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The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Introduction:
The cardioprotective actions of the hormone melatonin against myocardial ischaemiareperfusion
injury (IRI) are well-established. It has recently been shown to prevent the harmful
effects ...
Investigating the cholesterol-independent (pleiotropic) effects of selected hypolipidaemic agents in functional and dysfunctional endothelial cells
(Stellenbosch : Stellenbosch University, 2015-03)
ENGLISH ABSTRACT: Vascular endothelium forms the first line of defence against harmful stimuli in the circulation.
Endothelial dysfunction is a valuable predictor of cardiovascular disease and therapies aimed at
improving ...
Measurement of free radicals and their effects on human spermatozoa
(Stellenbosch : University of Stellenbosch, 2006-03)
In this study, we presented data on the role of free radicals in human spermatozoa, particularly in the context of centrifugation and the potential development of defective sperm function. In order to achieve this, methods ...
Nitric oxide and the endothelium : characterisation of in vitro nitric oxide detection techniques and an ex vivo method of measuring endothelial function
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Introduction: Nitric oxide (NO) is an important chemical messenger in the cardiovascular
system. Despite considerable progress in this field, there remains an on-going need for
affordable and user-friendly ...
Exposure of cardiac microvascular endothelial cells to harmful stimuli : a study of the cellular responses and mechanisms
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Exposure to harmful stimuli can render vascular endothelial cells dysfunctional, characterised by
reduced nitric oxide (NO) bioavailibility. Endothelial dysfunction (ED) is a reversible precursor ...
An investigation of the importance of the ATM protein in the endothelium and its role in the signalling pathways of NO production
(Stellenbosch : Stellenbosch University, 2015-04)
ENGLISH ABSTRACT: Ataxia telangiectasia (AT) is a well-characterized neurodegenerative disease resulting from a genetic defect in the Atm gene causing an absence or very low expression of the ATM protein. As AT patients ...
The effect of Cyclopia maculata extract on β-cell function, protection against oxidative stress and cell survival
(Stellenbosch : Stellenbosch University, 2014-12)
ENGLISH ABSTRACT: Insights into the role of oxidative stress and pancreatic β-cell dysfunction in the pathogenesis of type 2 diabetes (T2D) reveals an opportunity for the development of novel therapeutics that directly ...
Endothelial dysfunction in cardiac microvascular endothelial cells : an investigation into cellular mechanisms and putative role of oleanolic acid in reversing endothelial dysfunction
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: Introduction: The discovery of the endothelium as a regulator of vascular tone, and the subsequent discovery of nitric oxide (NO) as the major endothelium-derived relaxing factor (EDRF), has opened up ...
A diffusion tensor imaging study in HIV patients with and without apathy
(Stellenbosch : University of Stellenbosch, 2010-12)
ENGLISH ABSTRACT: HIV/AIDS is a global epidemic that accounts for a large percentage of the mortality in South
Africa every year. Since the implementation of anti-retroviral treatment, HIV positive
individuals have been ...
The responses of endothelium to insult : does endothelial heterogeneity play a role in in vitro cell models
(Stellenbosch : Stellenbosch University, 2015-12)
ENGLISH ABSTRACT: Endothelial injury and dysfunction precede the development of cardiovascular diseases. The endothelium may be regarded as the first line of defence against inflammation / obesity-induced vascular injury, ...