Browsing Stellenbosch Institute for Advanced Studies (STIAS) by Title

Now showing items 1-20 of 30

    • After Fukushima : the precautionary principle revisited 

      Huber, Wolfgang (AOSIS Publishing, 2012-12-06)
      Etienne de Villiers, more than other theologians, elaborates on basic elements of a Christian ethics of responsibility. He distinguishes between retrospective and prospective responsibility. The prospective aspect attracted ...

    • Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice 

      Muller, Sarah; Kaiser, Hannah; Kruger, Burkhard; Fitzner, Brit; Lange, Falko; Bock, Cristin N.; Nizze, Horst; Ibrahim, Saleh M.; Fuellen, Georg; Wolkenhauer, Olaf; Jaster, Robert (PLoS, 2014-04-10)
      Reactive oxygen species (ROS) have been implicated in the pathogenesis of acute pancreatitis (AP) for many years but experimental evidence is still limited. Uncoupling protein 2 (UCP2)-deficient mice are an accepted model ...

    • Annotation-based feature extraction from sets of SBML models 

      Alm, Rebekka; Waltemath, Dagmar; Wolfien, Markus; Wolkenhauer, Olaf; Henkel, Ron (BioMed Central, 2015-04-15)
      Background: Model repositories such as BioModels Database provide computational models of biological systems for the scientific community. These models contain rich semantic annotations that link model entities to concepts ...

    • Anti-inflammatory effects of reactive oxygen species : a multi-valued logical model validated by formal concept analysis 

      Wollbold, Johannes; Jaster, Robert; Muller, Sarah; Rateitschak, Katja; Wolkenhauer, Olaf (BioMed Central, 2014-09)
      Background: Recent findings suggest that in pancreatic acinar cells stimulated with bile acid, a pro-apoptotic effect of reactive oxygen species (ROS) dominates their effect on necrosis and spreading of inflammation. The ...

    • COMODI : an ontology to characterise differences in versions of computational models in biology 

      Scharm, Martin; Waltemath, Dagmar; Mendes, Pedro; Wolkenhauer, Olaf (BioMed Central, 2016-07-11)
      Background: Open model repositories provide ready-to-reuse computational models of biological systems. Models within those repositories evolve over time, leading to different model versions. Taken together, the underlying ...

    • Consumer-resource dynamics : quantity, quality, and allocation 

      Getz, Wayne M.; Owen-Smith, Norman (Public Library of Science, 2011-01-20)
      Background: The dominant paradigm for modeling the complexities of interacting populations and food webs is a system of coupled ordinary differential equations in which the state of each species, population, or functional ...

    • Death domain signaling by disulfide-linked dimers of the p75 neurotrophin receptor mediates neuronal death in the CNS 

      Tanaka, Kazuhiro; Kelly, Claire E.; Goh, Ket Yin; Lim, Kim Buay; Ibanez, Carlos F. (Society for Neuroscience, 2016-05-18)
      The p75 neurotrophin receptor (p75NTR) mediates neuronal death in response to neural insults by activating a caspase apoptotic pathway. The oligomeric state and activation mechanism that enable p75NTR to mediate these ...

    • Declaration on mental health in Africa : moving to implementation 

      Daar, Abdallah S.; Jacobs, Marian; Wall, Stig; Groenewald, Johann; Eaton, Julian; Patel, Vikram; Dos Santos, Palmira; Kagee, Ashraf; Gevers, Anik; Sunkel, Charlene; Andrews, Gail; Daniels, Ingrid; Ndetei, David (Co-Action Publishing, 2014-06-16)
      Urgent action is needed to address mental health issues globally. In Africa, where mental health disorders account for a huge burden of disease and disability, and where in general less than 1% of the already small health ...

    • “Deeper into a hole?” : borrowing and lending in South Africa 

      James, Deborah (University of Chicago Press Journals, 2014-08)
      In South Africa, with upward mobility much aspired to but seldom attained, householders must spend money they have not yet earned. Borrowing both from formal institutions and smaller moneylenders (legal and illegal) positions ...

    • Dissecting long-term glucose metabolism identifies new susceptibility period for metabolic dysfunction in aged mice 

      Chauhan, Anuradha; Weiss, Heike; Koch, Franziska; Ibrahim, Saleh M.; Vera, Julio; Wolkenhauer, Olaf; Tiedge, Markus (Public Library of Science, 2015)
      Metabolic disorders, like diabetes and obesity, are pathogenic outcomes of imbalance in glucose metabolism. Nutrient excess and mitochondrial imbalance are implicated in dysfunctional glucose metabolism with age. We used ...

