Comparison of the lytic effects of four prostaglandin analogues in the chacma baboon (Papio ursinus ursinus)
Date
1979
Authors
Rall H.J.S.
Zuurmond T.J.
Weidemann A.
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Abstract
Six healthy, cycling female chacma baboons (Papio ursinus ursinus) were used to determine the luteolytic effects of four prostaglandin analogues. The compounds were administered according to a study design which made provision for adequate controls. Five to seven days following ovulation, venous blood was collected and the baboon given a single intramuscular injection of a compound at a recommended dose. Blood was then collected serially every 3 hr for three samples and again at 24, 48, and 72 hr to determine the continued effect of the prostaglandin analogues on corpus luteum production of progesterone. It was found that PGF(2α)-1,15-lactone, 11α(15S)-17-phenyl-18,19,20-trinor-ent-PGE2 methyl ester and 17-phenyl-18,19,20-trinor-PGF(2α) exhibited definite luteolytic potential in this species. Equivocal results were obtained with (15S)-15-methyl-PGF(2α) THAM and its toxic qualities resulted in the demise of three animals.
Description
Keywords
carboprost trometamol, placebo, progesterone, prostaglandin derivative, prostaglandin receptor, u32921e, u35687, u43728, u47473, unclassified drug, 17 phenyl 18,19,20 trinorprostaglandin e2 methyl ester, 17 phenyl 18,19,20 trinorprostaglandin f2 alpha, animal experiment, baboon, drug comparison, female genital system, intramuscular drug administration, luteolysis, monkey, prostaglandin f2 alpha lactone, Animal, Comparative Study, Drug Evaluation, Preclinical, Female, Haplorhini, Injections, Intramuscular, Luteolytic Agents, Papio, Progesterone, Prostaglandins E, Synthetic, Prostaglandins F, Synthetic
Citation
International Journal of Fertility
24
1
24
1