Effects of DSP-4 on monoamine and monoamine metabolite levels and on beta adrenoceptor binding kinetics in rat brain at different times after administration
Date
1993, 1993
Authors
Theron C.N.
De Villiers A.S.
Taljaard J.J.F.
Theron C.N.
De Villiers A.S.
Taljaard J.J.F.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Effects of DSP-4 on noradrenaline (NA), 3-methoxy-4-hydroxyphenyl glycol (MHPG), serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels and on beta adrenoceptor binding kinetic (Bmax and K(D)) in rat hippocampus, cortex and hypothalamus were studied between 24 hours and 14 days after systemic administration. Beta adrenoceptor numbers in hippocampus and cortex, but not in hypothalamus, were significantly increased after DSP-4. No significant changes in K(D) value were observed in hypothalamus, but significant increases in this parameter were measured in hippocampus and cortex. NA and MHPG levels were significantly decreased in all three brain regions, but MHPG/NA ratios were increased in hippocampus, decreased in cortex and unchange in hypothalamus. Very prominent increases in 5-HIAA levels were observed in all three brain regions, but only at one day after DSP-4. The greatest increases in 5-HIAA levels occurred in the hippocampus, but this effect of DPS-4 appeared to be slightly diminished by pre-treatment with fluoxetine. In cortex and hippocampus 5-HT levels were slightly, but significantly decreased after DSP-4.
Effects of DSP-4 on noradrenaline (NA), 3-methoxy-4-hydroxyphenyl glycol (MHPG), serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels and on beta adrenoceptor binding kinetic (Bmax and K(D)) in rat hippocampus, cortex and hypothalamus were studied between 24 hours and 14 days after systemic administration. Beta adrenoceptor numbers in hippocampus and cortex, but not in hypothalamus, were significantly increased after DSP-4. No significant changes in K(D) value were observed in hypothalamus, but significant increases in this parameter were measured in hippocampus and cortex. NA and MHPG levels were significantly decreased in all three brain regions, but MHPG/NA ratios were increased in hippocampus, decreased in cortex and unchange in hypothalamus. Very prominent increases in 5-HIAA levels were observed in all three brain regions, but only at one day after DSP-4. The greatest increases in 5-HIAA levels occurred in the hippocampus, but this effect of DPS-4 appeared to be slightly diminished by pre-treatment with fluoxetine. In cortex and hippocampus 5-HT levels were slightly, but significantly decreased after DSP-4.
Effects of DSP-4 on noradrenaline (NA), 3-methoxy-4-hydroxyphenyl glycol (MHPG), serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels and on beta adrenoceptor binding kinetic (Bmax and K(D)) in rat hippocampus, cortex and hypothalamus were studied between 24 hours and 14 days after systemic administration. Beta adrenoceptor numbers in hippocampus and cortex, but not in hypothalamus, were significantly increased after DSP-4. No significant changes in K(D) value were observed in hypothalamus, but significant increases in this parameter were measured in hippocampus and cortex. NA and MHPG levels were significantly decreased in all three brain regions, but MHPG/NA ratios were increased in hippocampus, decreased in cortex and unchange in hypothalamus. Very prominent increases in 5-HIAA levels were observed in all three brain regions, but only at one day after DSP-4. The greatest increases in 5-HIAA levels occurred in the hippocampus, but this effect of DPS-4 appeared to be slightly diminished by pre-treatment with fluoxetine. In cortex and hippocampus 5-HT levels were slightly, but significantly decreased after DSP-4.
Description
Keywords
beta adrenergic receptor; monoamine; noradrenalin; serotonin; animal experiment; animal tissue; article; binding kinetics; brain cortex; hippocampus; hypothalamus; male; neurochemistry; nonhuman; priority journal; rat; receptor binding; Animal; Benzylamines; Biogenic Monoamines; Brain; Cerebral Cortex; Hippocampus; Hydroxyindoleacetic Acid; Hypothalamus; Kinetics; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Serotonin; Support, Non-U.S. Gov't; Animalia, beta adrenergic receptor, monoamine, noradrenalin, serotonin, animal experiment, animal tissue, article, binding kinetics, brain cortex, hippocampus, hypothalamus, male, neurochemistry, nonhuman, priority journal, rat, receptor binding, Animal, Benzylamines, Biogenic Monoamines, Brain, Cerebral Cortex, Hippocampus, Hydroxyindoleacetic Acid, Hypothalamus, Kinetics, Male, Methoxyhydroxyphenylglycol, Norepinephrine, Rats, Rats, Wistar, Receptors, Adrenergic, beta, Serotonin, Support, Non-U.S. Gov't, Animalia
Citation
Neurochemical Research
18
12
Neurochemical Research
18
12
18
12
Neurochemical Research
18
12