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Investigating the Human-M. tuberculosis interactome to identify the host targets of ESAT-6 and other mycobacterial antigens
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: The causative agent of human tuberculosis, Mycobacterium tuberculosis, is an intracellular
pathogen that secretes virulence factors, namely ESAT-6 and CFP-10, as substrates of the
ESX-1 secretion system. ...
The contribution of the placenta to the diagnosis of congenital tuberculosis
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: The aim of this pilot project was to determine whether mothers with laboratory confirmed or clinically
suspected tuberculosis (TB)
had evidence of TB in the placenta. A secondary objective was to ...
Investigation into genotypic diagnostics for mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2010-12)
ENGLISH ABSTRACT: Diagnostic delay is regarded as a major contributor to the continuous rise in tuberculosis (TB)
cases and the emergence and transmission of multidrug-resistant tuberculosis (MDR-TB) and
extensively drug ...
Identification of mechanisms regulating the intra cellular concentration of rifampicin in Mycobacterium Tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Rifampicin resistance in clinical isolates of Mycobacterium tuberculosis develops through selection of bacterial variants harbouring mutations in the rpoB gene. These mutations infer a fitness-cost in the ...
Regulation of efflux in rifampicin resistant mutants of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Multidrug resistant tuberculosis (MDR-TB), defined as having resistance to at least the first-line drugs, isoniazid and rifampicin (RIF), is a global health problem. Mutations in the rpoB gene, encoding ...
Understanding the evolution and function of the mycobacterial Type VII ESX secretion systems (T7SSs) and their substrates
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative agent of tuberculosis disease, contains five copies of the ESAT-6
gene cluster, each encoding a dedicated ESX protein secretion system which has been defined as ...
The Mycobacterium tuberculosis ESX-3 secretion system interactome
(Stellenbosch : University of Stellenbsoch, 2010-03)
ENGLISH ABSTRACT: Mycobacterium tuberculosis is the causative agent of tuberculosis, a disease which causes
approximately 2 million deaths each year. Despite extensive research on tuberculosis and M.
tuberculosis, little ...
The development of a novel fluorescentmarker phage technology system for the early diagnosis of tuberculosis disease
(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), is a major cause for mortality and
morbidity world-wide with a death toll only second to HIV among infectious diseases. Drug ...
Mapping of the distribution of Mycobacterium bovis strains involved in bovine tuberculosis in Mozambique
(Stellenbosch : Stellenbosch University, 2015-12)
ENGLISH ABSTRACT: Bovine tuberculosis (BTB), caused by bacteria of the Mycobacterium tuberculosis complex is
reported to cause economic and public health negative impact in countries where it is prevalent.
The control ...
Deciphering the impact of rpoB mutations on the gene expression profile of Mycobacterium tuberculosis
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Mycobacterium tuberculosis is the etiological agent for tuberculosis, an infectious disease which is one of the leading causes of morbidity and mortality in developing countries. The emergence of drug ...