Depressive symptoms at baseline predict fewer negative symptoms at follow-up in patients with first-episode schizophrenia
Date
2002
Authors
Oosthuizen P.
Emsley R.A.
Roberts M.C.
Turner J.
Keyter L.
Keyter N.
Torreman M.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
There is uncertainty regarding the prognostic value of depressive symptoms in schizophrenia, having previously been associated with both favourable and poor outcome. This study investigated the relationship between baseline depressive symptoms and treatment outcome at 6, 12 and 24 weeks in 80 subjects with first-episode schizophrenia or schizophreniform disorder in terms of PANSS total and subscale score changes. No significant association was found between baseline PANSS depression factor scores and PANSS total and subscore changes. However, a significant inverse correlation between baseline depression scores and negative scores at 6, 12 and 24 weeks was found (p=0.044, 0.023 and 0.012, respectively). Multiple regression analysis indicated that this finding could not be explained on the basis of age, gender or duration of untreated psychosis. These findings support previous work suggesting that high baseline depressive scores predict favourable outcome. © 2002 Elsevier Science B.V. All rights reserved.
Description
Keywords
antidepressant agent, haloperidol, lorazepam, orphenadrine, risperidone, trihexyphenidyl, adult, age, aged, article, clinical trial, controlled clinical trial, controlled study, correlation analysis, depression, disease association, extrapyramidal symptom, female, follow up, gender, human, major clinical study, male, multiple regression, negative syndrome, priority journal, prognosis, psychosis, schizophrenia, schizophreniform disorder, side effect, symptomatology, treatment outcome, Adolescent, Adult, Aged, Antidepressive Agents, Antipsychotic Agents, Depression, Double-Blind Method, Drug Administration Schedule, Female, Follow-Up Studies, Haloperidol, Humans, Male, Middle Aged, Predictive Value of Tests, Risperidone, Schizophrenia, Schizophrenic Psychology, Severity of Illness Index
Citation
Schizophrenia Research
58
03-Feb
58
03-Feb