and conduct quantitative analyses necessary to understand the dynamics of major diseases afflicting the continent, with an initial emphasis on HIV/AIDS.
    • Medical mobile technologies – what is needed for a sustainable and scalable implementation on a global scale? 

      Lundin, Johan; Dumont, Guy (Taylor & Francis Open, 2017)
      Current advances within medical technology show great potential from a global health perspective. Inexpensive, effective solutions to common problems within diagnostics, medical procedures and access to medical information ...
    • Observed full blood count and lymphocyte subset values in a cohort of clinically healthy South African children from a semi-informal settlement in Cape Town 

      Lawrie, Denise; Payne, Helen; Nieuwoudt, Martin; Glencross, Deborah Kim (Health & Medical Publishing Group, 2015-09)
      Background. The paediatric full blood count and lymphocyte subset reference intervals used by the National Health Laboratory Service (NHLS), South Africa (SA), are taken from two international reference interval publications. ...