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The effect of 5'-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and 5'-aminoimidazole-4-carboxamide-ribonucleoside-phosphate (ZMP) on myocardial glucose uptake
(Stellenbosch : Stellenbosch University, 2005-03)
ENGLISH ABSTRACT: Introduction: Exercise increases skeletal muscle glucose uptake via AMP-activated
protein kinase (AMPK) activation and GLUT4 translocation from cytosol to cell
membrane. It also promotes glucose ...
The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Introduction:
The cardioprotective actions of the hormone melatonin against myocardial ischaemiareperfusion
injury (IRI) are well-established. It has recently been shown to prevent the harmful
effects ...
Investigation into the intracellular mechanisms whereby long-chain fatty acids protect the heart in ischaemia/reperfusion
(Stellenbosch : Stellenbosch University, 2005-03)
ENGLISH ABSTRACT: Although there is evidence for a protective role of long-chain polyunsaturated
fatty acids (PUFAs) in cardiovascular disease, their mechanism of action as
well as their participation in intracellular ...
The role of Protein Phosphatase 2A (PP2A) in myocardial ischaemia/reperfusion injury
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Ischaemic heart disease is a major contributor to global morbidity and mortality rates. Manoeuvres
such as ischaemic preconditioning confer cardioprotection against ischaemia/reperfusion (I/R)
injury ...
Hypoxia and the heart : the role of nitric oxide in cardiac myocytes and endothelial cells
(Stellenbosch : University of Stellenbosch, 2007-03)
Nitric oxide (NO) is a major signaling molecule in the heart with various biological
effects. The putative role of NO as a cardioprotective agent against ischaemiareperfusion
injury and in ischaemic preconditioning (IP) ...
The role of p38 MAPK activation in preconditioning mediated protection against ischaemia/reperfusion injury
(Stellenbosch : Stellenbosch University, 2002-12)
ENGLISH ABSTRACT: The ultimate consequence of the interruption of blood flow to the myocardium is
necrosis. In view of the prevalence of coronary artery disease in the general
population, and the deleterious effects of ...
The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance
(Stellenbosch : Stellenbosch University, 2012-03)
ENGLISH ABSTRACT: Introduction: The worldwide escalation in the incidence of obesity and its strong association
with insulin resistance, type 2 diabetes and the cardiovascular complications that accompany
these disease ...
The role of protein phosphatases in myocardial ischaemia and reperfusion
(Stellenbosch : Stellenbosch University, 2008-03)
ENGLISH ABSTRACT: Protein kinases and phosphatases play important roles in the phosphorylation state of intracellular proteins under both physiologic and pathophysiologic conditions. Compared to the large number of studies ...
Effect of melatonin on myocardial susceptibility to ischaemia and reperfusion damage in a rat model of high-fat diet-induced obesity
(Stellenbosch : Stellenbosch University, 2015-12)
ENGLISH ABSTRACT: Obesity has reached epidemic proportions worldwide and is currently a serious health problem.
It is associated with metabolic abnormalities, oxidative stress, hypertension, insulin resistance
and an ...
The role of the beta3-adrenergic receptor (β3-AR) in cardioprotection
(Stellenbosch : Stellenbosch University, 2015-12)
ENGLISH ABSTRACT: It is well-established that transient activation of the β-adrenergic signalling pathway with ligands such as isoproterenol, formoterol and dobutamine, elicits cardioprotection against subsequent long ...