Subject
Now showing items 1-8 of 8
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Differential expression of genes in clinical strains of mycobacterium tuberculosis in response to isoniazid
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: Isoniazid forms part of the first line anti-tuberculosis therapy and it is generally used to treat latent Mycobacterium tuberculosis infection. Isoniazid inhibits synthesis of long chain mycolic acids ... -
Gene expression and cytokine pattern of pulmonary tuberculosis patients and their contacts in Ethiopia
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: The immune response against M. tuberculosis is multifactorial, involving a network of innate and adaptive immune responses. Characterization of the immune response, a clear understanding of the dynamics ... -
Improving methods for genotypic drug resistance testing in Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: An important next step to Tuberculosis control relies on the translation of basic science and modern diagnostic techniques into primary health care clinics. These assays must be rapid, inexpensive, ... -
Investigating the Human-M. tuberculosis interactome to identify the host targets of ESAT-6 and other mycobacterial antigens
(Stellenbosch : Stellenbosch University, 2012-12)ENGLISH ABSTRACT: The causative agent of human tuberculosis, Mycobacterium tuberculosis, is an intracellular pathogen that secretes virulence factors, namely ESAT-6 and CFP-10, as substrates of the ESX-1 secretion system. ... -
Investigation into genotypic diagnostics for mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2010-12)ENGLISH ABSTRACT: Diagnostic delay is regarded as a major contributor to the continuous rise in tuberculosis (TB) cases and the emergence and transmission of multidrug-resistant tuberculosis (MDR-TB) and extensively drug ... -
Investigation of the genetic aetiology of aminoglycoside-induced hearing loss in South African populations
(Stellenbosch : University of Stellenbosch, 2009-12)ENGLISH ABSTRACT: South Africa is currently facing a major multidrug-resistant tuberculosis (MDR-TB) epidemic and has one of the highest incidences in the world. Aminoglycoside antibiotics are commonly used in this country ... -
Long QT syndrome : the identification and verification of putative KCNE2-interacting proteins
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Long QT syndrome (LQTS) is a cardiac repolarization disorder affecting every 1:2000-1:3000 individuals. This disease is characterized by a prolonged QT interval on the surface electrocardiogram (ECG) of ... -
A molecular investigation of a mixed ancestry family displaying dementia and movement disorders
(Stellenbosch : Stellenbosch University, 2008-12)A South African family of Mixed Ancestry presented with a rapidly progressive dementia and a movement disorder which affected a number of individuals across three generations. The initial symptoms included personality ...
