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Functional and genetic study of M. tuberculosis glutamine synthetase (GS) and other factors possibly involved in GS metabolism

Hayward, Don (Stellenbosch : Stellenbosch University, 2007-12)

ENGLISH ABSTRACT: Sequence analysis showed that the essential glnA1 gene of Mycobacterium tuberculosis might be closely related to an actinomycetes progenitor sequence and that this sequence may have undergone duplication ...
Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis

Harper, Catriona J Hayward, Don Kidd, Martin Wiid, Ian Van Helden, Paul (BioMed Central, 2010-05)

Background: The assimilation of nitrogen is an essential process in all prokaryotes, yet a relatively limited amount of information is available on nitrogen metabolism in the mycobacteria. The physiological role and ...
Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation

Hayward, Don Van Helden, Paul D. Wiid, Ian J. F. (BioMed Central, 2009-02)

Background: Although the gene encoding for glutamine synthetase (glnA) is essential in several organisms, multiple glnA copies have been identified in bacterial genomes such as those of the phylum Actinobacteria, notably ...