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Recent Submissions

  • Phase 2b controlled trial of M72/AS01E vaccine to prevent tuberculosis 

    Van der Meeren, Olivier; Hatherill, Mark; Nduba, Videlis; Wilkinson, Robert J.; Muyoyeta, Monde; Van Brakel, Elana; Ayles, Helen M.; Henostroza, German; Thienemann, Friedrich; Scriba, Thomas J.; Diacon, Andreas; Blatner, Gretta L.; Demoitie, Marie-Ange; Tameris, Michele; Malahleha, Mookho; Innes, James C.; Hellstrom, Elizabeth; Martinson, Neil; Singh, Tina; Akite, Elaine J.; Khatoon Azam, Aisha; Bollaerts, Anne; Ginsberg, Ann M.; Evans, Thomas G.; Gillard, Paul; Tait, Dereck R. (Massachusetts Medical Society, 2018-10-25)
    BACKGROUND: A vaccine to interrupt the transmission of tuberculosis is needed. METHODS: We conducted a randomized, double-blind, placebo-controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South ...
  • Spermatozoa : a historical perspective 

    Suarez, Jenniffer Puerta; Du Plessis, Stefan S.; Maya, Walter D. C. (Royan Institute, 2018)
    ENGLISH ABSTRACT: The 100,000th scientific article on the subject of spermatozoa was recently published. Numerous studies evaluated the characteristics of this important cell that led to tremendous discoveries. Since its ...
  • Revisiting the relationship between the ejaculatory abstinence period and semen characteristics 

    Ayad, Bashir M.; Van der Horst, Gerhard; Du Plessis, Stefan S. (Royan Institute, 2018)
    ENGLISH ABSTRACT: Variation in the ejaculatory abstinence period suggested by different guidance bodies have resulted in a growing concern among researchers and clinicians over what the precise period of ejaculatory ...
  • IMPUTOR : phylogenetically aware software for imputation of errors in next-generation sequencing 

    Jobin, Matthew; Schurz, Haiko; Henn, Brenna M. (Oxford University Press, 2018)
    ENGLISH ABSTRACT: We introduce IMPUTOR, software for phylogenetically aware imputation of missing haploid nonrecombining genomic data. Targeted for next-generation sequencing data, IMPUTOR uses the principle of parsimony ...
  • Unexpected genomic and phenotypic diversity of mycobacterium africanum lineage 5 affects drug resistance, protein secretion, and immunogenicity 

    Ates, Louis S.; Dippenaar, Anzaan; Sayes, Fadel; Pawlik, Alexandre; Bouchier, Christiane; Ma, Laurence; Warren, Robin M.; Sougakoff, Wladimir; Majlessi, Laleh; Van Heijs, Jeroen W. J.; Brossier, Florence; Brosch, Roland (Oxford University Press, 2018)
    ENGLISH ABSTRACT: Mycobacterium africanum consists of Lineages L5 and L6 of the Mycobacterium tuberculosis complex (MTBC) and causes human tuberculosis in specific regions of Western Africa, but is generally not transmitted ...
  • Comprehensive characterization of the attenuated double auxotroph mycobacterium tuberculosisΔleuDΔpanCD as an alternative to H37Rv 

    Mouton, Jomien M.; Heunis, Tiaan; Dippenaar, Anzaan; Gallant, James L.; Kleynhans, Leanie; Sampson, Samantha L. (Frontiers Media, 2019)
    ENGLISH ABSTRACT: Although currently available model organisms such as Mycobacterium smegmatis and Mycobacterium bovis Bacillus Calmette-Guérin (BCG) have significantly contributed to our understanding of tuberculosis (TB) ...
  • PD-1 expression on mycobacterium tuberculosis-specific CD4 T cells is associated with bacterial load in human tuberculosis 

    Day, Cheryl L.; Abrahams, Deborah A.; Bunjun, Rubina; Stone, Lynnett; De Kock, Marwou; Walzl, Gerhard; Wilkinson, Robert J.; Burgers, Wendy A.; Hanekom, Willem A. (Frontiers Media, 2018)
    ENGLISH ABSTRACT: Persistent antigen stimulation in chronic infections has been associated with antigen-specific T cell dysfunction and upregulation of inhibitory receptors, including programmed cell death protein 1 (PD-1). ...
  • Complement component C1q as serum biomarker to detect active tuberculosis 

