Treatment of Heterogeneous Emphysema Using the Spiration IBV Valves

Date
2009
Authors
Springmeyer S.C.
Bolliger C.T.
Waddell T.K.
Gonzalez X.
Wood D.E.
Journal Title
Journal ISSN
Volume Title
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Abstract
Ninety-eight emphysema patients were treated at 13 international sites during a 3-year series of single-arm, open-label studies with the IBV valve and a multi-lobar treatment approach. Fifty six percent of subjects had a clinically meaningful improvement in health-related quality of life, but standard pulmonary function and exercise studies were insensitive effectiveness measures. Quantitative CT analyses of regional lung changes showed lobar volume changes in over 85% of subjects. Lung volume reduction was an uncommon mechanism for a treatment response with bilateral upper lobe treatment. A redirection of inspired air, an interlobar shift to healthier lung tissue, was the most common mechanism for a valve treatment response. © 2009 Elsevier Inc. All rights reserved.
Description
Keywords
adult, aged, atelectasis, bronchospasm, clinical effectiveness, clinical trial, cohort analysis, computer assisted tomography, controlled study, emphysema, exercise, female, heart arrest, heart infarction, heterogeneous emphysema, hospitalization, human, inspiratory capacity, lung function, lung lobe, lung parenchyma, lung resection, lung volume, major clinical study, male, multicenter study, open study, pneumothorax, priority journal, prosthesis, quality of life, quantitative analysis, respiratory distress, review, spiration IBV valve, surgical approach, thorax pain, treatment outcome, treatment response, Aged, Bronchoscopy, Cohort Studies, Equipment Design, Exercise Tolerance, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Pneumonectomy, Pulmonary Emphysema, Retrospective Studies, Treatment Outcome
Citation
Thoracic Surgery Clinics
19
2