• 2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion 

  Leisching, G.; Ali, A.; Cole, V.; Baker, B. (Elsevier, 2019-12)

  Host cytoplasmic surveillance pathways are known to elicit type I interferon (IFN) responses which are crucial to antimicrobial defense mechanisms. Oligoadenylate synthetase-like (OASL) protein has been extensively ...
• Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients 

  Lubbers, Rosalie; Sutherland, Jayne S.; Goletti, Delia; De Paus, Roelof A.; Dijkstra, Douwe J.; Van Moorsel, Coline H. M.; Veltkamp, Marcel; Vestjens, Stefan M. T.; Bos, Willem J. W.; Petrone, Linda; Malherbe, Stephanus T.; Walzl, Gerhard; Gelderman, Kyra A.; Groeneveld, Geert H.; Geluk, Annemieke; Ottenhoff, Tom H. M.; Joosten, Simone A.; Trouw, Leendert A. (Elsevier, 2020-03-13)

  Background To facilitate better discrimination between patients with active tuberculosis (TB) and latent TB infection (LTBI), whole blood transcriptomic studies have been performed to identify novel candidate host biomarkers. ...
• Sex as a spectrum : inclusive anatomical education and the translation thereof into clinical practice 

  Lochner, Ruan Dawid. (2022-11)

  ENGLISH ABSTRACT: Introduction: Transgender and non-binary individuals repeatedly experience erasure of their identity in healthcare, ultimately leading to avoidance of healthcare environments, and unsupervised, self ...
• CRISPR interference screening model organisms for TB drugs development. 

  Masikantsi, Nenekazi (Stellenbosch : Stellenbosch University, 2022-11)

  ENGLISH ABSTRACT: Tuberculosis remains a global health burden despite the impetus in drug development mainly due to increasing Mycobacterium tuberculosis (M. tb) resistance against the available treatment regimens. ...
• Overexpression of mmpS5/mmpL5 in Mycobacterium tuberculosis reduces susceptibility to anti-tuberculosis drugs 

  Scott, Leere Ann (Stellenbosch : Stellenbosch University, 2022-12)

  ENGLISH ABSTRACT: Background: Bedaquiline (BDQ) is the first anti-tuberculosis (anti-TB) drug in recent years with a novel mode of action recommended for the treatment of multi-drug resistant-TB. Rv0678 is the most ...
• The role of the intestinal immune system in the development and treatment of type 2 diabetes 

  Parker, Kauthar (Stellenbosch : Stellenbosch University, 2022-11)

  ENGLISH ABSTRACT: Background: Type 2 diabetes (T2D) is largely correlated with obesity. Low-grade systemic inflammation and altered immune homeostasis in the gut are implicated in the pathogenesis of T2D. The intestinal ...
• The vascular and endothelial effects of HIV, antiretroviral therapy and rooibos - functional effects and mechanism 

  Molopi, Dintle (Stellenbosch : Stellenbosch University, 2022-12)

  ENGLISH ABSTRACT: Individuals infected with human immunodeficiency virus-1 (HIV-1) are living longer but are at increased risk of cardiovascular disease (CVD). Antiretroviral therapy (ART) has been implicated in the ...
• Antimycobacterial activity of ascidian fungal symbionts 

  Tapfuma, Kudzanai Ian (Stellenbosch : Stellenbosch University, 2022-12)

  ENGLISH ABSTRACT: Tuberculosis (TB) is an infectious disease which primarily affects the lungs. Treatment of TB is complicated because the causative agent, Mycobacterium tuberculosis, is an intracellular pathogen which ...
• Investigation of Neurexin 2 as a candidate for Parkinson's Disease 

  Cuttler, Katelyn (Stellenbosch : Stellenbosch University, 2022-09)

  ENGLISH ABSTRACT: Parkinson’s disease (PD) is a neurodegenerative disorder which primarily affects movement and is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). There ...
• Linking LOXL2 to Cardiac Interstitial Fibrosis 

  Erasmus, Melisse; Samodien, Ebrahim; Lecour, Sandrine; Cour, Martin; Lorenzo, Oscar; Dludla, Phiwayinkosi; Pheiffer, Carmen; Johnson, Rabia (MDPI, 2020-08)

  Cardiovascular diseases (CVDs) are the leading causes of death worldwide. CVD pathophysiology is often characterized by increased stiffening of the heart muscle due to fibrosis, thus resulting in diminished cardiac function. ...
• Coenzyme Q10 supplementation improves adipokine levels and alleviates inflammation and lipid peroxidation in conditions of metabolic syndrome : a meta-analysis of randomized controlled trials 

  Dludla, Phiwayinkosi V.; Orlando, Patrick; Silvestri, Sonia; Marcheggiani, Fabio; Cirilli, Ilenia; Nyambuya, Tawanda M.; Mxinwa, Vuyolwethu; Mokgalaboni, Kabelo; Nkambule, Bongani B.; Johnson, Rabia; Mazibuko-Mbeje, Sithandiwe E.; Muller, Christo J. F.; Louw, Johan; Tiano, Luca (MDPI, 2020-05-04)

