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Determining ancestry proportions in complex admixture scenarios in South Africa using a novel proxy ancestry selection method
(PLoS, 2013-09)
Admixed populations can make an important contribution to the discovery of disease susceptibility genes if the parental populations exhibit substantial variation in susceptibility. Admixture mapping has been used successfully, ...
Mycobacterium bovis BCG infection severely delays Trichuris muris expulsion and co-infection suppresses immune responsiveness to both pathogens
(BioMed Central, 2014-01)
Background: The global epidemiology of parasitic helminths and mycobacterial infections display extensive geographical overlap, especially in the rural and urban communities of developing countries. We investigated whether ...
Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region
(BioMed Central, 2009-09)
Background: PPE38 (Rv2352c) is a member of the large PPE gene family of Mycobacterium tuberculosis and related mycobacteria. The function of PPE proteins is unknown but evidence suggests that many are cell-surface associated ...
Bovine tuberculosis in African buffaloes : observations regarding Mycobacterium bovis shedding into water and exposure to environmental mycobacteria
(BioMed Central, 2007-09)
Background: African buffaloes are the maintenance host for Mycobacterium bovis in the endemically infected Kruger National Park (KNP). The infection is primarily spread between buffaloes via the respiratory route, but it ...
Gene polymorphisms in African buffalo sssociated with susceptibility to Bovine tuberculosis infection
(Public Library of Science -- PLoS, 2013-05)
Bovine tuberculosis (BTB) is a chronic, highly infectious disease that affects humans, cattle and numerous species of wildlife. In developing countries such as South Africa, the existence of extensive wildlife-human-livestock ...
The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa
(BioMed Central, 2010-11)
Background. The Beijing genotype of M. tuberculosis is a virulent strain that is disseminating worldwide and has a strong association with drug resistance. In the Western Cape of South Africa, epidemiological studies have ...
A threshold value for the time delay to TB diagnosis
(Public Library of Science (PLOS), 2007-08)
Backgound. In many communities where TB occurs at high incidence, the major force driving the epidemic is transmission. It is plausible that the typical long delay from the onset of infectious disease to diagnosis and ...
Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions
(BioMed Central, 2006-11)
Background: The PE and PPE multigene families of Mycobacterium tuberculosis comprise about 10% of the coding potential of the genome. The function of the proteins encoded by these large gene families remains unknown, ...
Promoter variation in the DC-SIGN–Encoding Gene CD209 is associated with tuberculosis
(Public Library of Science (PLOS), 2006-01)
Background
Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading
causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M.
tuberculosis receptor on human ...
Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation
(BioMed Central, 2009-02)
Background: Although the gene encoding for glutamine synthetase (glnA) is essential in several organisms, multiple glnA copies have been identified in bacterial genomes such as those of the phylum Actinobacteria, notably ...