    Lubbers, Rosalie; Sutherland, Jayne S.; Goletti, Delia; De Paus, Roelof A.; Van Moorsel, Coline H. M.; Veltkamp, Marcel; Vestjens, Stefan M. T.; Bos, Willem J. W.; Petrone, Linda; Del Nonno, Franca; Bajema, Ingeborg M.; Dijkman, Karin; Verreck, Frank A. W.; Walzl, Gerhard; Gelderman, Kyra A.; Groeneveld, Geert H.; Geluk, Annemieke; Ottenhoff, Tom H. M.; Joosten, Simone A.; Trouw, Leendert A. (Frontiers Media, 2018)
    Background: Tuberculosis (TB) remains a major threat to global health. Currently, diagnosis of active TB is hampered by the lack of specific biomarkers that discriminate active TB disease from other (lung) diseases or ...
  • Neutrophils : innate effectors of TB resistance? 

    Kroon, Elouise E.; Coussens, Anna K.; Kinnear, Craig; Orlova, Marianna; Moller, Marlo; Seeger, Allison; Wilkinson, Robert J.; Hoal, Eileen G.; Schurr, Erwin (Frontiers Media, 2018)
    ENGLISH ABSTRACT: Certain individuals are able to resist Mycobacterium tuberculosis infection despite persistent and intense exposure. These persons do not exhibit adaptive immune priming as measured by tuberculin skin ...
  • A serum circulating miRNA signature for short-term risk of progression to active tuberculosis among household contacts 

    Duffy, Fergal J.; Thompson, Ethan; Downing, Katrina; Suliman, Sara; Mayanja-Kizza, Harriet; Boom, W. Henry; Thiel, Bonnie; Weiner III, January; Kaufmann, Stefan H. E.; Dover, Drew; Tabb, David L.; Dockrell, Hazel M.; Ottenhoff, Tom H. M.; Tromp, Gerard; Scriba, Thomas J.; Zak, Daniel E.; Walzl, Gerhard; GC6-74 Consortium (Frontiers Media, 2018)
    ENGLISH ABSTRACT: Biomarkers that predict who among recently Mycobacterium tuberculosis (MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host ...
  • Monocytic myeloid-derived suppressor cells in chronic infections 

    Dorhoi, Anca; Du Plessis, Nelita (Frontiers Media, 2018)
    ENGLISH ABSTRACT: Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes, macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases. The inflammatory environment ...
  • IL-22 : an underestimated player in natural resistance to tuberculosis? 

    Ronacher, Katharina; Sinha, Roma; Cestari, Michelle (Frontiers Media, 2018)
    ENGLISH ABSTRACT: Approximately 10% of individuals latently infected with Mycobacterium tuberculosis (Mtb) develop active tuberculosis (TB) during their lifetime. Although it is well recognized that T-helper 1 immune ...
  • New insights on water buffalo genomic diversity and post-domestication migration routes from medium density SNP chip data 

    Colli, Licia; Milanesi, Marco; Vajana, Elia; Iamartino, Daniela; Bomba, Lorenzo; Puglisi, Francesco; Del Corvo, Marcello; Nicolazzi, Ezequiel L.; Ahmed, Sahar S. E.; Herrera, Jesus R. V.; Cruz, Libertado; Zhang, Shujun; Liang, Aixin; Hua, Guohua; Yang, Liguo; Hao, Xingjie; Zuo, Fuyuan; Lai, Song-Jia; Wang, Shuilian; Liu, Ruyu; Gong, Yundeng; Mokhber, Mahdi; Mao, Yongjiang; Guan, Feng; Vlaic, Augustin; Vlaic, Bogdan; Ramunno, Luigi; Cosenza, Gianfranco; Ahmad, Ali; Soysal, Ihsan; Unal, Emel O.; Ketudat-Cairns, Mariena; Garcia, Jose F.; Utsunomiya, Yuri T.; Baruselli, Pietro S.; Amaral, Maria E. J.; Parnpai, Rangsun; Drummond, Marcela G.; Galbusera, Peter; Burton, James; Hoal, Eileen; Yusnizar, Yulnawati; Sumantri, Cece; Moioli, Bianca; Valentini, Alessio; Stella, Alessandra; Williams, John L.; Ajmone-Marsan, Paolo (Frontiers Media, 2018)
    ENGLISH ABSTRACT: The domestic water buffalo is native to the Asian continent but through historical migrations and recent importations, nowadays has a worldwide distribution. The two types of water buffalo, i.e., river ...
  • Blood-based DNA methylation biomarkers for type 2 diabetes : potential for clinical applications 

