Decreased hippocampal noradrenaline does not affect corticosterone release following electrical stimulation of CA1 pyramidal cells
Date
1994, 1994
Authors
Daniels W.M.U.
Jaffer A.
Russell V.A.
Taljaard J.J.F.
Daniels W.M.U.
Jaffer A.
Russell V.A.
Taljaard J.J.F.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Bipolar electrodes were implanted into the CA1 pyramidal cells of the dorsal hippocampus and the effect of electrical stimulation of these cells on corticosterone secretion was investigated in freely moving rats. Histology showed that the electrodes were positioned in close proximity to the CA1 pyramidal cells. Rats that were subjected to high intensity electrical stimulation (1, 10, and 100μA) behaved differently when compared to their sham stimulated controls. They were more active and displayed wet dog shakes. Plasma corticosterone levels increased dose- dependently in rats subjected to different electrical stimulation intensities. Although prior treatment (24 hours) of rats with DSP4 (60 mg/kg, i.p.) significantly reduced hippocampal noradrenaline content by 46%, it did not bring about any behavioural changes. DSP4 treatment also had no effect on electrically stimulated corticosterone release. These data suggested that stimulation of CA1 pyramidal cells may lead to increased corticosterone release and that a decrease in hippocampal noradrenaline concentration was unable to alter this corticosterone response.
Bipolar electrodes were implanted into the CA1 pyramidal cells of the dorsal hippocampus and the effect of electrical stimulation of these cells on corticosterone secretion was investigated in freely moving rats. Histology showed that the electrodes were positioned in close proximity to the CA1 pyramidal cells. Rats that were subjected to high intensity electrical stimulation (1, 10, and 100μA) behaved differently when compared to their sham stimulated controls. They were more active and displayed wet dog shakes. Plasma corticosterone levels increased dose- dependently in rats subjected to different electrical stimulation intensities. Although prior treatment (24 hours) of rats with DSP4 (60 mg/kg, i.p.) significantly reduced hippocampal noradrenaline content by 46%, it did not bring about any behavioural changes. DSP4 treatment also had no effect on electrically stimulated corticosterone release. These data suggested that stimulation of CA1 pyramidal cells may lead to increased corticosterone release and that a decrease in hippocampal noradrenaline concentration was unable to alter this corticosterone response.
Bipolar electrodes were implanted into the CA1 pyramidal cells of the dorsal hippocampus and the effect of electrical stimulation of these cells on corticosterone secretion was investigated in freely moving rats. Histology showed that the electrodes were positioned in close proximity to the CA1 pyramidal cells. Rats that were subjected to high intensity electrical stimulation (1, 10, and 100μA) behaved differently when compared to their sham stimulated controls. They were more active and displayed wet dog shakes. Plasma corticosterone levels increased dose- dependently in rats subjected to different electrical stimulation intensities. Although prior treatment (24 hours) of rats with DSP4 (60 mg/kg, i.p.) significantly reduced hippocampal noradrenaline content by 46%, it did not bring about any behavioural changes. DSP4 treatment also had no effect on electrically stimulated corticosterone release. These data suggested that stimulation of CA1 pyramidal cells may lead to increased corticosterone release and that a decrease in hippocampal noradrenaline concentration was unable to alter this corticosterone response.
Description
Keywords
corticosterone; neurotransmitter; noradrenalin; animal experiment; animal tissue; article; controlled study; corticosterone release; dose response; electrostimulation; high performance liquid chromatography; hippocampus; male; nonhuman; priority journal; pyramidal nerve cell; radioimmunoassay; rat; Animal; Corticosterone; Electric Stimulation; Hippocampus; Male; Norepinephrine; Rats; Rats, Wistar; Support, Non-U.S. Gov't; Animalia; Canis familiaris, corticosterone, neurotransmitter, noradrenalin, animal experiment, animal tissue, article, controlled study, corticosterone release, dose response, electrostimulation, high performance liquid chromatography, hippocampus, male, nonhuman, priority journal, pyramidal nerve cell, radioimmunoassay, rat, Animal, Corticosterone, Electric Stimulation, Hippocampus, Male, Norepinephrine, Rats, Rats, Wistar, Support, Non-U.S. Gov't, Animalia, Canis familiaris
Citation
Neurochemical Research
19
12
Neurochemical Research
19
12
19
12
Neurochemical Research
19
12