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The apoptotic potential of different HIV-1 subtype C Tat mutations in cell culture
(Stellenbosch : Stellenbosch University, 2013-03)
The efficiency in which HIV-1 can infect, spread and evade the attack of therapeutic
agents can be attributed to a high mutation rate and frequent recombination events.
These factors have collectively contributed to the ...
Investigation of the molecular epidemiology of HIV-1 in Khayelitsha, Cape Town, using serotyping and genotyping techniques
(Stellenbosch : University of Stellenbosch, 2005-12)
There are currently an estimated 5.3 million people infected with human
immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) in
South Africa. HIV-1 group M Subtype C is currently responsible for the ...
Phylogenetic analysis of HIV-1 in Mpumalanga
(Stellenbosch : Stellenbosch University, 2013-03)
The diversity of HIV-1 sequences derived from patients in Bushbuckridge, Mpumalanga, was investigated. The gag p24, pol p10 and p66/p51, pol p31 and env gp41 gene fragments from 51 patients were amplified and sequenced. ...
Molecular characterization of non-subtype C and recombinant HIV-1 viruses from Cape Town, South Africa
(Stellenbosch : University of Stellenbosch, 2009-03)
ENGLISH ABSTRACT: HIV-1 was first diagnosed within South Africa in 1982. In the 1980’s homosexual transmission dominated the HIV-1 epidemic within the country. In the late 1980’s the second HIV-1 epidemic was recognized ...
Development of selective real-time PCR (SPCR) asays for the detection of K103N resistance mutation in minor HIV-1 populations
(Stellenbosch : Stellenbosch University, 2011-12)
ENGLISH ABSTRACT: Background: The conventional sequence analysis is the most common method used for the detection of drug-resistant mutants. Due to its sensitivity limitations, it is unable to detect these mutants when ...
Origin and phylodynamics of HIV-1 subtype C in South Africa
(Stellenbosch : Stellenbosch University, 2013-12)
ENGLISH ABSTRACT: The HIV epidemic in the past couple of decades has spread at an alarming rate throughout Southern Africa. Today the region accounts for roughly one third of all HIV infections, while prevalence rates in ...
In-house genotypic antiretroviral resistance test : optimisation and validation for use in research and diagnostics
(Stellenbosch : University of Stellenbosch, 2011-03)
It is estimated that 32.8 million people are living with Human Immunodeficiency
Virus (HIV) globally with the number of people receiving antiretroviral therapy in
low- and middle- income counties increasing to more than ...
Mutagenesis and functional studies of the HIV-1 vpr gene and Vpr protein obtained from South African virus strains
(Stellenbosch : University of Stellenbosch, 2011-03)
ENGLISH ABSTRACT: Background: Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is
an accessory protein that interacts with a number of host cellular and other viral
proteins. Vpr exerts several functions ...
Next generation sequencing demonstrates minor variant HIV drug resistance mutations
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: Introduction: The South African public sector antiretroviral therapy (ART) roll-out has been associated with emergence of HIV drug resistance (HIVDR) in therapy-naïve and treated patients. These drug-resistant ...
Investigating the fitness benefit of reverse transcriptase (RT) mutation A62V when co-occurring with M184V and K65R in HIV-1 subtype C
(Stellenbosch : Stellenbosch University, 2016-03)
ENGLISH ABSTRACT: Background and Aims
Tenofovir disoproxil fumarate (TDF) and lamivudine (3TC) or emtricitabine (FTC) combined with efavirenz is the predominant first-line antiretroviral regimen in the Southern African ...