Now showing items 1-10 of 10
HPTN 071 (PopART) : rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment - a study protocol for a cluster randomised trial
(BioMed Central, 2014-02)
Abstract Background Effective interventions to reduce HIV incidence in sub-Saharan Africa are urgently needed. Mathematical modelling and the HIV Prevention Trials Network (HPTN) 052 trial ...
Prevalence of tuberculosis, HIV and respiratory symptoms in two Zambian communities: Implications for tuberculosis control in the era of HIV
(Public Library of Science (PLOS), 2009-05)
Background: The Stop TB Partnership target for tuberculosis is to have reduced the prevalence of tuberculosis by 50% comparing 2015 to 1990. This target is challenging as few prevalence surveys have been conducted, especially ...
Risk factors associated with positive quantiFERON-TB gold in-tube and tuberculin skin tests results in Zambia and South Africa
(Public Library of Science (PLOS), 2011-04)
Introduction: The utility of T-cell based interferon-gamma release assays for the diagnosis of latent tuberculosis infection remains unclear in settings with a high burden of tuberculosis. Objectives: To determine risk ...
Validation of brief screening tools for depressive and alcohol use disorders among TB and HIV patients in primary care in Zambia
(BioMed Central, 2011-05-04)
This study was conducted to evaluate the diagnostic accuracy and determine the optimum cut-off scores for clinical use of the Center for Epidemiological Studies Depression scale (CES-D) and Alcohol Use Disorders Identification ...
Annual risk of tuberculous infection using different methods in communities with a high prevalence of TB and HIV in Zambia and South Africa
(Public Library of Science (PLOS), 2009-11)
Background: The annual risk of tuberculous infection (ARTI) is a key epidemiological indicator of the extent of transmission in a community. Several methods have been suggested to estimate the prevalence of tuberculous ...
High prevalence of Tuberculosis and insufficient case detection in two communities in the Western Cape, South Africa
(PLoS ONE, 2013-04)
Background: In South Africa the estimated incidence of all forms of tuberculosis (TB) for 2008 was 960/100000. It was reported that all South Africans lived in districts with Directly Observed Therapy, Short-course. However, ...
HPTN 071 (PopART) : a cluster-randomized trial of the population impact of an HIV combination prevention intervention including universal testing and treatment : mathematical model
Background: The HPTN 052 trial confirmed that antiretroviral therapy (ART) can nearly eliminate HIV transmission from successfully treated HIV-infected individuals within couples. Here, we present the mathematical modeling ...
The association of hyperglycaemia with prevalent tuberculosis : a population-based cross-sectional study
(BioMed Central, 2016)
Background: Systematic reviews suggest that the incidence of diagnosed tuberculosis is two- to- three times higher in those with diabetes mellitus than in those without. Few studies have previously reported the ...
HIV treatment-as-prevention research : taking the right road at the crossroads
(Public Library of Science, 2015)
No abstract available
Patient diagnostic rate as indicator of tuberculosis case detection, South Africa
(Centers for Disease Control and PreventionPublisher's version, 2016)
ENGLISH SUMMARY : To address the uncertainty of the indirectly measured tuberculosis case detection rate, we used survey data stratified by HIV status to calculate the patient diagnostic rate, a directly measurable indicator, ...