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The effect of 5'-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and 5'-aminoimidazole-4-carboxamide-ribonucleoside-phosphate (ZMP) on myocardial glucose uptake
(Stellenbosch : Stellenbosch University, 2005-03)
ENGLISH ABSTRACT: Introduction: Exercise increases skeletal muscle glucose uptake via AMP-activated
protein kinase (AMPK) activation and GLUT4 translocation from cytosol to cell
membrane. It also promotes glucose ...
The role of melatonin in cardioprotection : an investigation into the mechanisms involved in glucose homeostasis, microvascular endothelial function and mitochondrial function in normal and insulin resistant states
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Introduction:
The cardioprotective actions of the hormone melatonin against myocardial ischaemiareperfusion
injury (IRI) are well-established. It has recently been shown to prevent the harmful
effects ...
Investigating the cholesterol-independent (pleiotropic) effects of selected hypolipidaemic agents in functional and dysfunctional endothelial cells
(Stellenbosch : Stellenbosch University, 2015-03)
ENGLISH ABSTRACT: Vascular endothelium forms the first line of defence against harmful stimuli in the circulation.
Endothelial dysfunction is a valuable predictor of cardiovascular disease and therapies aimed at
improving ...
The impact of activation of the renin-angiotensin system in the development of insulin resistance in experimental models of obesity
(Stellenbosch : University of Stellenbosch, 2009-03)
Insulin stimulates the production of nitric oxide (NO) in endothelial cells and cardiac
myocytes by a signalling pathway that involves the insulin receptor substrate (IRS)-1,
phosphatidylinositol-3-kinase and protein ...
The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance
(Stellenbosch : Stellenbosch University, 2012-03)
ENGLISH ABSTRACT: Introduction: The worldwide escalation in the incidence of obesity and its strong association
with insulin resistance, type 2 diabetes and the cardiovascular complications that accompany
these disease ...
Exposure of cardiac microvascular endothelial cells to harmful stimuli : a study of the cellular responses and mechanisms
(Stellenbosch : Stellenbosch University, 2014-04)
ENGLISH ABSTRACT: Exposure to harmful stimuli can render vascular endothelial cells dysfunctional, characterised by
reduced nitric oxide (NO) bioavailibility. Endothelial dysfunction (ED) is a reversible precursor ...
A critical analysis of mitochondrial functioning and associated proteins in obesity-related cardiomyopathy
(Stellenbosch : Stellenbosch University, 2013-03)
ENGLISH ABSTRACT: INTRODUCTION: The mechanism behind obesity-related cardiomyopathies is at present not completely known, however, cardiac insulin resistance has been implicated as one of the main arbitrators of obesity-related ...
An investigation of the importance of the ATM protein in the endothelium and its role in the signalling pathways of NO production
(Stellenbosch : Stellenbosch University, 2015-04)
ENGLISH ABSTRACT: Ataxia telangiectasia (AT) is a well-characterized neurodegenerative disease resulting from a genetic defect in the Atm gene causing an absence or very low expression of the ATM protein. As AT patients ...
A study of the early changes in hearts from diet-induced obese rats that may lead to cardiac dysfunction
(Stellenbosch : University of StellenboschStellenbosch : University of Stellenbosch, 2011-03)
ENGLISH ABSTRACT: INTRODUCTION: Obesity and its associated complications such as diabetes and cardiovascular disease are escalating worldwide. Cardiovascular mortality and the occurrence of heart failure following a ...
Effect of melatonin on myocardial susceptibility to ischaemia and reperfusion damage in a rat model of high-fat diet-induced obesity
(Stellenbosch : Stellenbosch University, 2015-12)
ENGLISH ABSTRACT: Obesity has reached epidemic proportions worldwide and is currently a serious health problem.
It is associated with metabolic abnormalities, oxidative stress, hypertension, insulin resistance
and an ...