Assessment of the α/ß ratios for arteriovenous malformations, meningiomas, acoustic neuromas, and the optic chiasma
Date
2010
Authors
Vernimmen F.J.A.I.
Slabbert J.P.
Journal Title
Journal ISSN
Volume Title
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Abstract
Purpose: To determine alpha/beta (α/ß) values of arteriovenous malformations (AVM), meningiomas, acoustic neuromas (AN), and the optic chiasma using clinical data. Methods and materials:Data of dose/fractionation schedules form the literature, iso-effective for a specific clinical outcome, were analysed using the Fraction Equivalent plot (FE) method and the Tucker method. Established safe dose/fractionation schedules for the optic chiasma were used to determine its α/ß value. Results:With the FE plot method, an alpha/beta value of 3.76 Gray (Gy) (95 confidence level [CL]: 2.84.6 Gy) for meningiomas, 2.4 Gy (95 CL: 0.83.9 Gy) for acoustic neuroma, and 14.7 Gy (95 CL: 3.825.7 Gy) for arteriovenous malformations were determined. The respective alpha/beta values using the Tucker method were 3.3 Gy (95CL: 2.26.8 Gy), 1.77 Gy (95CL: 1.33.0 Gy) and-57 Gy (95CL:-79.6 to 35.2 Gy). No meaningful α/ß values could be determined for the optic chiasma. Conclusion:Acoustic neuromas with a low α/ß value would show no lesion intrinsic benefit from fractionation. Meningiomas probably benefit from a hypofractionated schedule. The high α/ß value for AVM can be explained but needs further research. Fractionation versus radiosurgery can be considered when the primary objective is to avoid normal tissue damage. © 2010 Informa UK Ltd.
Description
Keywords
acoustic neurinoma, arteriovenous malformation, article, controlled study, human, meningioma, optic chiasm, outcome assessment, priority journal, radiation dose fractionation, radiation response, radiation safety, radiosurgery, treatment response, meta analysis, neuroma, radiation exposure, Arteriovenous Malformations, Dose Fractionation, Humans, Meningeal Neoplasms, Meningioma, Neuroma, Acoustic, Optic Chiasm
Citation
International Journal of Radiation Biology
86
6
86
6