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HPTN 071 (PopART) : rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment - a study protocol for a cluster randomised trial
(BioMed Central, 2014-02)
Abstract
Background
Effective interventions to reduce HIV incidence in sub-Saharan Africa are urgently needed. Mathematical modelling and the HIV Prevention Trials Network (HPTN) 052 trial ...
Missed opportunities for retention in pre-ART care in Cape Town, South Africa
(Public Library of Science -- PLoS, 2014-05)
Background: Few studies have evaluated access to and retention in pre-ART care.
Objectives: To evaluate the proportion of People Living With HIV (PLWH) in pre-ART and ART care and factors associated
with retention in ...
Prevalence of tuberculosis, HIV and respiratory symptoms in two Zambian communities: Implications for tuberculosis control in the era of HIV
(Public Library of Science (PLOS), 2009-05)
Background: The Stop TB Partnership target for tuberculosis is to have reduced the prevalence of tuberculosis by 50% comparing 2015 to 1990. This target is challenging as few prevalence surveys have been conducted, especially ...
Operational challenges in managing Isoniazid Preventive Therapy in child contacts : a high-burden setting perspective
(2011-07-08)
Abstract Background The study was conducted at a high TB-HIV burden primary health community clinic in Cape Town, South Africa. We describe the management of children under five years of age in household contact with a ...
Risk factors associated with positive quantiFERON-TB gold in-tube and tuberculin skin tests results in Zambia and South Africa
(Public Library of Science (PLOS), 2011-04)
Introduction: The utility of T-cell based interferon-gamma release assays for the diagnosis of latent tuberculosis infection remains unclear in settings with a high burden of tuberculosis. Objectives: To determine risk ...
The rate of sputum smear-positive tuberculosis after treatment default in a high-burden setting : a retrospective cohort study
(PLoS, 2012-09)
Rationale: High rates of recurrent tuberculosis after successful treatment have been reported from different high burden settings in Sub-Saharan Africa. However, little is known about the rate of smear-positive tuberculosis ...
Annual risk of tuberculous infection using different methods in communities with a high prevalence of TB and HIV in Zambia and South Africa
(Public Library of Science (PLOS), 2009-11)
Background: The annual risk of tuberculous infection (ARTI) is a key epidemiological indicator of the extent of transmission in a community. Several methods have been suggested to estimate the prevalence of tuberculous ...
High prevalence of Tuberculosis and insufficient case detection in two communities in the Western Cape, South Africa
(PLoS ONE, 2013-04)
Background: In South Africa the estimated incidence of all forms of tuberculosis (TB) for 2008 was 960/100000. It was reported that all South Africans lived in districts with Directly Observed Therapy, Short-course. However, ...
Age-disparity, sexual connectedness and HIV infection in disadvantaged communities around Cape Town, South Africa: A study protocol
(BioMed Central Ltd, 2011)
Abstract: Background Crucial connections between sexual network structure and the distribution of HIV remain inadequately understood, especially in regard to the role of concurrency and age disparity in relationships, and ...
Childhood tuberculosis in South Africa : what is the present status?
(Health and Medical Publishing Group (HMPG), 2007-10)
In a recently published article it was estimated that the
incidence of childhood tuberculosis (TB) in the Western Cape
was 407 new cases per 100 000 childhood population per
year.1 This incidence was approximately half ...