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Now showing items 1-8 of 8

    • Determining ancestry proportions in complex admixture scenarios in South Africa using a novel proxy ancestry selection method 

      Chimusa, Emile R.; Daya, Michelle; Möller, Marlo; Ramesar, Raj; Henn, Brenna M.; Van Helden, Paul D.; Mulder, Nicola J.; Hoal, Eileen G. (PLoS, 2013-09)
      Admixed populations can make an important contribution to the discovery of disease susceptibility genes if the parental populations exhibit substantial variation in susceptibility. Admixture mapping has been used successfully, ...

    • Exome capture from saliva produces high quality genomic and metagenomic data 

      Kidd, Jeffrey M.; Sharpton, Thomas J.; Bobo, Dean; Norman, Paul J.; Martin, Alicia R.; Carpenter, Meredith L.; Sikora, Martin; Gignoux, Christopher R.; Nemat-Gorgani, Neda; Adams, Alexandra; Guadalupe, Moraima; Guo, Xiaosen; Feng, Qiang; Li, Yingrui; Liu, Xiao; Parham, Peter; Hoal, Eileen G.; Feldman, Marcus W.; Pollard, Katherine S.; Wall, Jeffrey D.; Bustamante, Carlos D.; Henn, Brenna M. (BioMed Central, 2014-04)
      Background Targeted capture of genomic regions reduces sequencing cost while generating higher coverage by allowing biomedical researchers to focus on specific loci of interest, such as exons. Targeted capture also ...

    • Gene polymorphisms in African buffalo sssociated with susceptibility to Bovine tuberculosis infection 

      Le Roex, Nikki; Koets, Ad P.; Van Helden, Paul D.; Hoal, Eileen G. (Public Library of Science -- PLoS, 2013-05)
      Bovine tuberculosis (BTB) is a chronic, highly infectious disease that affects humans, cattle and numerous species of wildlife. In developing countries such as South Africa, the existence of extensive wildlife-human-livestock ...

    • Investigating the role of gene-gene interactions in TB susceptibility 

      Daya, Michelle; Van der Merwe, Lize; Van Helden, Paul D.; Moller, Marlo; Hoal, Eileen G. (Public Library of Science, 2015-04)
      Tuberculosis (TB) is the second leading cause of mortality from infectious disease worldwide. One of the factors involved in developing disease is the genetics of the host, yet the field of TB susceptibility genetics has ...

    • Novel SNP discovery in African buffalo, Syncerus caffer, using high-throughput sequencing 

      Le Roex, Nikki; Noyes, Harry; Brass, Andrew; Bradley, Daniel G.; Kemp, Steven J.; Kay, Suzanne; Van Helden, Paul D.; Hoal, Eileen G. (PLoS, 2012-11-07)
      The African buffalo, Syncerus caffer, is one of the most abundant and ecologically important species of megafauna in the savannah ecosystem. It is an important prey species, as well as a host for a vast array of nematodes, ...

    • A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility 

      Uren, Caitlin; Henn, Brenna M.; Franke, Andre; Wittig, Michael; van Helden, Paul D.; Hoal, Eileen G.; Moller, Marlo (Public Library of Science, 2017)
      Utilizing data from published tuberculosis (TB) genome-wide association studies (GWAS), we use a bioinformatics pipeline to detect all polymorphisms in linkage disequilibrium (LD) with variants previously implicated in ...

    • Promoter variation in the DC-SIGN–Encoding Gene CD209 is associated with tuberculosis 

      Barreiro, Luis B.; Neyrolles, Olivier; Babb, Chantal L.; Tailleux, Ludovic; Quach, Helene; McElreavey, Ken; Van Helden, Paul D.; Hoal, Eileen G.; Gicquel, Brigitte; Quintana-Murci, Lluis (Public Library of Science (PLOS), 2006-01)
      Background Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis receptor on human ...

    • Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population 

      Daya, Michelle; Van der Merwe, Lize; Gignoux, Christopher R.; Van Helden, Paul D.; Moller, Marlo; Hoal, Eileen G. (BioMed Central, 2014-11)
      Background: The admixed South African Coloured population is ideally suited to the discovery of tuberculosis susceptibility genetic variants and their probable ethnic origins, but previous attempts at finding such variants ...