Now showing items 1-10 of 78
Elucidation of the substrates of mycosin 3, an essential protease of Mycobacterium tuberculosis
(Stellenbosch : University of Stellenbosch, 2011-03)
ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects one third of the world’s population and kills 1.7 million people per year. The increasing prevalence of multi- and extensively ...
An investigation into the role of collectins in tuberculosis infection
(Stellenbosch : Stellenbosch University, 2005-03)
ENGLISH ABSTRACT: Please see fulltext for abstract.
Investigation into genotypic diagnostics for mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2010-12)
ENGLISH ABSTRACT: Diagnostic delay is regarded as a major contributor to the continuous rise in tuberculosis (TB) cases and the emergence and transmission of multidrug-resistant tuberculosis (MDR-TB) and extensively drug ...
The investigation of peripheral blood cellular immune responses during infection with Mycobacterium Tuberculosis
(Stellenbosch : University of Stellenbosch, 2007-03)
Despite the ongoing global tuberculosis (TB) problem and extensive research into protective immunity against this intracellular pathogen, mechanisms of protective immunity against Mycobacterium tuberculosis (Mtb) in ...
Disease dynamics in patients with drug-resistant tuberculosis residing in a high incidence community
(Stellenbosch : Stellenbosch University, 2000-12)
ENGLISH ABSTRACT: Drug-resistant tuberculosis poses a threat to global tuberculosis control by the WHO DOTS strategy. Studies in the United States and Europe have shown (i) that drug-resistant tuberculosis is present ...
BCG vaccination in South African HIV-exposed infants : risks and benefits
(Health and Medical Publishing Group (HMPG), 2009-02)
Elucidation of the mode of action of a furanone based antituberculosis compound
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: The prevalence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis has been increasing to alarming levels globally. This has been exacerbated by tuberculosis ...
Cytokines and tuberculosis : an investigation of tuberculous lung tissue and a comparison with sarcoidosis
(University of Stellenbosch. Faculty of Health Sciences. Dept. of Biomedical Sciences., 2005-12)
The formation of granulomas at the site of antigen presentation in both tuberculosis and sarcoidosis is an essential component of host immunity for controlling inflammation. Granuloma formation is a complex process that ...
Regulators of dormancy/viability of Mycobacterium tuberculosis inside the human macrophages
(Stellenbosch : Stellenbosch University, 2012-03)
ENGLISH ABSTRACT: The investigation was aimed to improve the understanding of the binding interactions between DevS and DevR that are implicated in the regulation of the dormancy response in Mycobacterium tuberculosis. ...
Genetic investigations of pneumocystis jirovecii : detection, cotrimoxazole resistance and population structure
(Stellenbosch : University of Stellenbosch, 2005-12)
Pneumocystis jirovecii is a significant contributor to the burden of disease in immunocompromised patients. The polymerase chain reaction (PCR) is more sensitive and specific than microscopy. Cotrimoxazole prophylactic ...