Effect of tramadol on depth of anaesthesia

Date
1996
Authors
Coetzee J.F.
Maritz J.S.
Du Toit J.C.
Journal Title
Journal ISSN
Volume Title
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Abstract
We have studied 51 patients who were anaesthetized with propofol and suxamethonium followed by 0.7% isoflurane and 66% nitrous oxide in oxygen to see if tramadol caused lightening of anaesthesia. A two-channel EEG was recorded and music was played via headphones. Two groups received tramadol 200 and 100 mg i.v. and the third group received saline. Tramadol caused significant, dose-dependent activation of the EEG, evidenced by increased frequencies and decreased amplitudes, but these changes were small and probably unimportant. Derived EEG variables did not approach values known to be associated with near-awakening during isoflurane anaesthesia. No patient moved on skin incision and there were no incidences of free recall.
Description
Keywords
isoflurane, nitrous oxide, oxygen, propofol, sodium chloride, suxamethonium, tramadol, adult, aged, anesthesia level, arousal, article, clinical trial, controlled clinical trial, controlled study, dose response, drug effect, electroencephalogram, human, intravenous drug administration, major clinical study, music, priority journal, randomized controlled trial, recall, skin incision, Adolescent, Adult, Aged, Analgesics, Opioid, Anesthesia, Inhalation, Anesthetics, Inhalation, Dose-Response Relationship, Drug, Drug Interactions, Electroencephalography, Humans, Isoflurane, Mental Recall, Middle Aged, Nitrous Oxide, Propofol, Succinylcholine, Tramadol
Citation
British Journal of Anaesthesia
76
3