    • Enabling multiscale modeling in systems medicine 

      Wolkenhauer, Olaf; Auffray, Charles; Brass, Olivier; Clairambault, Jean; Deutsch, Andreas; Drasdo, Dirk; Gervasio, Francesco; Preziosi, Luigi; Maini, Philip; Marciniak-Czochra, Anna; Kossow, Christina; Kuepfer, Lars; Rateitschak, Katja; Ramis-Conde, Ignacio; Ribba, Benjamin; Schuppert, Andreas; Smallwood, Rod; Stamatakos, Georgios; Winter, Felix; Byrne, Helen (BioMed Central, 2014-03)
      [See article for abstract].

    • Evolution of computational models in BioModels Database and the Physiome Model Repository 

      Scharm, Martin; Gebhardt, Tom; Toure, Vasundra; Bagnacani, Andrea; Salehzadeh-Yazdi, Ali; Wolkenhauer, Olaf; Waltemath, Dagmar (BioMed Central, 2018-04-12)
      ENGLISH SUMMARY : Background: A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and ...

    • Graduate School formats and functions 

      Groenewald, Johann; Steenekamp, Cindy (SUN MeDIA, 2016)
      INTRODUCTION: This chapter explores the reasons for the success, in the area of doctoral studies, of the recently established Graduate School in the Faculty of Arts and Social Sciences (FASS) at Stellenbosch University ...

    • Observed full blood count and lymphocyte subset values in a cohort of clinically healthy South African children from a semi-informal settlement in Cape Town 

      Lawrie, Denise; Payne, Helen; Nieuwoudt, Martin; Glencross, Deborah Kim (Health & Medical Publishing Group, 2015-09)
      Background. The paediatric full blood count and lymphocyte subset reference intervals used by the National Health Laboratory Service (NHLS), South Africa (SA), are taken from two international reference interval publications. ...

    • On the modularity of the intrinsic flexibility of the µ opioid receptor : a computational study 

      Fossepre, Mathieu; Leherte, Laurence; Laaksonen, Aatto; Vercauteren, Daniel P. (Public Library of Science, 2015)
      The µ opioid receptor (µOR), the principal target to control pain, belongs to the G protein-coupled receptors (GPCRs) family, one of the most highlighted protein families due to their importance as therapeutic targets. The ...

    • On the physiology of jouissance : interpreting the mesolimbic dopaminergic reward functions from a psychoanalytic perspective 

      Bazan, Ariane; Detandt, Sandrine (Frontiers, 2013-11-06)
      Jouissance is a Lacanian concept, infamous for being impervious to understanding and which expresses the paradoxical satisfaction that a subject may derive from his symptom. On the basis of Freud’s “experience of satisfaction” ...

    • Overcoming violence - a basic task of Christian churches 

      Huber, Wolfgang (AOSIS Publishing, 2011-12-12)
      In this article – based on the second of two keynote lectures at a conference on violence – the view is developed that the task of the church with respect to violence consists mainly in overcoming violence. In the first ...

    • Parameter identifiability and sensitivity analysis predict targets for enhancement of STAT1 activity in pancreatic cancer and stellate cells 

      Rateitschak, Katja; Winter, Felix; Lange, Falko; Jaster, Robert; Wolkenhauer, Olaf (Public Library of Science, 2012-12)
      The present work exemplifies how parameter identifiability analysis can be used to gain insights into differences in experimental systems and how uncertainty in parameter estimates can be handled. The case study, presented ...

    • Progress in human embryonic stem cell research in the United States between 2001 and 2010 

      Vakili, Keyvan; McGahan, Anita M.; Rezaie, Rahim; Mitchell, Will; Daar, Abdallah S. (Public Library of Science, 2015)
      On August 9th, 2001, the federal government of the United States announced a policy restricting federal funds available for research on human embryonic stem cell (hESCs) out of concern for the “vast ethical mine fields” ...

    • Religion and violence in a globalised world 

      Wolfgang, Huber (AOSIS Publishing, 2011-11-18)
      Violent religious extremism is seen as one of the mega-problems of the 21st century. This article – based on a key lecture at the conference on ‘Violence in a democratic South Africa’ at the University of Pretoria and ...