Now showing items 1-9 of 9
Risk factors for infection and disease in child contacts of multidrug-resistant tuberculosis : a cross-sectional study
(BioMed Central, 2013-08)
Background: Young children exposed to Mycobacterium tuberculosis have a high risk of disease progression following infection. This study aimed to determine risk factors for M. tuberculosis infection and disease in children ...
BCG vaccination in South African HIV-exposed infants : risks and benefits
(Health and Medical Publishing Group (HMPG), 2009-02)
Resistance to pyrazinamide and ethambutol compromises MDR/XDR-TB treatment
(Health and Medical Publishing Group (HMPG), 2009-11)
Adherence to isoniazid preventive chemotherapy: a prospective community based study
(BMJ Publishing Group, 2006-09)
Background: Current international guidelines recommend 6–9 months of isoniazid (INH) preventive chemotherapy to prevent the development of active tuberculosis in children exposed to a susceptible strain of M tuberculosis. ...
The prevalence of symptoms associated with pulmonary tuberculosis in randomly selected children from a high burden community
(BMJ Publishing Group, 2005-11)
Background: Diagnosis of childhood tuberculosis is problematic and symptom based diagnostic approaches are often promoted in high burden settings. This study aimed (i) to document the prevalence of symptoms associated ...
Unexplained HIV-1 infection in children : documenting cases and assessing for possible risk factors
(Health and Medical Publishing Group (HMPG), 2004-03)
Background. In the year 2000 we reported possible horizontal transmission of HIV-1 infection between two siblings. An investigation of three families, each with an HIV-infected child but seronegative parents, permitted ...
Rifampicin resistance in Mycobacterium tuberculosis : rapid detection and implications in chemotherapy
(Health & Medical Publishing Group, 1996-01)
Objectives. Tuberculosis treatment and susceptibility testing are cumbersome, especially in the case of multidrug-resistant (MDR) Mycobacterium tuberculosis. It is known that mutations in the rpoB gene of M. tuberculosis ...
Novel application of NIH case definitions in a paediatric tuberculosis contact investigation study
(International Union Against Tuberculosis and Lung Disease, 2015-04)
BACKGROUND: International (National Institutes of Health [NIH]) case definitions have been proposed for paediatric tuberculosis (TB) diagnostic studies. The relevance of these definitions for contact tracing studies is ...
Assessing the impact of multidrug-resistant tuberculosis in children : an exploratory qualitative study
(BioMed Central, 2014-08)
Background: While the prevalence of multidrug-resistant (MDR) tuberculosis (TB) is high among children in the Western Cape of South Africa, the psychosocial implications of treatment for children with MDR-TB remain ...