Deletion mapping of 39 random isolated Y-chromosome DNA fragments

Oosthuizen C.J.J. ; Herbert J.S. ; Vermaak L.K. ; Brusnicky J. ; Fricke J. ; Du Plessis L. ; Retief A.E. (1990)


Thirty-nine recombinants isolated from a Y chromosome-specific library were deletion mapped. Seven deletion intervals were defined by hybridization of probes to DNA of eight individuals with aberrant Y chromosomes. Extreme cytogenetic limits of the deletion intervals were determined by in situ hybridization of one probe per deletion interval. Five intervals, with a total of twenty-five probes, were allocated to the long-arm euchromatic region. The probes described will be useful for characterization of aberrant Y chromosomes, in searching for expressed sequences on the Y chromosome, and for further study of the evolutionary relationship between the Y chromosome and other chromosomes.

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