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Now showing items 1-4 of 4

    • Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis 

      Barnard, Marinus (Stellenbosch : Stellenbosch University, 2013-03)
      ENGLISH ABSTRACT: The epidemic levels of drug-resistant tuberculosis (DR-TB) in high-burden countries such as South Africa, which is currently ranked as third highest in the world, is the result of a synergistic relationship ...

    • Rapid sequencing of the mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility 

      Streicher, Elizabeth M.; Maharaj, Kashmeel; York, Talita; Van Heerden, Carel; Barnard, Marinus; Diacon, Andreas; Mendel, Carl M.; Bosman, Marlein E.; Hepple, Juli A.; Pym, Alexander S.; Warren, Robin M.; van Helden, Paul D. (American Society for Microbiology, 2014)
      We developed a pyrazinamidase gene DNA-sequencing method to rapidly identify pyrazinamide resistance-causing mutations in GenoLyse-treated, smear-positive sputum specimens. The sensitivity and specificity were 90.9 and ...

    • Risk factors associated with isoniazid resistance in tuberculosis 

      Barnard, Marinus (Stellenbosch : University of Stellenbosch, 2005-12)
      Tuberculosis (TB) is one of the most serious infectious diseases known to mankind, with devastating outcomes in the poorest countries in the world. Isoniazid is the cornerstone of all first-line anti-TB regimens. Forty-eight ...

    • The use of digital PCR to improve the application of quantitative molecular diagnostic methods for tuberculosis 

      Devonshire, Alison S.; O’Sullivan, Denise M.; Honeyborne, Isobella; Jones, Gerwyn; Karczmarczyk, Maria; Pavsic, Jernej; Gutteridge, Alice; Milavec, Mojca; Mendoza, Pablo; Schimmel, Heinz; Van Heuverswyn, Fran; Gorton, Rebecca; Cirillo, Daniela Maria; Borroni, Emanuele; Harris, Kathryn; Barnard, Marinus; Heydenrych, Anthenette; Ndusilo, Norah; Wallis, Carole L.; Pillay, Keshree; Barry, Thomas; Reddington, Kate; Richter, Elvira; Mozioglu, Erkan; Akyurek, Sema; Yalcınkaya, Burhanettin; Akgoz, Muslum; Zel, Jana; Foy, Carole A.; McHugh, Timothy D.; Huggett, Jim F. (BioMed Central, 2016)
      Background: Real-time PCR (qPCR) based methods, such as the Xpert MTB/RIF, are increasingly being used to diagnose tuberculosis (TB). While qualitative methods are adequate for diagnosis, the therapeutic monitoring of TB ...