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Pooled HIV-1 Viral Load Testing Using Dried Blood Spots to Reduce the Cost of Monitoring Antiretroviral Treatment in a Resource-Limited Setting

Pannus, Pieter; Fajardo, Emmanuel; Metcalf, Carol; Coulborn, Rebecca M.; Duran, Laura T.; Bygrave, Helen; Ellman, Tom; Garone, Daniela; Murowa, Michael; Mwenda, Reuben; Reid, Tony; Preiser, Wolfgang (Lippincott Williams & Wilkins Open Access, 2013-10)

Rollout of routine HIV-1 viral load monitoring is hampered by high costs and logistical difficulties associated with sample collection and transport. New strategies are needed to overcome these constraints. Dried blood ...

Diagnostic virology : excessive expenditure or essential contribution to health care?

Preiser, Wolfgang (Stellenbosch : University of Stellenbosch, 2009)

Inaugural address delivered by Prof Wolfgang Preiser on 15 September 2009.

Pandemic flu (H1N1) 2009 and pregnancy

Andersson, Monique I.; Van Zyl, Gert; Preiser, Wolfgang; Langenegger, Eduard; Theron, Gerhard (Health and Medical Publishing Group (HMPG), 2010-04)

Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa

Ithete, Ndapewa Laudika; Stoffberg, Samantha; Corman, Victor Max; Cottontail, Veronika M.; Richards, Leigh Rosanne; Schoeman, M. Corrie; Drosten, Christian; Drexler, Jan Felix; Preiser, Wolfgang (Centers for Disease Control and Prevention (CDC), 2013-10)

We now report the identification of a South Africa bat derived CoV that has an even closer phylogenetic relationship with MERS-CoV.

Pooling strategies to reduce the cost of HIV-1 RNA load monitoring in a resource-limited setting

Preiser, Wolfgang; Potschka, Susanne; Lundershausen, Anna-Teresa; Haubrich, Richard; Smith, David; Van Zyl, Gert U. (Oxford University Press, 2011-01)

Background. Quantitative human immunodeficiency virus (HIV) RNA load testing surpasses CD4 cell count and clinical monitoring in detecting antiretroviral therapy (ART) failure; however, its cost can be prohibitive. Recently, ...

Trends in genotypic HIV-1 antiretroviral resistance between 2006 and 2012 in South African patients receiving first- and second-line antiretroviral treatment regimens

Van Zyl, Gert U.; Liu, Tommy F.; Claassen, Mathilda; Engelbrecht, Susan; De Oliveira, Tulio; Preiser, Wolfgang; Wood, Natasha T.; Travers, Simon; Shafer, Robert W. (Public Library of Science -- PLoS, 2013-06)

Objectives: South Africa’s national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. ...

HIV Drug Resistance (HIVDR) in antiretroviral therapy-naive patients in Tanzania not eligible for WHO Threshold HIVDR survey is dramatically high

Kasang, Christa; Kalluvya, Samuel; Majinge, Charles; Stich, August; Bodem, Jochen; Kongola, Gilbert; Jacobs, Graeme; Mlewa, Mathias; Mildner, Miriam; Hensel, Irina; Horn, Anne; Preiser, Wolfgang; Van Zyl, Gert; Klinker, Hartwig; Koutsilieri, Eleni; Rethwilm, Axel; Scheller, Carsten; Weissbrich, Benedikt (Public Library of Science (PLoS), 2011-08-19)

BACKGROUND: The World Health Organization (WHO) has recommended guidelines for a HIV drug resistance (HIVDR) survey for resource-limited countries. Eligibility criteria for patients include age below 25 years in order to ...

Pandemic influenza A (H1N1) 2009 : the experience of the first six months

Maritz, Jean; Maree, Leana; Preiser, Wolfgang (Walter de Gruyter, 2010-04)

After a break of 41 years, 2009 saw the first influenza pandemic of the 21st century caused by a triple-reassortant influenza A (H1N1) virus. The current estimated case fatality rate is lower than that of previous influenza ...

A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy

Newman, Howard; Breunig, Lukas; Van Zyl, Gert; Stich, August; Preiser, Wolfgang (Elsevier, 2014-08)

ENGLISH ABSTRACT: Background: The high cost of commercial HIV-1 viral load tests for monitoring of patients on antiretroviral treatment limits their use in resource-constrained settings. Commercial genotypic antiretroviral ...

Rooting the phylogenetic tree of Middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat

Corman, V. M.; Ithete, Ndapewa L.; Richards, L. R.; Schoeman, M. C.; Preiser, Wolfgang; Drosten, C.; Drexler, J. F. (American Society for Microbiology, 2014-10)

The emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes lethal respiratory infections mainly on the Arabian Peninsula. The evolutionary origins of MERS-CoV are unknown. We determined the full genome ...