Brachial amyotrophic diplegia (segmental proximal spinal muscular atrophy) associated with HIV infection
Date
2008
Authors
Henning F.
Hewlett R.H.
Journal Title
Journal ISSN
Volume Title
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Abstract
Several forms of motor neuron disease occurring in association with HIV infection have been described. Segmental proximal spinal muscular atrophy or brachial amyotrophic diplegia, a rare segmental variant of motor neuron disease with isolated bilateral upper extremity weakness, has previously been described in a single case report. We describe a patient who is HIV-seropositive presenting with this phenotype and illustrate novel findings on MRI of the cervical cord, consisting of focal atrophy and T2 hyperintense signal change involving the anterior grey matter. Additionally, a number of differences compared with patients without HIV presenting with this motor neuron disease variant are highlighted.
Description
Keywords
antiretrovirus agent, adult, article, brachial myotrophic diplegia, case report, cervical spinal cord, clinical feature, gray matter, highly active antiretroviral therapy, human, Human immunodeficiency virus 1, Human immunodeficiency virus 1 infection, male, neuroimaging, neurologic examination, nuclear magnetic resonance imaging, phenotype, priority journal, spinal muscular atrophy, Acquired Immunodeficiency Syndrome, Adult, Antiretroviral Therapy, Highly Active, Brain, HIV Infections, Humans, Magnetic Resonance Imaging, Male, Motor Neuron Disease, Muscular Atrophy, Spinal, Phenotype, Vitamin B 12 Deficiency
Citation
Journal of Neurology, Neurosurgery and Psychiatry
79
12
79
12