Efficacy and safety of saccharomyces boulardii in the treatment of acute gastroenteritis in the paediatric population : a systematic review
Date
2018-04-12
Journal Title
Journal ISSN
Volume Title
Publisher
MedPharm Publications
Abstract
Context: Gastroenteritis (GE) remains the second major cause of death in the most vulnerable of the world’s populations. Potential treatments include the use of probiotics, with the yeast Saccharomyces boulardii being one such option.
Objectives: The primary objective was to assess the efficacy and safety of Saccharomyces boulardii in the treatment of acute GE in the paediatric population.
Method: Major electronic databases were searched from April 2014 to January 2015. Additional literature was obtained through hand-searching and reviewing of reference lists of articles and other systematic reviews. Randomised controlled trials (RCTs) in a hospital setting, involving participants < 16 years were used as the data source. Two reviewers independently screened studies for eligibility, assessed study quality and performed data extraction. Review Manager 5 was used to analyse data and a random-effects model of meta-analysis was applied owing to heterogeneity.
Results: Ten of 190 articles were selected for final inclusion. A meta-analysis of five of the included studies showed that Saccharomyces boulardii compared with the control significantly shortened the duration of diarrhoea (in days) (MD –0.57, 95% CI –0.83 to –0.30, p < 0.0001), but there was no difference between groups regarding time to achieving formed stools. No adverse effects were reported. The GRADE tool assessed overall methodological quality as moderate.
Conclusion: Saccharomyces boulardii showed a potential benefit in treating acute GE in the paediatric patient. A dose of 250 mg 1–2 times per day for up to 5 days showed some benefit and appears safe. Larger, rigorous RCTs are needed to investigate the efficacy and safety of Saccharomyces boulardii in order to offer specific treatment guidelines.
Description
CITATION: Padayachee, M. 2019. Efficacy and safety of Saccharomyces boulardii in the treatment of acute gastroenteritis in the paediatric population: a systematic review, South African Journal of Clinical Nutrition, 32(3):58-69. doi:10.1080/16070658.2018.1449378
The original publication is available at https://www.tandfonline.com/toc/ojcn20/current
The original publication is available at https://www.tandfonline.com/toc/ojcn20/current
Keywords
Gastroenteritis in children -- Treatment, Saccharomyces, Probiotics, Microorganisms -- Development, Clinical trials, Systematic reviews (Medical research)
Citation
Padayachee, M. 2019. Efficacy and safety of Saccharomyces boulardii in the treatment of acute gastroenteritis in the paediatric population: a systematic review. South African Journal of Clinical Nutrition, 32(3):58-69. doi:10.1080/16070658.2018.1449378