    Willmer, Tarryn; Johnson, Rabia; Louw, Johan; Pheiffer, Carmen (Frontiers Media, 2018)
    ENGLISH ABSTRACT: Type 2 diabetes (T2D) is a leading cause of death and disability worldwide. It is a chronic metabolic disorder that develops due to an interplay of genetic, lifestyle, and environmental factors. The ...
  • Patients with concurrent tuberculosis and diabetes have a pro-atherogenic plasma lipid profile 

    Vrieling, Frank; Ronacher, Katharina; Kleynhans, Leanie; Van Den Akker, Erik; Walzl, Gerhard; Ottenhoff, Tom H. M.; Joosten, Simone A. (Elsevier, 2018)
    Background: Type 2 diabetes mellitus (DM) is a major risk factor for development of tuberculosis (TB), however the underlyingmolecular foundations are unclear. Since lipids play a central role in the development of both ...
  • Diabetes mellitus and male infertility 

    Omolaoye, Temidayo; Du Plessis, Stefan S. (Medknow, 2018)
    ENGLISH ABSTRACT: Infertility is prevalent in about 10%-25% of couples in their reproductive age, analogous to 60-80 million infertile couples globally. Of these infertility cases, 10%-30% are exclusively attributed to ...
  • Application of cerebrospinal fluid host protein biosignatures in the diagnosis of tuberculous meningitis in children from a high burden setting 

    Manyelo, Charles M.; Solomons, Regan S.; Snyders, Candice I.; Manngo, Portia M.; Mutavhatsindi, Hygon; Kriel, Belinda; Stanley, Kim; Walzl, Gerhard; Chegou, Novel N. (Hindawi, 2019-04)
    Background. The diagnosis of tuberculous meningitis (TBM) especially in children is challenging. New tests are urgently needed for the diagnosis of the disease, especially in resource-limited settings. Methods. We collected ...
  • Performance and immune characteristics of bronchoalveolar lavage by research bronchoscopy in pulmonary tuberculosis and other lung diseases in the Western Cape, South Africa 

    Young, Carly; Ahlers, Petri; Hiemstra, Andriette M.; Loxton, Andre G.; Gutschmidt, Andrea; Malherbe, Stephanus T.; Walzl, Gerhard; Du Plessis, Nelita (BMC (part of Springer Nature), 2019-06-01)
    Background: Tuberculosis (TB) remains a debilitating, deadly disease that warrants innovative research tools to fully understand the pathogenesis and host immune responses, particularly at the site of infection and disease. ...
  • HIV-1 subtype C envelope function becomes less sensitive to N-glycosylation deletion during disease progression 

    Lumngwena, Evelyn N.; Shuping, Liliwe; Bernitz, Netanya; Woodman, Zenda (BMC (part of Springer Nature), 2019-06-17)
    Objective: As part of a larger study to understand how Envelope N-glycosylation influences HIV-1 pathogenesis, we selected a participant infected with a single Subtype C variant and determined whether deletion of specific ...
  • Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation 

    Blignaut, Marguerite; Loos, Ben; Botchway, Stanley W.; Parker, Anthony W.; Huisamen, Barbara (Springer Nature, 2019)
    The absence of Ataxia-Telangiectasia mutated protein kinase (ATM) is associated with neurological, metabolic and cardiovascular defects. The protein has been associated with mitochondria and its absence results in mitochondrial ...

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