  Evidence from randomized controlled trials (RCTs) suggests that coenzyme Q10 (CoQ10) can regulate adipokine levels to impact inflammation and oxidative stress in conditions of metabolic syndrome. Here, prominent electronic ...
• Differential RD-1-specific IFN-γ host responses to diverse Mycobacterium tuberculosis strains in HIV-uninfected persons may be explained by genotypic variation in the ESX-1 region 

  Tomasicchio, Michele; Limberis, Jason; van der Merwe, Ruben; Jacobson, Rachael; Meldau, Richard; Theron, Grant; Nicol, Mark; Warren, Rob; Dheda, Keertan (Elsevier, 2020-04)

  Objectives: Between-person variability in T-cell-specific interferon-gamma release assay (IGRA) responses and discordance between IGRA test formats are poorly understood. Methods: We evaluated the IFN-γ responses ...
• Host urine immunological biomarkers as potential candidates for the diagnosis of tuberculosis 

  Eribo, Osagie A.; Leqheka, Monkoe S.; Malherbe, Stephanus T. (Elsevier, 2020-10-01)

  Objective: To investigate the potential of host urinary biomarkers as diagnostic candidates for tuberculosis (TB). Methods: Adults self-presenting with symptoms requiring further investigation for TB were enrolled in ...
• Toxic metal implications on agricultural soils, plants, animals, aquatic life and human health 

  Okereafor, Uchenna; Makhatha, Mamookho; Mekuto, Lukhanyo; Uche-Okereafor, Nkemdinma; Sebola, Tendani; Mavumengwana, Vuyo (MDPI, 2020-03)

  The problem of environmental pollution is a global concern as it affects the entire ecosystem. There is a cyclic revolution of pollutants from industrial waste or anthropogenic sources into the environment, farmlands, ...
• Diversity and antimicrobial activity of culturable fungal endophytes in Solanum mauritianum 

  Pelo, Sharon; Mavumengwana, Vuyo; Green, Ezekiel (MDPI, 2020-01)

  Plant endophytes are microbial sources of bioactive secondary metabolites, which mimic the natural compounds chemistry of their respective host plants in a similar manner. This study explored the isolation and identification ...
• Intimate partner violence: a risk factor for gestational diabetes 

  Pheiffer, Carmen; Dias, Stephanie; Adam, Sumaiya (MDPI, 2020-10)

  The early detection and management of gestational diabetes mellitus (GDM) is an important public health goal. GDM, which is defined as a glucose intolerance that develops during pregnancy, affects about 14% of pregnancies ...
• CHARGE syndrome : genetic aspects and dental challenges, a review and case presentation 

  Chetty, Manogari; Roberts, Tina Sharon; Elmubarak, Mona; Bezuidenhout, Heidre; Smit, Liani; Urban, Mike (BMC, 2020-05)

  Background: CHARGE syndrome (CS) is a rare genetic condition (OMIM #214800). The condition has a variable phenotypic expression. Historically, the diagnosis of CHARGE syndrome was based on the presence of specific clinical ...
• Inhibition of multidrug-resistant foodborne Staphylococcus aureus biofilms by a natural terpenoid (+)-nootkatone and related molecular mechanism 

  Farha, Arakkaveettil Kabeer; Yang, Qiong-Qiong; Kim, Gowoon; Zhang, Dan; Mavumengwana, Vuyo; Habimana, Olivier; Li, Hua-Bin; Corke, Harold; Gan, Ren-You (Elsevier, 2020-02)

  Staphylococcus aureus, a foodborne pathogen, poses serious problems to the food industries owing to biofilm formation, and over 25% of the foodborne illnesses in China have been attributed to S. aureus only. Phytochemicals ...
• Model development for predicting in vitro bio-capacity of green rooibos extract based on composition for application as screening tool in quality control 

  Viraragavan, Amsha; Hlengwa, Nokulunga; De Beer, Dalene; Riedel, Sylvia; Miller, Neil; Bowles, Sandra; Walczak, Beata; Muller, Christo; Joubert, Elizabeth (Royal Society of Chemistry, 2020-03-09)

  Mounting evidence of the ability of aspalathin to target underlying metabolic dysfunction relevant to the development or progression of obesity and type 2 diabetes created a market for green rooibos extract as a functional ...
• The beneficial role of Anchomanes difformis in STZ-induced reproductive dysfunction in male Wistar rats 

  Alabi, Toyin Dorcas; de Villiers, Charon; du Plessis, Stephan S.; Monsees, Thomas K.; Brooks, Nicole L.; Oguntibeju, Oluwafemi Omoniyi (Dove Press, 2020-11)

  Background: Progression of diabetes mellitus has increasingly led to several diabetic complications. Diabetes is one of the major factors implicated in male reproductive system damage. Recent approaches such as the use of ...

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