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Bone involvement in childhood acute lymphoblastic leukaemia

dc.contributor.authorWessels G.
dc.contributor.authorHesseling P.B.
dc.contributor.authorVan Der Merwe H.P.D.
dc.date.accessioned2011-05-15T16:16:16Z
dc.date.available2011-05-15T16:16:16Z
dc.date.issued1996
dc.identifier.citationEast African Medical Journal
dc.identifier.citation73
dc.identifier.citation2
dc.identifier.issn0012835X
dc.identifier.urihttp://hdl.handle.net/10019.1/13707
dc.description.abstractThis retrospective study evaluated the prognostic significance of the radiological signs of bony involvement in children with acute lymphoblastic leukaemia (ALL). The skeletal surveys of 52 children with ALL were reviewed for evidence of leukaemic involvement. Radiolucent metaphyseal bands, osteolytic lesions and periosteal reaction were considered signs of leukaemic changes. Twenty eight children had evidence of skeletal involvement of whom 14 had changes at three or more areas. Known risk factors such as age < 2 years and > 10 years, mediastinal lymphadenopathy, splenoømegaly ≥ 5cm below the costal margin, a white cell count of ≥ 20×109/1 and leukaemic blast cells in the cerebrospinal fluid at diagnosis occurred with equal frequency in children with and without skeletal changes as well as those children with signs of Involvement at ≥ 3 sites. Event free survival (Kaplan Meier analysis) also did not differ in these three categories of children. We concluded that bone involvement in childhood ALL is not associated with other risk factors and does not predict outcome per se.
dc.subjectacute lymphocytic leukemia
dc.subjectarticle
dc.subjectbone tumor
dc.subjectchild
dc.subjectdisease free survival
dc.subjecthuman
dc.subjectmetastasis
dc.subjectprediction and forecasting
dc.subjectpreschool child
dc.subjectprognosis
dc.subjectradiography
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectBone Neoplasms
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDisease-Free Survival
dc.subjectHumans
dc.subjectLeukemia, Lymphocytic, Acute, L1
dc.subjectPredictive Value of Tests
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.titleBone involvement in childhood acute lymphoblastic leukaemia
dc.typeArticle
dc.description.versionArticle


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