Subject
Now showing items 1-16 of 16
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The development of a novel fluorescentmarker phage technology system for the early diagnosis of tuberculosis disease
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), is a major cause for mortality and morbidity world-wide with a death toll only second to HIV among infectious diseases. Drug ... -
Diagnostic utility of the line probe assay for the detection of drug resistance in Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: The epidemic levels of drug-resistant tuberculosis (DR-TB) in high-burden countries such as South Africa, which is currently ranked as third highest in the world, is the result of a synergistic relationship ... -
Elucidation of the mode of action of a furanone based antituberculosis compound
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: The prevalence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis has been increasing to alarming levels globally. This has been exacerbated by tuberculosis ... -
Evaluation of multiple cytokine levels to improve our understanding of protective immune responses against Tuberculosis and to develop novel diagnostic methods
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Important steps towards the global control of Tuberculosis include the improvement of diagnosis, the development of effective vaccines and the identification of correlates of protection/protective immunity ... -
The evolution of the Mycobacterium tuberculosis proteome in response to the development of drug resistance
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: This study is the first of its kind to highlight the importance of using the latest state of the art technology available in the field of proteomics as a complementary tool to characterize the proteome ... -
Gene expression and cytokine pattern of pulmonary tuberculosis patients and their contacts in Ethiopia
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: The immune response against M. tuberculosis is multifactorial, involving a network of innate and adaptive immune responses. Characterization of the immune response, a clear understanding of the dynamics ... -
Identification of mechanisms regulating the intra cellular concentration of rifampicin in Mycobacterium Tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Rifampicin resistance in clinical isolates of Mycobacterium tuberculosis develops through selection of bacterial variants harbouring mutations in the rpoB gene. These mutations infer a fitness-cost in the ... -
Identification of novel sarcomeric modifiers of hypertrophy in hypertrophic cardiomyopathy using the yeast two-hybrid system
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Left ventricular hypertrophy (LVH) occurs when the cardiomyocytes in the left ventricle become enlarged by increasing in mass in response to haemodynamic pressure overload. This can either be attributed ... -
Improving methods for genotypic drug resistance testing in Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: An important next step to Tuberculosis control relies on the translation of basic science and modern diagnostic techniques into primary health care clinics. These assays must be rapid, inexpensive, ... -
Investigating ligands of cardiac Myosin-Binding Protein C (cMyBPC) as potential regulators of contractility and modifiers of hypertrophy.
(Stellenbosch : Stellenbosch University, 2011-12)ENGLISH ABSTRACT: The regulation of cardiac contractility is dependent on cooperative interaction between the thick and thin filaments, as well as their accessory proteins, within the cardiac sarcomere. Alteration in cardiac ... -
Investigating the Human-M. tuberculosis interactome to identify the host targets of ESAT-6 and other mycobacterial antigens
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: The causative agent of human tuberculosis, Mycobacterium tuberculosis, is an intracellular pathogen that secretes virulence factors, namely ESAT-6 and CFP-10, as substrates of the ESX-1 secretion system. ... -
Investigation into genotypic diagnostics for mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2010-12)ENGLISH ABSTRACT: Diagnostic delay is regarded as a major contributor to the continuous rise in tuberculosis (TB) cases and the emergence and transmission of multidrug-resistant tuberculosis (MDR-TB) and extensively drug ... -
Molecular characterization of drug resistant Mycobacterium tuberculosis isolates from different regions in South Africa
(Stellenbosch : Stellenbosch University, 2012-07-10)ENGLISH ABSTRACT: Application of molecular fingerprinting highlights transmission as the driving force behind the drug resistant epidemic in South Africa. Different strains dominate within different geographical regions, ... -
Pharmacogenetics of Arylamine N-acetyltransferase genes in South African populations
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: Tuberculosis (TB) has been declared a global health emergency by the World Health Organisation, and consequently there is an urgency to develop improved methods of diagnosis and treatment. Despite the ... -
Regulation of efflux in rifampicin resistant mutants of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Multidrug resistant tuberculosis (MDR-TB), defined as having resistance to at least the first-line drugs, isoniazid and rifampicin (RIF), is a global health problem. Mutations in the rpoB gene, encoding ... -
Understanding the evolution and function of the mycobacterial Type VII ESX secretion systems (T7SSs) and their substrates
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis disease, contains five copies of the ESAT-6 gene cluster, each encoding a dedicated ESX protein secretion system which has been defined as ...
